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Protein

HTH-type transcriptional repressor RspR

Gene

rspR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of the rspAB operon. Acts by binding directly to the upstream region of rspA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi38 – 57H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G6814-MONOMER.
ECOL316407:JW1533-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor RspR
Gene namesi
Name:rspRImported
Synonyms:ydfH
Ordered Locus Names:b1540, JW1533
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13820. rspR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506721 – 228HTH-type transcriptional repressor RspRAdd BLAST228

Proteomic databases

PaxDbiP0ACM2.
PRIDEiP0ACM2.

Interactioni

Protein-protein interaction databases

BioGridi4261737. 14 interactors.
IntActiP0ACM2. 2 interactors.
STRINGi511145.b1540.

Structurei

3D structure databases

ProteinModelPortaliP0ACM2.
SMRiP0ACM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 78HTH gntR-typePROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Contains 1 HTH gntR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107XBN. Bacteria.
COG1802. LUCA.
HOGENOMiHOG000273994.
InParanoidiP0ACM2.
OMAiVECTIPP.
PhylomeDBiP0ACM2.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVETQLNPT QPVNQQIYRI LRRDIVHCLI APGTPLSEKE VSVRFNVSRQ
60 70 80 90 100
PVREAFIKLA ENGLIQIRPQ RGSYVNKISM AQVRNGSFIR QAIECAVARR
110 120 130 140 150
AASMITESQC YQLEQNLHQQ RIAIERKQLD DFFELDDNFH QLLTQIADCQ
160 170 180 190 200
LAWDTIENLK ATVDRVRYMS FDHVSPPEML LRQHLDIFSA LQKRDGDAVE
210 220
RAMTQHLQEI SESVRQIRQE NSDWFSEE
Length:228
Mass (Da):26,565
Last modified:November 22, 2005 - v1
Checksum:i8CFF8EB3BCF9AF84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74613.1.
AP009048 Genomic DNA. Translation: BAA15242.1.
PIRiG64908.
RefSeqiNP_416058.1. NC_000913.3.
WP_000215549.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74613; AAC74613; b1540.
BAA15242; BAA15242; BAA15242.
GeneIDi946087.
KEGGiecj:JW1533.
eco:b1540.
PATRICi32118380. VBIEscCol129921_1610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74613.1.
AP009048 Genomic DNA. Translation: BAA15242.1.
PIRiG64908.
RefSeqiNP_416058.1. NC_000913.3.
WP_000215549.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACM2.
SMRiP0ACM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261737. 14 interactors.
IntActiP0ACM2. 2 interactors.
STRINGi511145.b1540.

Proteomic databases

PaxDbiP0ACM2.
PRIDEiP0ACM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74613; AAC74613; b1540.
BAA15242; BAA15242; BAA15242.
GeneIDi946087.
KEGGiecj:JW1533.
eco:b1540.
PATRICi32118380. VBIEscCol129921_1610.

Organism-specific databases

EchoBASEiEB3581.
EcoGeneiEG13820. rspR.

Phylogenomic databases

eggNOGiENOG4107XBN. Bacteria.
COG1802. LUCA.
HOGENOMiHOG000273994.
InParanoidiP0ACM2.
OMAiVECTIPP.
PhylomeDBiP0ACM2.

Enzyme and pathway databases

BioCyciEcoCyc:G6814-MONOMER.
ECOL316407:JW1533-MONOMER.

Miscellaneous databases

PROiP0ACM2.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSPR_ECOLI
AccessioniPrimary (citable) accession number: P0ACM2
Secondary accession number(s): P77577, Q83L25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.