P0ACM0 (PDHR_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyruvate dehydrogenase complex repressor

Gene names

Name:	pdhR
Ordered Locus Names:	c0140

Organism

Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) [Complete proteome] [HAMAP]

Taxonomic identifier

199310 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd By similarity.
Sequence similarities	Contains 1 HTH gntR-type DNA-binding domain.
Sequence caution	The sequence AAN78636.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Pyruvate dehydrogenase complex repressor		PRO_0000050664
Regions
	Domain	9 – 77	69	HTH gntR-type
	DNA binding	37 – 56	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0ACM0 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: AF20245D3D3F751D	FASTA	254	29,425
	10 20 30 40 50 60 MAYSKIRQPK LSDVIEQQLE FLILEGTLRP GEKLPPEREL AKQFDVSRPS LREAIQRLEA 70 80 90 100 110 120 KGLLLRRQGG GTFVQSSLWQ SFSDPLVELL SDHPESQYDL LETRHALEGI AAYYAALRST 130 140 150 160 170 180 DEDKERIREL HHAIELAQQS GDLDAESNAV LQYQIAVTEA AHNVVLLHLL RCMEPMLAQN 190 200 210 220 230 240 VRQNFELLYS RREMLPLVSS HRTRIFEAIM AGKPEEAREA SHRHLAFIEE ILLDRSREES 250 RRERSLRRLE QRKN

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014075 Genomic DNA. Translation: AAN78636.1. Different initiation.
RefSeq	NP_752092.2. NC_004431.1.
3D structure databases
ProteinModelPortal	P0ACM0.
SMR	P0ACM0. Positions 15-235.
ModBase	Search...
Protein-protein interaction databases
STRING	199310.c0140.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN78636; AAN78636; c0140.
GeneID	1036476.
KEGG	ecc:c0140.
PATRIC	18278357. VBIEscCol75197_0134.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000273991.
KO	K05799.
OMA	RIRDCHA.
ProtClustDB	PRK09464.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011711. GntR_C. IPR000524. Tscrpt_reg_HTH_GntR. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF07729. FCD. 1 hit. PF00392. GntR. 1 hit. [Graphical view]
PRINTS	PR00035. HTHGNTR.
SMART	SM00895. FCD. 1 hit. SM00345. HTH_GNTR. 1 hit. [Graphical view]
PROSITE	PS50949. HTH_GNTR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDHR_ECOL6

Accession

Primary (citable) accession number: P0ACM0
Secondary accession number(s): P06957, Q53381

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1988
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program