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Protein

Pyruvate dehydrogenase complex repressor

Gene

pdhR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi37 – 56H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding transcription factor activity Source: EcoCyc
  • sequence-specific DNA binding Source: CollecTF

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG11088-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase complex repressor
Gene namesi
Name:pdhR
Synonyms:aceC, genA, yacB
Ordered Locus Names:b0113, JW0109
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11088 pdhR

Subcellular locationi

GO - Cellular componenti

  • protein-DNA complex Source: CollecTF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506621 – 254Pyruvate dehydrogenase complex repressorAdd BLAST254

Proteomic databases

PaxDbiP0ACL9
PRIDEiP0ACL9

Expressioni

Gene expression databases

CollecTFiEXPREG_00000860

Interactioni

Protein-protein interaction databases

BioGridi4260661, 9 interactors
IntActiP0ACL9, 8 interactors
STRINGi316385.ECDH10B_0093

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KVRX-ray1.36A1-75[»]
5TPMX-ray2.80A/B/C/D99-254[»]
ProteinModelPortaliP0ACL9
SMRiP0ACL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 77HTH gntR-typePROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiENOG41073TP Bacteria
COG2186 LUCA
HOGENOMiHOG000273991
InParanoidiP0ACL9
KOiK05799
OMAiMQYQIAV
PhylomeDBiP0ACL9

Family and domain databases

CDDicd07377 WHTH_GntR, 1 hit
Gene3Di1.10.10.10, 1 hit
1.20.120.530, 1 hit
InterProiView protein in InterPro
IPR011711 GntR_C
IPR008920 TF_FadR/GntR_C
IPR000524 Tscrpt_reg_HTH_GntR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF07729 FCD, 1 hit
PF00392 GntR, 1 hit
PRINTSiPR00035 HTHGNTR
SMARTiView protein in SMART
SM00895 FCD, 1 hit
SM00345 HTH_GNTR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48008 SSF48008, 1 hit
PROSITEiView protein in PROSITE
PS50949 HTH_GNTR, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYSKIRQPK LSDVIEQQLE FLILEGTLRP GEKLPPEREL AKQFDVSRPS
60 70 80 90 100
LREAIQRLEA KGLLLRRQGG GTFVQSSLWQ SFSDPLVELL SDHPESQYDL
110 120 130 140 150
LETRHALEGI AAYYAALRST DEDKERIREL HHAIELAQQS GDLDAESNAV
160 170 180 190 200
LQYQIAVTEA AHNVVLLHLL RCMEPMLAQN VRQNFELLYS RREMLPLVSS
210 220 230 240 250
HRTRIFEAIM AGKPEEAREA SHRHLAFIEE ILLDRSREES RRERSLRRLE

QRKN
Length:254
Mass (Da):29,425
Last modified:November 22, 2005 - v1
Checksum:iAF20245D3D3F751D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti118R → C in ACEC816; constitutively activated. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01498 Genomic DNA Translation: CAA24739.1
U00096 Genomic DNA Translation: AAC73224.1
AP009048 Genomic DNA Translation: BAB96683.2
S67363 Genomic DNA Translation: AAB29356.1
PIRiA64734 BVECA
RefSeqiNP_414655.1, NC_000913.3
WP_000331776.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73224; AAC73224; b0113
BAB96683; BAB96683; BAB96683
GeneIDi944827
KEGGiecj:JW0109
eco:b0113
PATRICifig|1411691.4.peg.2169

Similar proteinsi

Entry informationi

Entry nameiPDHR_ECOLI
AccessioniPrimary (citable) accession number: P0ACL9
Secondary accession number(s): P06957, Q53381, Q8KMZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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