Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative L-lactate dehydrogenase operon regulatory protein

Gene

lldR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a regulatory protein for the LCT genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi34 – 5320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • carbon catabolite regulation of transcription Source: EcoCyc
  • cellular response to DNA damage stimulus Source: EcoliWiki
  • single-species biofilm formation Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11962-MONOMER.
ECOL316407:JW3579-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-lactate dehydrogenase operon regulatory protein
Gene namesi
Name:lldR
Synonyms:lctR
Ordered Locus Names:b3604, JW3579
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11962. lldR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Putative L-lactate dehydrogenase operon regulatory proteinPRO_0000050652Add
BLAST

Proteomic databases

PaxDbiP0ACL7.
PRIDEiP0ACL7.

Expressioni

Inductioni

By L-lactate; aerobically.

Interactioni

Protein-protein interaction databases

BioGridi4260906. 7 interactions.
DIPiDIP-10110N.
IntActiP0ACL7. 5 interactions.
STRINGi511145.b3604.

Structurei

3D structure databases

ProteinModelPortaliP0ACL7.
SMRiP0ACL7. Positions 11-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7469HTH gntR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH gntR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41073TP. Bacteria.
COG2186. LUCA.
HOGENOMiHOG000273991.
InParanoidiP0ACL7.
KOiK14348.
OMAiDVTFHSM.
OrthoDBiEOG6M9DVM.
PhylomeDBiP0ACL7.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVLPRRLSD EVADRVRALI DEKNLEAGMK LPAERQLAMQ LGVSRNSLRE
60 70 80 90 100
ALAKLVSEGV LLSRRGGGTF IRWRHDTWSE QNIVQPLKTL MADDPDYSFD
110 120 130 140 150
ILEARYAIEA STAWHAAMRA TPGDKEKIQL CFEATLSEDP DIASQADVRF
160 170 180 190 200
HLAIAEASHN IVLLQTMRGF FDVLQSSVKH SRQRMYLVPP VFSQLTEQHQ
210 220 230 240 250
AVIDAIFAGD ADGARKAMMA HLSFVHTTMK RFDEDQARHA RITRLPGEHN

EHSREKNA
Length:258
Mass (Da):29,166
Last modified:November 22, 2005 - v1
Checksum:i59C4643B3456079E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13970 Unassigned DNA. Translation: AAA03584.1.
U00039 Genomic DNA. Translation: AAB18581.1.
U00096 Genomic DNA. Translation: AAC76628.1.
AP009048 Genomic DNA. Translation: BAE77688.1.
PIRiB49904.
RefSeqiNP_418061.1. NC_000913.3.
WP_000636500.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76628; AAC76628; b3604.
BAE77688; BAE77688; BAE77688.
GeneIDi948122.
KEGGiecj:JW3579.
eco:b3604.
PATRICi32122693. VBIEscCol129921_3723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13970 Unassigned DNA. Translation: AAA03584.1.
U00039 Genomic DNA. Translation: AAB18581.1.
U00096 Genomic DNA. Translation: AAC76628.1.
AP009048 Genomic DNA. Translation: BAE77688.1.
PIRiB49904.
RefSeqiNP_418061.1. NC_000913.3.
WP_000636500.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACL7.
SMRiP0ACL7. Positions 11-71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260906. 7 interactions.
DIPiDIP-10110N.
IntActiP0ACL7. 5 interactions.
STRINGi511145.b3604.

Proteomic databases

PaxDbiP0ACL7.
PRIDEiP0ACL7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76628; AAC76628; b3604.
BAE77688; BAE77688; BAE77688.
GeneIDi948122.
KEGGiecj:JW3579.
eco:b3604.
PATRICi32122693. VBIEscCol129921_3723.

Organism-specific databases

EchoBASEiEB1905.
EcoGeneiEG11962. lldR.

Phylogenomic databases

eggNOGiENOG41073TP. Bacteria.
COG2186. LUCA.
HOGENOMiHOG000273991.
InParanoidiP0ACL7.
KOiK14348.
OMAiDVTFHSM.
OrthoDBiEOG6M9DVM.
PhylomeDBiP0ACL7.

Enzyme and pathway databases

BioCyciEcoCyc:EG11962-MONOMER.
ECOL316407:JW3579-MONOMER.

Miscellaneous databases

PROiP0ACL7.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Three overlapping lct genes involved in L-lactate utilization by Escherichia coli."
    Dong J.M., Taylor J.S., Latour D.J., Iuchi S., Lin E.C.C.
    J. Bacteriol. 175:6671-6678(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
    Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
    Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiLLDR_ECOLI
AccessioniPrimary (citable) accession number: P0ACL7
Secondary accession number(s): P33233, Q2M7R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: January 20, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.