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Protein

Putative L-lactate dehydrogenase operon regulatory protein

Gene

lldR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a regulatory protein for the LCT genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi34 – 53H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • carbon catabolite regulation of transcription Source: EcoCyc
  • cellular response to DNA damage stimulus Source: EcoliWiki
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG11962-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-lactate dehydrogenase operon regulatory protein
Gene namesi
Name:lldR
Synonyms:lctR
Ordered Locus Names:b3604, JW3579
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11962. lldR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506521 – 258Putative L-lactate dehydrogenase operon regulatory proteinAdd BLAST258

Proteomic databases

PaxDbiP0ACL7.
PRIDEiP0ACL7.

Expressioni

Inductioni

By L-lactate; aerobically.

Interactioni

Protein-protein interaction databases

BioGridi4260906. 7 interactors.
DIPiDIP-10110N.
IntActiP0ACL7. 5 interactors.
STRINGi316385.ECDH10B_3786.

Structurei

3D structure databases

ProteinModelPortaliP0ACL7.
SMRiP0ACL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 74HTH gntR-typePROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiENOG41073TP. Bacteria.
COG2186. LUCA.
HOGENOMiHOG000273991.
InParanoidiP0ACL7.
KOiK14348.
PhylomeDBiP0ACL7.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiView protein in InterPro
IPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
PRINTSiPR00035. HTHGNTR.
SMARTiView protein in SMART
SM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiView protein in PROSITE
PS50949. HTH_GNTR. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVLPRRLSD EVADRVRALI DEKNLEAGMK LPAERQLAMQ LGVSRNSLRE
60 70 80 90 100
ALAKLVSEGV LLSRRGGGTF IRWRHDTWSE QNIVQPLKTL MADDPDYSFD
110 120 130 140 150
ILEARYAIEA STAWHAAMRA TPGDKEKIQL CFEATLSEDP DIASQADVRF
160 170 180 190 200
HLAIAEASHN IVLLQTMRGF FDVLQSSVKH SRQRMYLVPP VFSQLTEQHQ
210 220 230 240 250
AVIDAIFAGD ADGARKAMMA HLSFVHTTMK RFDEDQARHA RITRLPGEHN

EHSREKNA
Length:258
Mass (Da):29,166
Last modified:November 22, 2005 - v1
Checksum:i59C4643B3456079E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13970 Unassigned DNA. Translation: AAA03584.1.
U00039 Genomic DNA. Translation: AAB18581.1.
U00096 Genomic DNA. Translation: AAC76628.1.
AP009048 Genomic DNA. Translation: BAE77688.1.
PIRiB49904.
RefSeqiNP_418061.1. NC_000913.3.
WP_000636500.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76628; AAC76628; b3604.
BAE77688; BAE77688; BAE77688.
GeneIDi948122.
KEGGiecj:JW3579.
eco:b3604.
PATRICifig|1411691.4.peg.3102.

Similar proteinsi

Entry informationi

Entry nameiLLDR_ECOLI
AccessioniPrimary (citable) accession number: P0ACL7
Secondary accession number(s): P33233, Q2M7R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: August 30, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene