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Protein

Glc operon transcriptional activator

Gene

glcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Activator for the glycolate oxidation locus.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi34 – 5320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7546-MONOMER.
ECOL316407:JW2947-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glc operon transcriptional activator
Gene namesi
Name:glcC
Synonyms:yghN
Ordered Locus Names:b2980, JW2947
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12998. glcC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Glc operon transcriptional activatorPRO_0000050645Add
BLAST

Proteomic databases

PaxDbiP0ACL5.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hemLP238934EBI-1115389,EBI-909193
yedSP763352EBI-1115389,EBI-1119674

Protein-protein interaction databases

BioGridi4262369. 17 interactions.
IntActiP0ACL5. 65 interactions.
STRINGi511145.b2980.

Structurei

3D structure databases

ProteinModelPortaliP0ACL5.
SMRiP0ACL5. Positions 10-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7469HTH gntR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH gntR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108KWP. Bacteria.
COG2186. LUCA.
HOGENOMiHOG000273991.
InParanoidiP0ACL5.
KOiK11474.
OMAiMMHLLGS.
PhylomeDBiP0ACL5.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDERRPICE VVAESIERLI IDGVLKVGQP LPSERRLCEK LGFSRSALRE
60 70 80 90 100
GLTVLRGRGI IETAQGRDSR VARLNRVQDT SPLIHLFSTQ PRTLYDLLDV
110 120 130 140 150
RALLEGESAR LAATLGTQAD FVVITRCYEK MLAASENNKE ISLIEHAQLD
160 170 180 190 200
HAFHLAICQA SHNQVLVFTL QSLTDLMFNS VFASVNNLYH RPQQKKQIDR
210 220 230 240 250
QHARIYNAVL QRLPHVAQRA ARDHVRTVKK NLHDIELEGH HLIRSAVPLE

MNLS
Length:254
Mass (Da):28,826
Last modified:November 22, 2005 - v1
Checksum:i984C172F18886BF5
GO

Sequence cautioni

The sequence AAA69147 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43490 Genomic DNA. Translation: AAB02529.1.
U28377 Genomic DNA. Translation: AAA69147.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76016.1.
AP009048 Genomic DNA. Translation: BAE77041.1.
PIRiB65084.
RefSeqiNP_417454.1. NC_000913.3.
WP_001297764.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76016; AAC76016; b2980.
BAE77041; BAE77041; BAE77041.
GeneIDi947466.
KEGGiecj:JW2947.
eco:b2980.
PATRICi32121376. VBIEscCol129921_3075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43490 Genomic DNA. Translation: AAB02529.1.
U28377 Genomic DNA. Translation: AAA69147.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76016.1.
AP009048 Genomic DNA. Translation: BAE77041.1.
PIRiB65084.
RefSeqiNP_417454.1. NC_000913.3.
WP_001297764.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACL5.
SMRiP0ACL5. Positions 10-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262369. 17 interactions.
IntActiP0ACL5. 65 interactions.
STRINGi511145.b2980.

Proteomic databases

PaxDbiP0ACL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76016; AAC76016; b2980.
BAE77041; BAE77041; BAE77041.
GeneIDi947466.
KEGGiecj:JW2947.
eco:b2980.
PATRICi32121376. VBIEscCol129921_3075.

Organism-specific databases

EchoBASEiEB2821.
EcoGeneiEG12998. glcC.

Phylogenomic databases

eggNOGiENOG4108KWP. Bacteria.
COG2186. LUCA.
HOGENOMiHOG000273991.
InParanoidiP0ACL5.
KOiK11474.
OMAiMMHLLGS.
PhylomeDBiP0ACL5.

Enzyme and pathway databases

BioCyciEcoCyc:G7546-MONOMER.
ECOL316407:JW2947-MONOMER.

Miscellaneous databases

PROiP0ACL5.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLCC_ECOLI
AccessioniPrimary (citable) accession number: P0ACL5
Secondary accession number(s): P52072, Q2M9L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.