Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glc operon transcriptional activator

Gene

glcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activator for the glycolate oxidation locus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi34 – 53H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:G7546-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glc operon transcriptional activator
Gene namesi
Name:glcC
Synonyms:yghN
Ordered Locus Names:b2980, JW2947
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12998 glcC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506451 – 254Glc operon transcriptional activatorAdd BLAST254

Proteomic databases

PaxDbiP0ACL5
PRIDEiP0ACL5

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hemLP238934EBI-1115389,EBI-909193

Protein-protein interaction databases

BioGridi4262369, 17 interactors
IntActiP0ACL5, 65 interactors
STRINGi316385.ECDH10B_3157

Structurei

3D structure databases

ProteinModelPortaliP0ACL5
SMRiP0ACL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 74HTH gntR-typePROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiENOG4108KWP Bacteria
COG2186 LUCA
HOGENOMiHOG000273991
InParanoidiP0ACL5
KOiK11474
OMAiMMHLLGS
PhylomeDBiP0ACL5

Family and domain databases

CDDicd07377 WHTH_GntR, 1 hit
Gene3Di1.10.10.10, 1 hit
1.20.120.530, 1 hit
InterProiView protein in InterPro
IPR011711 GntR_C
IPR008920 TF_FadR/GntR_C
IPR000524 Tscrpt_reg_HTH_GntR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF07729 FCD, 1 hit
PF00392 GntR, 1 hit
PRINTSiPR00035 HTHGNTR
SMARTiView protein in SMART
SM00895 FCD, 1 hit
SM00345 HTH_GNTR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF48008 SSF48008, 1 hit
PROSITEiView protein in PROSITE
PS50949 HTH_GNTR, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDERRPICE VVAESIERLI IDGVLKVGQP LPSERRLCEK LGFSRSALRE
60 70 80 90 100
GLTVLRGRGI IETAQGRDSR VARLNRVQDT SPLIHLFSTQ PRTLYDLLDV
110 120 130 140 150
RALLEGESAR LAATLGTQAD FVVITRCYEK MLAASENNKE ISLIEHAQLD
160 170 180 190 200
HAFHLAICQA SHNQVLVFTL QSLTDLMFNS VFASVNNLYH RPQQKKQIDR
210 220 230 240 250
QHARIYNAVL QRLPHVAQRA ARDHVRTVKK NLHDIELEGH HLIRSAVPLE

MNLS
Length:254
Mass (Da):28,826
Last modified:November 22, 2005 - v1
Checksum:i984C172F18886BF5
GO

Sequence cautioni

The sequence AAA69147 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L43490 Genomic DNA Translation: AAB02529.1
U28377 Genomic DNA Translation: AAA69147.1 Different initiation.
U00096 Genomic DNA Translation: AAC76016.1
AP009048 Genomic DNA Translation: BAE77041.1
PIRiB65084
RefSeqiNP_417454.1, NC_000913.3
WP_001297764.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76016; AAC76016; b2980
BAE77041; BAE77041; BAE77041
GeneIDi947466
KEGGiecj:JW2947
eco:b2980
PATRICifig|1411691.4.peg.3750

Similar proteinsi

Entry informationi

Entry nameiGLCC_ECOLI
AccessioniPrimary (citable) accession number: P0ACL5
Secondary accession number(s): P52072, Q2M9L5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health