P0ACL5 (GLCC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glc operon transcriptional activator

Gene names

Name:	glcC
Synonyms:	yghN
Ordered Locus Names:	b2980, JW2947

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Activator for the glycolate oxidation locus.
Sequence similarities	Contains 1 HTH gntR-type DNA-binding domain.
Sequence caution	The sequence AAA69147.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from direct assay PubMed 9880556. Source: EcoCyc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from direct assay PubMed 9880556. Source: EcoCyc sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Glc operon transcriptional activator		PRO_0000050645
Regions
	Domain	6 – 74	69	HTH gntR-type
	DNA binding	34 – 53	20	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	P0ACL5 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 984C172F18886BF5	FASTA	254	28,826
	10 20 30 40 50 60 MKDERRPICE VVAESIERLI IDGVLKVGQP LPSERRLCEK LGFSRSALRE GLTVLRGRGI 70 80 90 100 110 120 IETAQGRDSR VARLNRVQDT SPLIHLFSTQ PRTLYDLLDV RALLEGESAR LAATLGTQAD 130 140 150 160 170 180 FVVITRCYEK MLAASENNKE ISLIEHAQLD HAFHLAICQA SHNQVLVFTL QSLTDLMFNS 190 200 210 220 230 240 VFASVNNLYH RPQQKKQIDR QHARIYNAVL QRLPHVAQRA ARDHVRTVKK NLHDIELEGH 250 HLIRSAVPLE MNLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"glc locus of Escherichia coli: characterization of genes encoding the subunits of glycolate oxidase and the glc regulator protein." Pellicer M.T., Badia J., Aguilar J.T., Baldoma L. J. Bacteriol. 178:2051-2059(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L43490 Genomic DNA. Translation: AAB02529.1. U28377 Genomic DNA. Translation: AAA69147.1. Different initiation. U00096 Genomic DNA. Translation: AAC76016.1. AP009048 Genomic DNA. Translation: BAE77041.1.
PIR	B65084.
RefSeq	NP_417454.1. NC_000913.2. YP_491177.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0ACL5.
SMR	P0ACL5. Positions 10-225.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0ACL5. 9 interactions.
STRING	511145.b2980.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC76016; AAC76016; b2980. BAE77041; BAE77041; BAE77041.
GeneID	12933375. 947466.
KEGG	ecj:Y75_p2909. eco:b2980.
PATRIC	32121376. VBIEscCol129921_3075.
Organism-specific databases
EchoBASE	EB2821.
EcoGene	EG12998. glcC.
Phylogenomic databases
eggNOG	COG2186.
HOGENOM	HOG000273991.
KO	K11474.
OMA	NLYHREP.
ProtClustDB	PRK09990.
Enzyme and pathway databases
BioCyc	EcoCyc:G7546-MONOMER. ECOL316407:JW2947-MONOMER.
Gene expression databases
Genevestigator	P0ACL5.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 1.20.120.530. 1 hit.
InterPro	IPR027376. FadR/GntR_C. IPR011711. GntR_C. IPR000524. Tscrpt_reg_HTH_GntR. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF07729. FCD. 1 hit. PF00392. GntR. 1 hit. [Graphical view]
PRINTS	PR00035. HTHGNTR.
SMART	SM00895. FCD. 1 hit. SM00345. HTH_GNTR. 1 hit. [Graphical view]
PROSITE	PS50949. HTH_GNTR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLCC_ECOLI

Accession

Primary (citable) accession number: P0ACL5
Secondary accession number(s): P52072, Q2M9L5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program