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Protein

Exu regulon transcriptional regulator

Gene

exuR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi35 – 54H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD03270.
ECOL316407:JW3065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exu regulon transcriptional regulator
Gene namesi
Name:exuR
Ordered Locus Names:b3094, JW3065
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12739. exuR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000506221 – 258Exu regulon transcriptional regulatorAdd BLAST258

Proteomic databases

PaxDbiP0ACL2.
PRIDEiP0ACL2.

Interactioni

Protein-protein interaction databases

BioGridi4262410. 9 interactors.
IntActiP0ACL2. 3 interactors.
STRINGi511145.b3094.

Structurei

3D structure databases

ProteinModelPortaliP0ACL2.
SMRiP0ACL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 75HTH gntR-typePROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Contains 1 HTH gntR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107YCY. Bacteria.
COG2186. LUCA.
HOGENOMiHOG000273991.
InParanoidiP0ACL2.
KOiK19775.
OMAiYLFADNP.
PhylomeDBiP0ACL2.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEITEPRRLY QQLAADLKER IEQGVYLVGD KLPAERFIAD EKNVSRTVVR
60 70 80 90 100
EAIIMLEVEG YVEVRKGSGI HVVSNQPRHQ QAADNNMEFA NYGPFELLQA
110 120 130 140 150
RQLIESNIAE FAATQVTKQD IMKLMAIQEQ ARGEQCFRDS EWDLQFHIQV
160 170 180 190 200
ALATQNSALA AIVEKMWTQR SHNPYWKKLH EHIDSRTVDN WCDDHDQILK
210 220 230 240 250
ALIRKDPHAA KLAMWQHLEN TKIMLFNETS DDFEFNADRY LFAENPVVHL

DTATSGSK
Length:258
Mass (Da):29,836
Last modified:November 22, 2005 - v1
Checksum:i689758815BC501FD
GO

Sequence cautioni

The sequence AAA57898 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13328 Genomic DNA. Translation: BAA02589.1.
U18997 Genomic DNA. Translation: AAA57898.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76129.2.
AP009048 Genomic DNA. Translation: BAE77144.1.
PIRiC65098.
RefSeqiNP_417565.2. NC_000913.3.
WP_000406488.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76129; AAC76129; b3094.
BAE77144; BAE77144; BAE77144.
GeneIDi947602.
KEGGiecj:JW3065.
eco:b3094.
PATRICi32121606. VBIEscCol129921_3189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13328 Genomic DNA. Translation: BAA02589.1.
U18997 Genomic DNA. Translation: AAA57898.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76129.2.
AP009048 Genomic DNA. Translation: BAE77144.1.
PIRiC65098.
RefSeqiNP_417565.2. NC_000913.3.
WP_000406488.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACL2.
SMRiP0ACL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262410. 9 interactors.
IntActiP0ACL2. 3 interactors.
STRINGi511145.b3094.

Proteomic databases

PaxDbiP0ACL2.
PRIDEiP0ACL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76129; AAC76129; b3094.
BAE77144; BAE77144; BAE77144.
GeneIDi947602.
KEGGiecj:JW3065.
eco:b3094.
PATRICi32121606. VBIEscCol129921_3189.

Organism-specific databases

EchoBASEiEB2595.
EcoGeneiEG12739. exuR.

Phylogenomic databases

eggNOGiENOG4107YCY. Bacteria.
COG2186. LUCA.
HOGENOMiHOG000273991.
InParanoidiP0ACL2.
KOiK19775.
OMAiYLFADNP.
PhylomeDBiP0ACL2.

Enzyme and pathway databases

BioCyciEcoCyc:PD03270.
ECOL316407:JW3065-MONOMER.

Miscellaneous databases

PROiP0ACL2.

Family and domain databases

CDDicd07377. WHTH_GntR. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.20.120.530. 1 hit.
InterProiIPR011711. GntR_C.
IPR008920. TF_FadR/GntR_C.
IPR000524. Tscrpt_reg_HTH_GntR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07729. FCD. 1 hit.
PF00392. GntR. 1 hit.
[Graphical view]
PRINTSiPR00035. HTHGNTR.
SMARTiSM00895. FCD. 1 hit.
SM00345. HTH_GNTR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF48008. SSF48008. 1 hit.
PROSITEiPS50949. HTH_GNTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEXUR_ECOLI
AccessioniPrimary (citable) accession number: P0ACL2
Secondary accession number(s): P42608
, P76665, Q2M9B2, Q8X4Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.