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Protein

Glycerol-3-phosphate regulon repressor

Gene

glpR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of the glycerol-3-phosphate regulon.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi20 – 3920H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Glycerol metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD03576.
ECOL316407:JW3386-MONOMER.
RETL1328306-WGS:GSTH-4099-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate regulon repressor
Gene namesi
Name:glpR
Ordered Locus Names:b3423, JW3386
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10400. glpR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Glycerol-3-phosphate regulon repressorPRO_0000050251Add
BLAST

Proteomic databases

EPDiP0ACL0.
PaxDbiP0ACL0.
PRIDEiP0ACL0.

2D gel databases

SWISS-2DPAGEP0ACL0.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ttdAP058472EBI-1123685,EBI-1113137

Protein-protein interaction databases

BioGridi4261187. 15 interactions.
DIPiDIP-9798N.
IntActiP0ACL0. 2 interactions.
STRINGi511145.b3423.

Structurei

3D structure databases

ProteinModelPortaliP0ACL0.
SMRiP0ACL0. Positions 3-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 5856HTH deoR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH deoR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E98. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000224685.
InParanoidiP0ACL0.
KOiK02444.
OMAiNLAYEAR.
PhylomeDBiP0ACL0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
PRINTSiPR00037. HTHLACR.
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQTQRHNGI IELVKQQGYV STEELVEHFS VSPQTIRRDL NELAEQNLIL
60 70 80 90 100
RHHGGAALPS SSVNTPWHDR KATQTEEKER IARKVAEQIP NGSTLFIDIG
110 120 130 140 150
TTPEAVAHAL LNHSNLRIVT NNLNVANTLM VKEDFRIILA GGELRSRDGG
160 170 180 190 200
IIGEATLDFI SQFRLDFGIL GISGIDSDGS LLEFDYHEVR TKRAIIENSR
210 220 230 240 250
HVMLVVDHSK FGRNAMVNMG SISMVDAVYT DAPPPVSVMQ VLTDHHIQLE

LC
Length:252
Mass (Da):28,048
Last modified:November 22, 2005 - v1
Checksum:iD547569200AFB6B3
GO

Sequence cautioni

The sequence CAA30399 differs from that shown. Reason: Frameshift at positions 107, 148, 165 and 233. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 1551A → R (PubMed:3045764).Curated
Sequence conflicti235 – 2351P → PP (PubMed:3045764).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96795 Genomic DNA. Translation: AAC28167.1.
X07520 Genomic DNA. Translation: CAA30399.1. Frameshift.
U18997 Genomic DNA. Translation: AAA58221.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE77869.1.
PIRiB65138.
RefSeqiWP_000815099.1. NZ_CP014272.1.

Genome annotation databases

EnsemblBacteriaiBAE77869; BAE77869; BAE77869.
KEGGiecj:JW3386.
PATRICi32122282. VBIEscCol129921_3518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96795 Genomic DNA. Translation: AAC28167.1.
X07520 Genomic DNA. Translation: CAA30399.1. Frameshift.
U18997 Genomic DNA. Translation: AAA58221.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE77869.1.
PIRiB65138.
RefSeqiWP_000815099.1. NZ_CP014272.1.

3D structure databases

ProteinModelPortaliP0ACL0.
SMRiP0ACL0. Positions 3-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261187. 15 interactions.
DIPiDIP-9798N.
IntActiP0ACL0. 2 interactions.
STRINGi511145.b3423.

2D gel databases

SWISS-2DPAGEP0ACL0.

Proteomic databases

EPDiP0ACL0.
PaxDbiP0ACL0.
PRIDEiP0ACL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE77869; BAE77869; BAE77869.
KEGGiecj:JW3386.
PATRICi32122282. VBIEscCol129921_3518.

Organism-specific databases

EchoBASEiEB0395.
EcoGeneiEG10400. glpR.

Phylogenomic databases

eggNOGiENOG4105E98. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000224685.
InParanoidiP0ACL0.
KOiK02444.
OMAiNLAYEAR.
PhylomeDBiP0ACL0.

Enzyme and pathway databases

BioCyciEcoCyc:PD03576.
ECOL316407:JW3386-MONOMER.
RETL1328306-WGS:GSTH-4099-MONOMER.

Miscellaneous databases

PROiP0ACL0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
PRINTSiPR00037. HTHLACR.
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPR_ECOLI
AccessioniPrimary (citable) accession number: P0ACL0
Secondary accession number(s): P09392, Q2M787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

A pseudogene in strain MG1655 / ATCC 700926 due to a recent laboratory-derived single nucleotide deletion, but not its parent MG1655 / ATCC 47076.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.