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Protein

Glycerol-3-phosphate regulon repressor

Gene

glpR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Repressor of the glycerol-3-phosphate regulon.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi20 – 39H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processGlycerol metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD03576.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate regulon repressor
Gene namesi
Name:glpR
Ordered Locus Names:b3423, JW3386
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10400. glpR.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502511 – 252Glycerol-3-phosphate regulon repressorAdd BLAST252

Proteomic databases

PaxDbiP0ACL0.
PRIDEiP0ACL0.

2D gel databases

SWISS-2DPAGEiP0ACL0.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ttdAP058472EBI-1123685,EBI-1113137

Protein-protein interaction databases

BioGridi4261187. 15 interactors.
DIPiDIP-9798N.
IntActiP0ACL0. 2 interactors.
STRINGi316385.ECDH10B_3597.

Structurei

3D structure databases

ProteinModelPortaliP0ACL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 58HTH deoR-typePROSITE-ProRule annotationAdd BLAST56

Phylogenomic databases

eggNOGiENOG4105E98. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000224685.
InParanoidiP0ACL0.
KOiK02444.
PhylomeDBiP0ACL0.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
PRINTSiPR00037. HTHLACR.
SMARTiView protein in SMART
SM00420. HTH_DEOR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQTQRHNGI IELVKQQGYV STEELVEHFS VSPQTIRRDL NELAEQNLIL
60 70 80 90 100
RHHGGAALPS SSVNTPWHDR KATQTEEKER IARKVAEQIP NGSTLFIDIG
110 120 130 140 150
TTPEAVAHAL LNHSNLRIVT NNLNVANTLM VKEDFRIILA GGELRSRDGG
160 170 180 190 200
IIGEATLDFI SQFRLDFGIL GISGIDSDGS LLEFDYHEVR TKRAIIENSR
210 220 230 240 250
HVMLVVDHSK FGRNAMVNMG SISMVDAVYT DAPPPVSVMQ VLTDHHIQLE

LC
Length:252
Mass (Da):28,048
Last modified:November 22, 2005 - v1
Checksum:iD547569200AFB6B3
GO

Sequence cautioni

The sequence CAA30399 differs from that shown. Reason: Frameshift at positions 107, 148, 165 and 233.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155A → R (PubMed:3045764).Curated1
Sequence conflicti235P → PP (PubMed:3045764).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96795 Genomic DNA. Translation: AAC28167.1.
X07520 Genomic DNA. Translation: CAA30399.1. Frameshift.
U18997 Genomic DNA. Translation: AAA58221.1.
U00096 Genomic DNA. No translation available.
AP009048 Genomic DNA. Translation: BAE77869.1.
PIRiB65138.
RefSeqiWP_000815099.1. NZ_CP014272.1.

Genome annotation databases

EnsemblBacteriaiBAE77869; BAE77869; BAE77869.
KEGGiecj:JW3386.
PATRICifig|83333.103.peg.4322.

Similar proteinsi

Entry informationi

Entry nameiGLPR_ECOLI
AccessioniPrimary (citable) accession number: P0ACL0
Secondary accession number(s): P09392, Q2M787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

A pseudogene in strain MG1655 / ATCC 700926 due to a recent laboratory-derived single nucleotide deletion, but not its parent MG1655 / ATCC 47076.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene