Reviewed, UniProtKB/Swiss-Prot P0ACK5 (DEOR_ECOLI)

Names and origin

Protein names

Recommended name:
    Deoxyribose operon repressor

Gene names

Name:	deoR
Synonyms:	nucR
Ordered Locus Names:	b0840, JW0824

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore-forming protein). The inducer is deoxyribose-5-phosphate.
Subunit structure	Homooctamer Probable.
Sequence similarities	Contains 1 HTH deoR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Deoxyribose operon repressor		PRO_0000050244
Regions
	Domain	5 – 57	53	HTH deoR-type
	DNA binding	22 – 41	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0ACK5-1 [UniParc]. Last modified January 1, 1988. Version 1. Checksum: 69D20CEC86080233	FASTA	252	28,548
	10 20 30 40 50 60 METRREERIG QLLQELKRSD KLHLKDAAAL LGVSEMTIRR DLNNHSAPVV LLGGYIVLEP 70 80 90 100 110 120 RSASHYLLSD QKSRLVEEKR RAAKLAATLV EPDQTLFFDC GTTTPWIIEA IDNEIPFTAV 130 140 150 160 170 180 CYSLNTFLAL KEKPHCRAFL CGGEFHASNA IFKPIDFQQT LNNFCPDIAF YSAAGVHVSK 190 200 210 220 230 240 GATCFNLEEL PVKHWAMSMA QKHVLVVDHS KFGKVRPARM GDLKRFDIVV SDCCPEDEYV 250 KYAQTQRIKL MY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The primary structure of the DeoR repressor from Escherichia coli K-12." Valentin-Hansen P., Hoejrup P., Short S. Nucleic Acids Res. 13:5927-5936(1985) [PubMed: 2994018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed: 8905232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Purification and characterization of the deoR repressor of Escherichia coli." Mortensen L., Dandanell G., Hammer K. EMBO J. 8:325-331(1989) [PubMed: 2653814] [Abstract] Cited for: SUBUNIT.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X02837 Genomic DNA. Translation: CAA26598.1. U00096 Genomic DNA. Translation: AAC73927.1. AP009048 Genomic DNA. Translation: BAA35543.1.
PIR	RPECDO. A24076.
RefSeq	AP_001471.1. NP_415361.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	945453.
GenomeReviews	Gene locus JW0824 in contig AP009048_GR. Gene locus b0840 in contig U00096_GR.
KEGG	ecj:JW0824. eco:b0840.
Organism-specific databases
EchoBASE	EB0219.
EcoGene	EG10223. deoR.
CMR	Search...
Phylogenomic databases
HOGENOM	P0ACK5.
OMA	P0ACK5. CRVILCG.
Enzyme and pathway databases
BioCyc	EcoCyc:PD01196.
Family and domain databases
InterPro	IPR014036. HTH_DeoR. IPR001034. HTH_DeoR_N. IPR018356. Tscrpt_reg_HTH_DeoR_CS. [Graphical view]
Pfam	PF00455. DeoR. 1 hit. PF08220. HTH_DeoR. 1 hit. [Graphical view]
SMART	SM00420. HTH_DEOR. 1 hit. [Graphical view]
PROSITE	PS00894. HTH_DEOR_1. 1 hit. PS51000. HTH_DEOR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DEOR_ECOLI

Accession

Primary (citable) accession number: P0ACK5
Secondary accession number(s): P06217

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)