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Protein

Deoxyribose operon repressor

Gene

deoR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore-forming protein). The inducer is deoxyribose-5-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi22 – 41H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • negative regulation of DNA-templated transcription, initiation Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD01196

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose operon repressor
Gene namesi
Name:deoR
Synonyms:nucR
Ordered Locus Names:b0840, JW0824
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10223 deoR

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502441 – 252Deoxyribose operon repressorAdd BLAST252

Proteomic databases

PaxDbiP0ACK5
PRIDEiP0ACK5

Interactioni

Subunit structurei

Homooctamer.1 Publication

Protein-protein interaction databases

BioGridi4262826, 9 interactors
DIPiDIP-9430N
IntActiP0ACK5, 4 interactors
STRINGi316385.ECDH10B_0909

Structurei

3D structure databases

ProteinModelPortaliP0ACK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 57HTH deoR-typePROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiENOG4107FB0 Bacteria
COG1349 LUCA
HOGENOMiHOG000267839
KOiK11534
OMAiSCKGFDI
PhylomeDBiP0ACK5

Family and domain databases

InterProiView protein in InterPro
IPR014036 DeoR_C
IPR001034 DeoR_HTH
IPR037171 NagB/RpiA_transferase-like
IPR018356 Tscrpt_reg_HTH_DeoR_CS
PfamiView protein in Pfam
PF00455 DeoRC, 1 hit
PF08220 HTH_DeoR, 1 hit
SMARTiView protein in SMART
SM00420 HTH_DEOR, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
PROSITEiView protein in PROSITE
PS00894 HTH_DEOR_1, 1 hit
PS51000 HTH_DEOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRREERIG QLLQELKRSD KLHLKDAAAL LGVSEMTIRR DLNNHSAPVV
60 70 80 90 100
LLGGYIVLEP RSASHYLLSD QKSRLVEEKR RAAKLAATLV EPDQTLFFDC
110 120 130 140 150
GTTTPWIIEA IDNEIPFTAV CYSLNTFLAL KEKPHCRAFL CGGEFHASNA
160 170 180 190 200
IFKPIDFQQT LNNFCPDIAF YSAAGVHVSK GATCFNLEEL PVKHWAMSMA
210 220 230 240 250
QKHVLVVDHS KFGKVRPARM GDLKRFDIVV SDCCPEDEYV KYAQTQRIKL

MY
Length:252
Mass (Da):28,548
Last modified:January 1, 1988 - v1
Checksum:i69D20CEC86080233
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02837 Genomic DNA Translation: CAA26598.1
U00096 Genomic DNA Translation: AAC73927.1
AP009048 Genomic DNA Translation: BAA35543.1
PIRiA24076 RPECDO
RefSeqiNP_415361.1, NC_000913.3
WP_000450121.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73927; AAC73927; b0840
BAA35543; BAA35543; BAA35543
GeneIDi945453
KEGGiecj:JW0824
eco:b0840
PATRICifig|1411691.4.peg.1438

Similar proteinsi

Entry informationi

Entry nameiDEOR_ECOLI
AccessioniPrimary (citable) accession number: P0ACK5
Secondary accession number(s): P06217
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health