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Protein

Deoxyribose operon repressor

Gene

deoR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore-forming protein). The inducer is deoxyribose-5-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi22 – 41H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • negative regulation of DNA-templated transcription, initiation Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD01196.
ECOL316407:JW0824-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose operon repressor
Gene namesi
Name:deoR
Synonyms:nucR
Ordered Locus Names:b0840, JW0824
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10223. deoR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502441 – 252Deoxyribose operon repressorAdd BLAST252

Proteomic databases

PaxDbiP0ACK5.
PRIDEiP0ACK5.

Interactioni

Subunit structurei

Homooctamer.1 Publication

Protein-protein interaction databases

BioGridi4262826. 7 interactors.
DIPiDIP-9430N.
IntActiP0ACK5. 4 interactors.
STRINGi511145.b0840.

Structurei

3D structure databases

ProteinModelPortaliP0ACK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 57HTH deoR-typePROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 HTH deoR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107FB0. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000267839.
KOiK11534.
OMAiELEMKHR.
PhylomeDBiP0ACK5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METRREERIG QLLQELKRSD KLHLKDAAAL LGVSEMTIRR DLNNHSAPVV
60 70 80 90 100
LLGGYIVLEP RSASHYLLSD QKSRLVEEKR RAAKLAATLV EPDQTLFFDC
110 120 130 140 150
GTTTPWIIEA IDNEIPFTAV CYSLNTFLAL KEKPHCRAFL CGGEFHASNA
160 170 180 190 200
IFKPIDFQQT LNNFCPDIAF YSAAGVHVSK GATCFNLEEL PVKHWAMSMA
210 220 230 240 250
QKHVLVVDHS KFGKVRPARM GDLKRFDIVV SDCCPEDEYV KYAQTQRIKL

MY
Length:252
Mass (Da):28,548
Last modified:January 1, 1988 - v1
Checksum:i69D20CEC86080233
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02837 Genomic DNA. Translation: CAA26598.1.
U00096 Genomic DNA. Translation: AAC73927.1.
AP009048 Genomic DNA. Translation: BAA35543.1.
PIRiA24076. RPECDO.
RefSeqiNP_415361.1. NC_000913.3.
WP_000450121.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73927; AAC73927; b0840.
BAA35543; BAA35543; BAA35543.
GeneIDi945453.
KEGGiecj:JW0824.
eco:b0840.
PATRICi32116883. VBIEscCol129921_0867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02837 Genomic DNA. Translation: CAA26598.1.
U00096 Genomic DNA. Translation: AAC73927.1.
AP009048 Genomic DNA. Translation: BAA35543.1.
PIRiA24076. RPECDO.
RefSeqiNP_415361.1. NC_000913.3.
WP_000450121.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262826. 7 interactors.
DIPiDIP-9430N.
IntActiP0ACK5. 4 interactors.
STRINGi511145.b0840.

Proteomic databases

PaxDbiP0ACK5.
PRIDEiP0ACK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73927; AAC73927; b0840.
BAA35543; BAA35543; BAA35543.
GeneIDi945453.
KEGGiecj:JW0824.
eco:b0840.
PATRICi32116883. VBIEscCol129921_0867.

Organism-specific databases

EchoBASEiEB0219.
EcoGeneiEG10223. deoR.

Phylogenomic databases

eggNOGiENOG4107FB0. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000267839.
KOiK11534.
OMAiELEMKHR.
PhylomeDBiP0ACK5.

Enzyme and pathway databases

BioCyciEcoCyc:PD01196.
ECOL316407:JW0824-MONOMER.

Miscellaneous databases

PROiP0ACK5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEOR_ECOLI
AccessioniPrimary (citable) accession number: P0ACK5
Secondary accession number(s): P06217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.