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Protein

Putative aga operon transcriptional repressor

Gene

agaR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable repressor for the aga operon for N-acetyl galactosamine transport and metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi32 – 51H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7630-MONOMER.
ECOL316407:JW3100-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aga operon transcriptional repressor
Gene namesi
Name:agaR
Synonyms:yhaW
Ordered Locus Names:b3131, JW3100
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12762. agaR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000502411 – 269Putative aga operon transcriptional repressorAdd BLAST269

Proteomic databases

PaxDbiP0ACK2.
PRIDEiP0ACK2.

Interactioni

Protein-protein interaction databases

BioGridi4262414. 8 interactors.
DIPiDIP-48095N.
IntActiP0ACK2. 4 interactors.
MINTiMINT-1304785.
STRINGi511145.b3131.

Structurei

3D structure databases

ProteinModelPortaliP0ACK2.
SMRiP0ACK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 70HTH deoR-typePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Contains 1 HTH deoR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E98. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000224684.
InParanoidiP0ACK2.
KOiK02081.
OMAiKMCEVAE.
PhylomeDBiP0ACK2.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTDASGEK RVTGTSERRE QIIQRLRQQG SVQVNDLSAL YGVSTVTIRN
60 70 80 90 100
DLAFLEKQGI AVRAYGGALI CDSTTPSVEP SVEDKSALNT AMKRSVAKAA
110 120 130 140 150
VELIQPGHRV ILDSGTTTFE IARLMRKHTD VIAMTNGMNV ANALLEAEGV
160 170 180 190 200
ELLMTGGHLR RQSQSFYGDQ AEQSLQNYHF DMLFLGVDAI DLERGVSTHN
210 220 230 240 250
EDEARLNRRM CEVAERIIVV TDSSKFNRSS LHKIIDTQRI DMIIVDEGIP
260
ADSLEGLRKA GVEVILVGE
Length:269
Mass (Da):29,572
Last modified:November 22, 2005 - v1
Checksum:i73B5C19B357AE014
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228498 Genomic DNA. Translation: AAF81081.1.
U18997 Genomic DNA. Translation: AAA57934.1.
U00096 Genomic DNA. Translation: AAC76165.1.
AP009048 Genomic DNA. Translation: BAE77178.1.
PIRiG65102.
RefSeqiNP_417600.1. NC_000913.3.
WP_000072187.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76165; AAC76165; b3131.
BAE77178; BAE77178; BAE77178.
GeneIDi947636.
KEGGiecj:JW3100.
eco:b3131.
PATRICi32121678. VBIEscCol129921_3225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228498 Genomic DNA. Translation: AAF81081.1.
U18997 Genomic DNA. Translation: AAA57934.1.
U00096 Genomic DNA. Translation: AAC76165.1.
AP009048 Genomic DNA. Translation: BAE77178.1.
PIRiG65102.
RefSeqiNP_417600.1. NC_000913.3.
WP_000072187.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACK2.
SMRiP0ACK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262414. 8 interactors.
DIPiDIP-48095N.
IntActiP0ACK2. 4 interactors.
MINTiMINT-1304785.
STRINGi511145.b3131.

Proteomic databases

PaxDbiP0ACK2.
PRIDEiP0ACK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76165; AAC76165; b3131.
BAE77178; BAE77178; BAE77178.
GeneIDi947636.
KEGGiecj:JW3100.
eco:b3131.
PATRICi32121678. VBIEscCol129921_3225.

Organism-specific databases

EchoBASEiEB2615.
EcoGeneiEG12762. agaR.

Phylogenomic databases

eggNOGiENOG4105E98. Bacteria.
COG1349. LUCA.
HOGENOMiHOG000224684.
InParanoidiP0ACK2.
KOiK02081.
OMAiKMCEVAE.
PhylomeDBiP0ACK2.

Enzyme and pathway databases

BioCyciEcoCyc:G7630-MONOMER.
ECOL316407:JW3100-MONOMER.

Miscellaneous databases

PROiP0ACK2.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR014036. DeoR_C.
IPR001034. DeoR_HTH.
IPR018356. Tscrpt_reg_HTH_DeoR_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00455. DeoRC. 1 hit.
PF08220. HTH_DeoR. 1 hit.
[Graphical view]
SMARTiSM00420. HTH_DEOR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00894. HTH_DEOR_1. 1 hit.
PS51000. HTH_DEOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGAR_ECOLI
AccessioniPrimary (citable) accession number: P0ACK2
Secondary accession number(s): P42902, Q2M978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.