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Protein

Regulatory protein AsnC

Gene

asnC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi25 – 44H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • amino acid binding Source: EcoCyc
  • DNA binding transcription factor activity Source: EcoCyc
  • sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • response to amino acid Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00250

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein AsnC
Gene namesi
Name:asnC
Ordered Locus Names:b3743, JW3721
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10093 asnC

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001117191 – 152Regulatory protein AsnCAdd BLAST152

Proteomic databases

PaxDbiP0ACI6
PRIDEiP0ACI6

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hchAP316582EBI-1133670,EBI-909144

Protein-protein interaction databases

BioGridi4263262, 98 interactors
DIPiDIP-9178N
IntActiP0ACI6, 1 interactor
STRINGi316385.ECDH10B_3931

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 19Combined sources12
Helixi25 – 32Combined sources8
Helixi36 – 48Combined sources13
Beta strandi51 – 59Combined sources9
Turni61 – 65Combined sources5
Beta strandi68 – 78Combined sources11
Helixi79 – 81Combined sources3
Helixi82 – 90Combined sources9
Beta strandi95 – 104Combined sources10
Beta strandi106 – 114Combined sources9
Helixi116 – 125Combined sources10
Turni126 – 129Combined sources4
Beta strandi133 – 140Combined sources8
Beta strandi142 – 147Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CG4X-ray2.40A/B1-152[»]
ProteinModelPortaliP0ACI6
SMRiP0ACI6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACI6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 67HTH asnC-typePROSITE-ProRule annotationAdd BLAST62

Phylogenomic databases

eggNOGiENOG4108VVK Bacteria
COG1522 LUCA
HOGENOMiHOG000115326
InParanoidiP0ACI6
KOiK03718
OMAiLDERIVH
PhylomeDBiP0ACI6

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR000485 AsnC-type_HTH_dom
IPR011008 Dimeric_a/b-barrel
IPR019888 Tscrpt_reg_AsnC-typ
IPR019887 Tscrpt_reg_AsnC/Lrp_C
IPR019885 Tscrpt_reg_HTH_AsnC-type_CS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01037 AsnC_trans_reg, 1 hit
PRINTSiPR00033 HTHASNC
SMARTiView protein in SMART
SM00344 HTH_ASNC, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54909 SSF54909, 1 hit
PROSITEiView protein in PROSITE
PS00519 HTH_ASNC_1, 1 hit
PS50956 HTH_ASNC_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYLIDNLD RGILEALMGN ARTAYAELAK QFGVSPGTIH VRVEKMKQAG
60 70 80 90 100
IITGARIDVS PKQLGYDVGC FIGIILKSAK DYPSALAKLE SLDEVTEAYY
110 120 130 140 150
TTGHYSIFIK VMCRSIDALQ HVLINKIQTI DEIQSTETLI VLQNPIMRTI

KP
Length:152
Mass (Da):16,888
Last modified:July 21, 1986 - v1
Checksum:iB37581D88D15ECED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00263 Genomic DNA No translation available.
K00826 Genomic DNA Translation: AAA24252.1
L10328 Genomic DNA Translation: AAA62095.1
U00096 Genomic DNA Translation: AAC76766.1
AP009048 Genomic DNA Translation: BAE77545.1
PIRiA04434 QQECE1
RefSeqiNP_418199.1, NC_000913.3
WP_000432970.1, NZ_LN832404.1
YP_006952152.1, NC_019049.1

Genome annotation databases

EnsemblBacteriaiAAC76766; AAC76766; b3743
BAE77545; BAE77545; BAE77545
GeneIDi13909070
948259
KEGGiecj:JW3721
eco:b3743
PATRICifig|1411691.4.peg.2957

Similar proteinsi

Entry informationi

Entry nameiASNC_ECOLI
AccessioniPrimary (citable) accession number: P0ACI6
Secondary accession number(s): P03809, Q2M861
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health