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Protein

Regulatory protein AsnC

Gene

asnC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi25 – 44H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • amino acid binding Source: EcoCyc
  • sequence-specific DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • response to amino acid Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00250.
ECOL316407:JW3721-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein AsnC
Gene namesi
Name:asnC
Ordered Locus Names:b3743, JW3721
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10093. asnC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001117191 – 152Regulatory protein AsnCAdd BLAST152

Proteomic databases

PaxDbiP0ACI6.
PRIDEiP0ACI6.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hchAP316582EBI-1133670,EBI-909144

Protein-protein interaction databases

BioGridi4263262. 98 interactors.
DIPiDIP-9178N.
IntActiP0ACI6. 1 interactor.
STRINGi511145.b3743.

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 19Combined sources12
Helixi25 – 32Combined sources8
Helixi36 – 48Combined sources13
Beta strandi51 – 59Combined sources9
Turni61 – 65Combined sources5
Beta strandi68 – 78Combined sources11
Helixi79 – 81Combined sources3
Helixi82 – 90Combined sources9
Beta strandi95 – 104Combined sources10
Beta strandi106 – 114Combined sources9
Helixi116 – 125Combined sources10
Turni126 – 129Combined sources4
Beta strandi133 – 140Combined sources8
Beta strandi142 – 147Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CG4X-ray2.40A/B1-152[»]
ProteinModelPortaliP0ACI6.
SMRiP0ACI6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACI6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 67HTH asnC-typePROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Contains 1 HTH asnC-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108VVK. Bacteria.
COG1522. LUCA.
HOGENOMiHOG000115326.
InParanoidiP0ACI6.
KOiK03718.
OMAiLCRDNEH.
PhylomeDBiP0ACI6.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.920. 1 hit.
InterProiIPR000485. AsnC-type_HTH_dom.
IPR011008. Dimeric_a/b-barrel.
IPR019888. Tscrpt_reg_AsnC-typ.
IPR019887. Tscrpt_reg_AsnC/Lrp_C.
IPR019885. Tscrpt_reg_HTH_AsnC-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01037. AsnC_trans_reg. 1 hit.
[Graphical view]
PRINTSiPR00033. HTHASNC.
SMARTiSM00344. HTH_ASNC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54909. SSF54909. 1 hit.
PROSITEiPS00519. HTH_ASNC_1. 1 hit.
PS50956. HTH_ASNC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYLIDNLD RGILEALMGN ARTAYAELAK QFGVSPGTIH VRVEKMKQAG
60 70 80 90 100
IITGARIDVS PKQLGYDVGC FIGIILKSAK DYPSALAKLE SLDEVTEAYY
110 120 130 140 150
TTGHYSIFIK VMCRSIDALQ HVLINKIQTI DEIQSTETLI VLQNPIMRTI

KP
Length:152
Mass (Da):16,888
Last modified:July 21, 1986 - v1
Checksum:iB37581D88D15ECED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00263 Genomic DNA. No translation available.
K00826 Genomic DNA. Translation: AAA24252.1.
L10328 Genomic DNA. Translation: AAA62095.1.
U00096 Genomic DNA. Translation: AAC76766.1.
AP009048 Genomic DNA. Translation: BAE77545.1.
PIRiA04434. QQECE1.
RefSeqiNP_418199.1. NC_000913.3.
WP_000432970.1. NZ_LN832404.1.
YP_006952152.1. NC_019049.1.

Genome annotation databases

EnsemblBacteriaiAAC76766; AAC76766; b3743.
BAE77545; BAE77545; BAE77545.
GeneIDi13909070.
948259.
KEGGiecj:JW3721.
eco:b3743.
PATRICi32122985. VBIEscCol129921_3868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00263 Genomic DNA. No translation available.
K00826 Genomic DNA. Translation: AAA24252.1.
L10328 Genomic DNA. Translation: AAA62095.1.
U00096 Genomic DNA. Translation: AAC76766.1.
AP009048 Genomic DNA. Translation: BAE77545.1.
PIRiA04434. QQECE1.
RefSeqiNP_418199.1. NC_000913.3.
WP_000432970.1. NZ_LN832404.1.
YP_006952152.1. NC_019049.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CG4X-ray2.40A/B1-152[»]
ProteinModelPortaliP0ACI6.
SMRiP0ACI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263262. 98 interactors.
DIPiDIP-9178N.
IntActiP0ACI6. 1 interactor.
STRINGi511145.b3743.

Proteomic databases

PaxDbiP0ACI6.
PRIDEiP0ACI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76766; AAC76766; b3743.
BAE77545; BAE77545; BAE77545.
GeneIDi13909070.
948259.
KEGGiecj:JW3721.
eco:b3743.
PATRICi32122985. VBIEscCol129921_3868.

Organism-specific databases

EchoBASEiEB0091.
EcoGeneiEG10093. asnC.

Phylogenomic databases

eggNOGiENOG4108VVK. Bacteria.
COG1522. LUCA.
HOGENOMiHOG000115326.
InParanoidiP0ACI6.
KOiK03718.
OMAiLCRDNEH.
PhylomeDBiP0ACI6.

Enzyme and pathway databases

BioCyciEcoCyc:PD00250.
ECOL316407:JW3721-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ACI6.
PROiP0ACI6.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.920. 1 hit.
InterProiIPR000485. AsnC-type_HTH_dom.
IPR011008. Dimeric_a/b-barrel.
IPR019888. Tscrpt_reg_AsnC-typ.
IPR019887. Tscrpt_reg_AsnC/Lrp_C.
IPR019885. Tscrpt_reg_HTH_AsnC-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01037. AsnC_trans_reg. 1 hit.
[Graphical view]
PRINTSiPR00033. HTHASNC.
SMARTiSM00344. HTH_ASNC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54909. SSF54909. 1 hit.
PROSITEiPS00519. HTH_ASNC_1. 1 hit.
PS50956. HTH_ASNC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASNC_ECOLI
AccessioniPrimary (citable) accession number: P0ACI6
Secondary accession number(s): P03809, Q2M861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.