ID XYLR_ECOLI Reviewed; 392 AA. AC P0ACI3; P37390; Q2M7N2; DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 22-NOV-2005, sequence version 1. DT 24-JAN-2024, entry version 125. DE RecName: Full=Xylose operon regulatory protein; GN Name=xylR; OrderedLocusNames=b3569, JW3541; OS Escherichia coli (strain K12). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83333; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=8041620; DOI=10.1093/nar/22.13.2576; RA Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.; RT "Analysis of the Escherichia coli genome. V. DNA sequence of the region RT from 76.0 to 81.5 minutes."; RL Nucleic Acids Res. 22:2576-2586(1994). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / MG1655 / ATCC 47076; RX PubMed=9278503; DOI=10.1126/science.277.5331.1453; RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., RA Shao Y.; RT "The complete genome sequence of Escherichia coli K-12."; RL Science 277:1453-1462(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911; RX PubMed=16738553; DOI=10.1038/msb4100049; RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.; RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 RT and W3110."; RL Mol. Syst. Biol. 2:E1-E5(2006). CC -!- FUNCTION: Regulatory protein for the xylBAFGHR operon. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U00039; AAB18546.1; -; Genomic_DNA. DR EMBL; U00096; AAC76593.1; -; Genomic_DNA. DR EMBL; AP009048; BAE77724.1; -; Genomic_DNA. DR PIR; S47790; S47790. DR RefSeq; NP_418026.1; NC_000913.3. DR RefSeq; WP_000494484.1; NZ_STEB01000018.1. DR PDB; 4FE4; X-ray; 3.45 A; A/B/C=1-392. DR PDB; 4FE7; X-ray; 2.90 A; A=1-392. DR PDBsum; 4FE4; -. DR PDBsum; 4FE7; -. DR AlphaFoldDB; P0ACI3; -. DR SMR; P0ACI3; -. DR BioGRID; 4262544; 87. DR STRING; 511145.b3569; -. DR jPOST; P0ACI3; -. DR PaxDb; 511145-b3569; -. DR EnsemblBacteria; AAC76593; AAC76593; b3569. DR GeneID; 75203010; -. DR GeneID; 948086; -. DR KEGG; ecj:JW3541; -. DR KEGG; eco:b3569; -. DR PATRIC; fig|1411691.4.peg.3143; -. DR EchoBASE; EB4154; -. DR eggNOG; COG1609; Bacteria. DR eggNOG; COG2207; Bacteria. DR HOGENOM; CLU_042405_1_0_6; -. DR InParanoid; P0ACI3; -. DR OMA; VEAAFMH; -. DR OrthoDB; 8766450at2; -. DR PhylomeDB; P0ACI3; -. DR BioCyc; EcoCyc:EG20253-MONOMER; -. DR PRO; PR:P0ACI3; -. DR Proteomes; UP000000318; Chromosome. DR Proteomes; UP000000625; Chromosome. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:EcoCyc. DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IDA:EcoCyc. DR CDD; cd01543; PBP1_XylR; 1. DR Gene3D; 3.40.50.2300; -; 2. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR018060; HTH_AraC. DR InterPro; IPR018062; HTH_AraC-typ_CS. DR InterPro; IPR046335; LacI/GalR-like_sensor. DR InterPro; IPR028082; Peripla_BP_I. DR InterPro; IPR020449; Tscrpt_reg_HTH_AraC-type. DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1. DR PANTHER; PTHR30146:SF24; XYLOSE OPERON REGULATORY PROTEIN; 1. DR Pfam; PF12833; HTH_18; 1. DR Pfam; PF13377; Peripla_BP_3; 1. DR PRINTS; PR00032; HTHARAC. DR SMART; SM00342; HTH_ARAC; 1. DR SUPFAM; SSF46689; Homeodomain-like; 2. DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1. DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1. DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1. PE 1: Evidence at protein level; KW 3D-structure; DNA-binding; Reference proteome; Transcription; KW Transcription regulation. FT CHAIN 1..392 FT /note="Xylose operon regulatory protein" FT /id="PRO_0000194597" FT DOMAIN 288..386 FT /note="HTH araC/xylS-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593" FT DNA_BIND 305..326 FT /note="H-T-H motif" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593" FT DNA_BIND 353..376 FT /note="H-T-H motif" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00593" FT STRAND 6..11 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 14..16 FT /evidence="ECO:0007829|PDB:4FE4" FT HELIX 17..33 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 37..41 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 58..63 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 67..73 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 80..85 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 90..92 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 95..101 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 103..116 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 121..125 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 134..147 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 150..152 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 155..157 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 167..180 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 185..191 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 192..205 FT /evidence="ECO:0007829|PDB:4FE7" FT TURN 209..212 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 213..219 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 224..226 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 227..230 FT /evidence="ECO:0007829|PDB:4FE4" FT STRAND 233..236 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 239..254 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 263..266 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 270..272 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 275..277 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 285..297 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 298..300 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 304..310 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 315..326 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 330..348 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 353..359 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 365..375 FT /evidence="ECO:0007829|PDB:4FE7" FT STRAND 376..378 FT /evidence="ECO:0007829|PDB:4FE7" FT HELIX 380..387 FT /evidence="ECO:0007829|PDB:4FE7" SQ SEQUENCE 392 AA; 44869 MW; AAC15819B7FC831A CRC64; MFTKRHRITL LFNANKAYDR QVVEGVGEYL QASQSEWDIF IEEDFRARID KIKDWLGDGV IADFDDKQIE QALADVDVPI VGVGGSYHLA ESYPPVHYIA TDNYALVESA FLHLKEKGVN RFAFYGLPES SGKRWATERE YAFRQLVAEE KYRGVVYQGL ETAPENWQHA QNRLADWLQT LPPQTGIIAV TDARARHILQ VCEHLHIPVP EKLCVIGIDN EELTRYLSRV ALSSVAQGAR QMGYQAAKLL HRLLDKEEMP LQRILVPPVR VIERRSTDYR SLTDPAVIQA MHYIRNHACK GIKVDQVLDA VGISRSNLEK RFKEEVGETI HAMIHAEKLE KARSLLISTT LSINEISQMC GYPSLQYFYS VFKKAYDTTP KEYRDVNSEV ML //