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Protein

Xylose operon regulatory protein

Gene

xylR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory protein for the xylBAFGHR operon.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi304 – 323H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG20253-MONOMER.
ECOL316407:JW3541-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose operon regulatory protein
Gene namesi
Name:xylR
Ordered Locus Names:b3569, JW3541
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20253. xylR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001945971 – 392Xylose operon regulatory proteinAdd BLAST392

Proteomic databases

PaxDbiP0ACI3.
PRIDEiP0ACI3.

Interactioni

Protein-protein interaction databases

BioGridi4262544. 9 interactors.
STRINGi511145.b3569.

Structurei

Secondary structure

1392
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Beta strandi14 – 16Combined sources3
Helixi17 – 33Combined sources17
Beta strandi37 – 41Combined sources5
Beta strandi58 – 63Combined sources6
Helixi67 – 73Combined sources7
Beta strandi80 – 85Combined sources6
Helixi90 – 92Combined sources3
Beta strandi95 – 101Combined sources7
Helixi103 – 116Combined sources14
Beta strandi121 – 125Combined sources5
Helixi134 – 147Combined sources14
Beta strandi150 – 152Combined sources3
Beta strandi155 – 157Combined sources3
Helixi167 – 180Combined sources14
Beta strandi185 – 191Combined sources7
Helixi192 – 205Combined sources14
Turni209 – 212Combined sources4
Beta strandi213 – 219Combined sources7
Beta strandi224 – 226Combined sources3
Beta strandi227 – 230Combined sources4
Beta strandi233 – 236Combined sources4
Helixi239 – 254Combined sources16
Beta strandi263 – 266Combined sources4
Beta strandi270 – 272Combined sources3
Helixi275 – 277Combined sources3
Helixi285 – 297Combined sources13
Helixi298 – 300Combined sources3
Helixi304 – 310Combined sources7
Helixi315 – 326Combined sources12
Helixi330 – 348Combined sources19
Helixi353 – 359Combined sources7
Helixi365 – 375Combined sources11
Beta strandi376 – 378Combined sources3
Helixi380 – 387Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FE4X-ray3.45A/B/C1-392[»]
4FE7X-ray2.90A1-392[»]
ProteinModelPortaliP0ACI3.
SMRiP0ACI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105T16. Bacteria.
ENOG410XQWR. LUCA.
HOGENOMiHOG000269135.
InParanoidiP0ACI3.
KOiK02529.
OMAiLHQMLHG.
PhylomeDBiP0ACI3.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR028082. Peripla_BP_I.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTKRHRITL LFNANKAYDR QVVEGVGEYL QASQSEWDIF IEEDFRARID
60 70 80 90 100
KIKDWLGDGV IADFDDKQIE QALADVDVPI VGVGGSYHLA ESYPPVHYIA
110 120 130 140 150
TDNYALVESA FLHLKEKGVN RFAFYGLPES SGKRWATERE YAFRQLVAEE
160 170 180 190 200
KYRGVVYQGL ETAPENWQHA QNRLADWLQT LPPQTGIIAV TDARARHILQ
210 220 230 240 250
VCEHLHIPVP EKLCVIGIDN EELTRYLSRV ALSSVAQGAR QMGYQAAKLL
260 270 280 290 300
HRLLDKEEMP LQRILVPPVR VIERRSTDYR SLTDPAVIQA MHYIRNHACK
310 320 330 340 350
GIKVDQVLDA VGISRSNLEK RFKEEVGETI HAMIHAEKLE KARSLLISTT
360 370 380 390
LSINEISQMC GYPSLQYFYS VFKKAYDTTP KEYRDVNSEV ML
Length:392
Mass (Da):44,869
Last modified:November 22, 2005 - v1
Checksum:iAAC15819B7FC831A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18546.1.
U00096 Genomic DNA. Translation: AAC76593.1.
AP009048 Genomic DNA. Translation: BAE77724.1.
PIRiS47790.
RefSeqiNP_418026.1. NC_000913.3.
WP_000494484.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76593; AAC76593; b3569.
BAE77724; BAE77724; BAE77724.
GeneIDi948086.
KEGGiecj:JW3541.
eco:b3569.
PATRICi32122614. VBIEscCol129921_3684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18546.1.
U00096 Genomic DNA. Translation: AAC76593.1.
AP009048 Genomic DNA. Translation: BAE77724.1.
PIRiS47790.
RefSeqiNP_418026.1. NC_000913.3.
WP_000494484.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FE4X-ray3.45A/B/C1-392[»]
4FE7X-ray2.90A1-392[»]
ProteinModelPortaliP0ACI3.
SMRiP0ACI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262544. 9 interactors.
STRINGi511145.b3569.

Proteomic databases

PaxDbiP0ACI3.
PRIDEiP0ACI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76593; AAC76593; b3569.
BAE77724; BAE77724; BAE77724.
GeneIDi948086.
KEGGiecj:JW3541.
eco:b3569.
PATRICi32122614. VBIEscCol129921_3684.

Organism-specific databases

EchoBASEiEB4154.
EcoGeneiEG20253. xylR.

Phylogenomic databases

eggNOGiENOG4105T16. Bacteria.
ENOG410XQWR. LUCA.
HOGENOMiHOG000269135.
InParanoidiP0ACI3.
KOiK02529.
OMAiLHQMLHG.
PhylomeDBiP0ACI3.

Enzyme and pathway databases

BioCyciEcoCyc:EG20253-MONOMER.
ECOL316407:JW3541-MONOMER.

Miscellaneous databases

PROiP0ACI3.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR028082. Peripla_BP_I.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLR_ECOLI
AccessioniPrimary (citable) accession number: P0ACI3
Secondary accession number(s): P37390, Q2M7N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.