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P0ACI3

- XYLR_ECOLI

UniProt

P0ACI3 - XYLR_ECOLI

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Protein

Xylose operon regulatory protein

Gene

xylR

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Regulatory protein for the xylBAFGHR operon.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi304 – 32320H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: EcoCyc

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: EcoCyc
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG20253-MONOMER.
ECOL316407:JW3541-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose operon regulatory protein
Gene namesi
Name:xylR
Ordered Locus Names:b3569, JW3541
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG20253. xylR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Xylose operon regulatory proteinPRO_0000194597Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP0ACI3.

Interactioni

Protein-protein interaction databases

STRINGi511145.b3569.

Structurei

Secondary structure

1
392
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 116Combined sources
Beta strandi14 – 163Combined sources
Helixi17 – 3317Combined sources
Beta strandi37 – 415Combined sources
Beta strandi58 – 636Combined sources
Helixi67 – 737Combined sources
Beta strandi80 – 856Combined sources
Helixi90 – 923Combined sources
Beta strandi95 – 1017Combined sources
Helixi103 – 11614Combined sources
Beta strandi121 – 1255Combined sources
Helixi134 – 14714Combined sources
Beta strandi150 – 1523Combined sources
Beta strandi155 – 1573Combined sources
Helixi167 – 18014Combined sources
Beta strandi185 – 1917Combined sources
Helixi192 – 20514Combined sources
Turni209 – 2124Combined sources
Beta strandi213 – 2197Combined sources
Beta strandi224 – 2263Combined sources
Beta strandi227 – 2304Combined sources
Beta strandi233 – 2364Combined sources
Helixi239 – 25416Combined sources
Beta strandi263 – 2664Combined sources
Beta strandi270 – 2723Combined sources
Helixi275 – 2773Combined sources
Helixi285 – 29713Combined sources
Helixi298 – 3003Combined sources
Helixi304 – 3107Combined sources
Helixi315 – 32612Combined sources
Helixi330 – 34819Combined sources
Helixi353 – 3597Combined sources
Helixi365 – 37511Combined sources
Beta strandi376 – 3783Combined sources
Helixi380 – 3878Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FE4X-ray3.45A/B/C1-392[»]
4FE7X-ray2.90A1-392[»]
ProteinModelPortaliP0ACI3.
SMRiP0ACI3. Positions 1-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1609.
HOGENOMiHOG000269135.
InParanoidiP0ACI3.
KOiK02529.
OMAiDWDIFIE.
OrthoDBiEOG6JHRGK.
PhylomeDBiP0ACI3.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR028082. Peripla_BP_I.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF00165. HTH_AraC. 2 hits.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFTKRHRITL LFNANKAYDR QVVEGVGEYL QASQSEWDIF IEEDFRARID
60 70 80 90 100
KIKDWLGDGV IADFDDKQIE QALADVDVPI VGVGGSYHLA ESYPPVHYIA
110 120 130 140 150
TDNYALVESA FLHLKEKGVN RFAFYGLPES SGKRWATERE YAFRQLVAEE
160 170 180 190 200
KYRGVVYQGL ETAPENWQHA QNRLADWLQT LPPQTGIIAV TDARARHILQ
210 220 230 240 250
VCEHLHIPVP EKLCVIGIDN EELTRYLSRV ALSSVAQGAR QMGYQAAKLL
260 270 280 290 300
HRLLDKEEMP LQRILVPPVR VIERRSTDYR SLTDPAVIQA MHYIRNHACK
310 320 330 340 350
GIKVDQVLDA VGISRSNLEK RFKEEVGETI HAMIHAEKLE KARSLLISTT
360 370 380 390
LSINEISQMC GYPSLQYFYS VFKKAYDTTP KEYRDVNSEV ML
Length:392
Mass (Da):44,869
Last modified:November 22, 2005 - v1
Checksum:iAAC15819B7FC831A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18546.1.
U00096 Genomic DNA. Translation: AAC76593.1.
AP009048 Genomic DNA. Translation: BAE77724.1.
PIRiS47790.
RefSeqiNP_418026.1. NC_000913.3.
YP_491865.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC76593; AAC76593; b3569.
BAE77724; BAE77724; BAE77724.
GeneIDi12933550.
948086.
KEGGiecj:Y75_p3606.
eco:b3569.
PATRICi32122614. VBIEscCol129921_3684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18546.1 .
U00096 Genomic DNA. Translation: AAC76593.1 .
AP009048 Genomic DNA. Translation: BAE77724.1 .
PIRi S47790.
RefSeqi NP_418026.1. NC_000913.3.
YP_491865.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4FE4 X-ray 3.45 A/B/C 1-392 [» ]
4FE7 X-ray 2.90 A 1-392 [» ]
ProteinModelPortali P0ACI3.
SMRi P0ACI3. Positions 1-389.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 511145.b3569.

Protein family/group databases

AraC-XylS Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC76593 ; AAC76593 ; b3569 .
BAE77724 ; BAE77724 ; BAE77724 .
GeneIDi 12933550.
948086.
KEGGi ecj:Y75_p3606.
eco:b3569.
PATRICi 32122614. VBIEscCol129921_3684.

Organism-specific databases

EchoBASEi EB4154.
EcoGenei EG20253. xylR.

Phylogenomic databases

eggNOGi COG1609.
HOGENOMi HOG000269135.
InParanoidi P0ACI3.
KOi K02529.
OMAi DWDIFIE.
OrthoDBi EOG6JHRGK.
PhylomeDBi P0ACI3.

Enzyme and pathway databases

BioCyci EcoCyc:EG20253-MONOMER.
ECOL316407:JW3541-MONOMER.

Miscellaneous databases

PROi P0ACI3.

Gene expression databases

Genevestigatori P0ACI3.

Family and domain databases

Gene3Di 1.10.10.60. 2 hits.
InterProi IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR028082. Peripla_BP_I.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view ]
Pfami PF00165. HTH_AraC. 2 hits.
[Graphical view ]
PRINTSi PR00032. HTHARAC.
SMARTi SM00342. HTH_ARAC. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
SSF53822. SSF53822. 1 hit.
PROSITEi PS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
    Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
    Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiXYLR_ECOLI
AccessioniPrimary (citable) accession number: P0ACI3
Secondary accession number(s): P37390, Q2M7N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3