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P0ACI3

- XYLR_ECOLI

UniProt

P0ACI3 - XYLR_ECOLI

Protein

Xylose operon regulatory protein

Gene

xylR

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (22 Nov 2005)
      Previous versions | rss
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    Functioni

    Regulatory protein for the xylBAFGHR operon.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi304 – 32320H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: EcoCyc

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: EcoCyc
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:EG20253-MONOMER.
    ECOL316407:JW3541-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose operon regulatory protein
    Gene namesi
    Name:xylR
    Ordered Locus Names:b3569, JW3541
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG20253. xylR.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Xylose operon regulatory proteinPRO_0000194597Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP0ACI3.

    Interactioni

    Protein-protein interaction databases

    STRINGi511145.b3569.

    Structurei

    Secondary structure

    1
    392
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 116
    Beta strandi14 – 163
    Helixi17 – 3317
    Beta strandi37 – 415
    Beta strandi58 – 636
    Helixi67 – 737
    Beta strandi80 – 856
    Helixi90 – 923
    Beta strandi95 – 1017
    Helixi103 – 11614
    Beta strandi121 – 1255
    Helixi134 – 14714
    Beta strandi150 – 1523
    Beta strandi155 – 1573
    Helixi167 – 18014
    Beta strandi185 – 1917
    Helixi192 – 20514
    Turni209 – 2124
    Beta strandi213 – 2197
    Beta strandi224 – 2263
    Beta strandi227 – 2304
    Beta strandi233 – 2364
    Helixi239 – 25416
    Beta strandi263 – 2664
    Beta strandi270 – 2723
    Helixi275 – 2773
    Helixi285 – 29713
    Helixi298 – 3003
    Helixi304 – 3107
    Helixi315 – 32612
    Helixi330 – 34819
    Helixi353 – 3597
    Helixi365 – 37511
    Beta strandi376 – 3783
    Helixi380 – 3878

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FE4X-ray3.45A/B/C1-392[»]
    4FE7X-ray2.90A1-392[»]
    ProteinModelPortaliP0ACI3.
    SMRiP0ACI3. Positions 1-389.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1609.
    HOGENOMiHOG000269135.
    KOiK02529.
    OMAiDWDIFIE.
    OrthoDBiEOG6JHRGK.
    PhylomeDBiP0ACI3.

    Family and domain databases

    Gene3Di1.10.10.60. 2 hits.
    InterProiIPR009057. Homeodomain-like.
    IPR018060. HTH_AraC.
    IPR018062. HTH_AraC-typ_CS.
    IPR028082. Peripla_BP_I.
    IPR020449. Tscrpt_reg_HTH_AraC-type.
    [Graphical view]
    PfamiPF00165. HTH_AraC. 2 hits.
    [Graphical view]
    PRINTSiPR00032. HTHARAC.
    SMARTiSM00342. HTH_ARAC. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    SSF53822. SSF53822. 1 hit.
    PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
    PS01124. HTH_ARAC_FAMILY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0ACI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTKRHRITL LFNANKAYDR QVVEGVGEYL QASQSEWDIF IEEDFRARID    50
    KIKDWLGDGV IADFDDKQIE QALADVDVPI VGVGGSYHLA ESYPPVHYIA 100
    TDNYALVESA FLHLKEKGVN RFAFYGLPES SGKRWATERE YAFRQLVAEE 150
    KYRGVVYQGL ETAPENWQHA QNRLADWLQT LPPQTGIIAV TDARARHILQ 200
    VCEHLHIPVP EKLCVIGIDN EELTRYLSRV ALSSVAQGAR QMGYQAAKLL 250
    HRLLDKEEMP LQRILVPPVR VIERRSTDYR SLTDPAVIQA MHYIRNHACK 300
    GIKVDQVLDA VGISRSNLEK RFKEEVGETI HAMIHAEKLE KARSLLISTT 350
    LSINEISQMC GYPSLQYFYS VFKKAYDTTP KEYRDVNSEV ML 392
    Length:392
    Mass (Da):44,869
    Last modified:November 22, 2005 - v1
    Checksum:iAAC15819B7FC831A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00039 Genomic DNA. Translation: AAB18546.1.
    U00096 Genomic DNA. Translation: AAC76593.1.
    AP009048 Genomic DNA. Translation: BAE77724.1.
    PIRiS47790.
    RefSeqiNP_418026.1. NC_000913.3.
    YP_491865.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC76593; AAC76593; b3569.
    BAE77724; BAE77724; BAE77724.
    GeneIDi12933550.
    948086.
    KEGGiecj:Y75_p3606.
    eco:b3569.
    PATRICi32122614. VBIEscCol129921_3684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00039 Genomic DNA. Translation: AAB18546.1 .
    U00096 Genomic DNA. Translation: AAC76593.1 .
    AP009048 Genomic DNA. Translation: BAE77724.1 .
    PIRi S47790.
    RefSeqi NP_418026.1. NC_000913.3.
    YP_491865.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FE4 X-ray 3.45 A/B/C 1-392 [» ]
    4FE7 X-ray 2.90 A 1-392 [» ]
    ProteinModelPortali P0ACI3.
    SMRi P0ACI3. Positions 1-389.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 511145.b3569.

    Protein family/group databases

    AraC-XylS Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC76593 ; AAC76593 ; b3569 .
    BAE77724 ; BAE77724 ; BAE77724 .
    GeneIDi 12933550.
    948086.
    KEGGi ecj:Y75_p3606.
    eco:b3569.
    PATRICi 32122614. VBIEscCol129921_3684.

    Organism-specific databases

    EchoBASEi EB4154.
    EcoGenei EG20253. xylR.

    Phylogenomic databases

    eggNOGi COG1609.
    HOGENOMi HOG000269135.
    KOi K02529.
    OMAi DWDIFIE.
    OrthoDBi EOG6JHRGK.
    PhylomeDBi P0ACI3.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG20253-MONOMER.
    ECOL316407:JW3541-MONOMER.

    Miscellaneous databases

    PROi P0ACI3.

    Gene expression databases

    Genevestigatori P0ACI3.

    Family and domain databases

    Gene3Di 1.10.10.60. 2 hits.
    InterProi IPR009057. Homeodomain-like.
    IPR018060. HTH_AraC.
    IPR018062. HTH_AraC-typ_CS.
    IPR028082. Peripla_BP_I.
    IPR020449. Tscrpt_reg_HTH_AraC-type.
    [Graphical view ]
    Pfami PF00165. HTH_AraC. 2 hits.
    [Graphical view ]
    PRINTSi PR00032. HTHARAC.
    SMARTi SM00342. HTH_ARAC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    SSF53822. SSF53822. 1 hit.
    PROSITEi PS00041. HTH_ARAC_FAMILY_1. 1 hit.
    PS01124. HTH_ARAC_FAMILY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
      Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
      Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

    Entry informationi

    Entry nameiXYLR_ECOLI
    AccessioniPrimary (citable) accession number: P0ACI3
    Secondary accession number(s): P37390, Q2M7N2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3