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Protein

Melibiose operon regulatory protein

Gene

melR

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi210 – 22920H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciECOL199310:C5123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Melibiose operon regulatory protein
Gene namesi
Name:melR
Ordered Locus Names:c5123
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000001410 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Melibiose operon regulatory proteinPRO_0000194538Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi199310.c5123.

Structurei

3D structure databases

ProteinModelPortaliP0ACH9.
SMRiP0ACH9. Positions 193-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108K2B. Bacteria.
ENOG410XP2B. LUCA.
HOGENOMiHOG000127063.
OMAiMCLFWGG.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
IPR008917. TF_DNA-bd.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47454. SSF47454. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTDTFMCSS DEKQTRSPLS LYSEYQRMEI EFRAPHIMPT SHWHGQVEVN
60 70 80 90 100
VPFDGDVEYL INNEKVNINQ GHITLFWACT PHQLTDTGTC QSMAIFNLPM
110 120 130 140 150
HLFLSWPLDK DLINHVTHGM VIKSLATQQL SPFEVRRWQQ ELNSPNEQIR
160 170 180 190 200
QLAIDEIGLM LKRFSLSGWE PILVNKTSRT HKNSVSRHAQ FYVSQMLGFI
210 220 230 240 250
AENYDQALTI NDVAEHVKLN ANYAMGIFQR VMQLTMKQYI TAMRINHVRA
260 270 280 290 300
LLSDTDKSIL DIALTAGFRS SSRFYSTFGK YVGMSPQQYR KLSQQRRQTF

PG
Length:302
Mass (Da):34,928
Last modified:November 22, 2005 - v1
Checksum:i2D9BC3069AB05029
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN83547.1.
RefSeqiWP_001090758.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN83547; AAN83547; c5123.
KEGGiecc:c5123.
PATRICi18287926. VBIEscCol75197_4809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014075 Genomic DNA. Translation: AAN83547.1.
RefSeqiWP_001090758.1. NC_004431.1.

3D structure databases

ProteinModelPortaliP0ACH9.
SMRiP0ACH9. Positions 193-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi199310.c5123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN83547; AAN83547; c5123.
KEGGiecc:c5123.
PATRICi18287926. VBIEscCol75197_4809.

Phylogenomic databases

eggNOGiENOG4108K2B. Bacteria.
ENOG410XP2B. LUCA.
HOGENOMiHOG000127063.
OMAiMCLFWGG.

Enzyme and pathway databases

BioCyciECOL199310:C5123-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
IPR008917. TF_DNA-bd.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47454. SSF47454. 1 hit.
SSF51182. SSF51182. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMELR_ECOL6
AccessioniPrimary (citable) accession number: P0ACH9
Secondary accession number(s): P10411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.