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Protein

Multiple antibiotic resistance protein MarA

Gene

marA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi29 – 50H-T-H motifPROSITE-ProRule annotationAdd BLAST22
DNA bindingi77 – 100H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • bacterial-type RNA polymerase core promoter sequence-specific DNA binding Source: CAFA
  • bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding Source: CAFA
  • DNA binding Source: EcoCyc
  • glyoxalase III activity Source: GO_Central
  • protein homodimerization activity Source: CAFA

GO - Biological processi

  • cellular response to menadione Source: CAFA
  • cellular response to paraquat Source: CAFA
  • methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione Source: GO_Central
  • negative regulation of transcription, DNA-templated Source: CAFA
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processAntibiotic resistance, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00365

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple antibiotic resistance protein MarA
Gene namesi
Name:marA
Ordered Locus Names:b1531, JW5249
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG11434 marA

Subcellular locationi

GO - Cellular componenti

  • protein-containing complex Source: CAFA
  • protein-DNA complex Source: CAFA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001945311 – 127Multiple antibiotic resistance protein MarAAdd BLAST127

Proteomic databases

PaxDbiP0ACH5
PRIDEiP0ACH5

Expressioni

Inductioni

By various antibiotics or by sodium salicylate.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

  • protein homodimerization activity Source: CAFA

Protein-protein interaction databases

BioGridi4259110, 129 interactors
DIPiDIP-48136N
IntActiP0ACH5, 1 interactor
STRINGi316385.ECDH10B_1662

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 19Combined sources12
Turni20 – 23Combined sources4
Helixi29 – 34Combined sources6
Beta strandi35 – 37Combined sources3
Helixi39 – 50Combined sources12
Helixi54 – 72Combined sources19
Helixi77 – 83Combined sources7
Helixi89 – 100Combined sources12
Helixi104 – 108Combined sources5
Beta strandi115 – 117Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BL0X-ray2.30A1-127[»]
1XS9NMR-A1-127[»]
ProteinModelPortaliP0ACH5
SMRiP0ACH5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACH5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 110HTH araC/xylS-typePROSITE-ProRule annotationAdd BLAST99

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108XW0 Bacteria
ENOG4111IUP LUCA
HOGENOMiHOG000120762
InParanoidiP0ACH5
KOiK13632
OMAiATFTRIF
PhylomeDBiP0ACH5

Family and domain databases

InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR018060 HTH_AraC
IPR018062 HTH_AraC-typ_CS
PfamiView protein in Pfam
PF12833 HTH_18, 1 hit
SMARTiView protein in SMART
SM00342 HTH_ARAC, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00041 HTH_ARAC_FAMILY_1, 1 hit
PS01124 HTH_ARAC_FAMILY_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRNTDAIT IHSILDWIED NLESPLSLEK VSERSGYSKW HLQRMFKKET
60 70 80 90 100
GHSLGQYIRS RKMTEIAQKL KESNEPILYL AERYGFESQQ TLTRTFKNYF
110 120
DVPPHKYRMT NMQGESRFLH PLNHYNS
Length:127
Mass (Da):15,184
Last modified:November 13, 2007 - v2
Checksum:iA547C8F1553A9196
GO

Sequence cautioni

The sequence AAC16395 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96235 Genomic DNA Translation: AAC16395.1 Different initiation.
L06966 Genomic DNA Translation: AAA24113.1
U00096 Genomic DNA Translation: AAC74604.2
AP009048 Genomic DNA Translation: BAA15221.2
PIRiB47072
RefSeqiNP_416048.2, NC_000913.3
WP_000091199.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74604; AAC74604; b1531
BAA15221; BAA15221; BAA15221
GeneIDi947613
KEGGiecj:JW5249
eco:b1531
PATRICifig|1411691.4.peg.735

Entry informationi

Entry nameiMARA_ECOLI
AccessioniPrimary (citable) accession number: P0ACH5
Secondary accession number(s): P27246
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 13, 2007
Last modified: April 25, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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