Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multiple antibiotic resistance protein MarA

Gene

marA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi29 – 50H-T-H motifPROSITE-ProRule annotationAdd BLAST22
DNA bindingi77 – 100H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Antibiotic resistance, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00365.
ECOL316407:JW5249-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple antibiotic resistance protein MarA
Gene namesi
Name:marA
Ordered Locus Names:b1531, JW5249
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11434. marA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001945311 – 127Multiple antibiotic resistance protein MarAAdd BLAST127

Proteomic databases

PaxDbiP0ACH5.
PRIDEiP0ACH5.

Expressioni

Inductioni

By various antibiotics or by sodium salicylate.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi4259110. 129 interactors.
DIPiDIP-48136N.
IntActiP0ACH5. 1 interactor.
MINTiMINT-1251059.
STRINGi511145.b1531.

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 19Combined sources12
Turni20 – 23Combined sources4
Helixi29 – 34Combined sources6
Beta strandi35 – 37Combined sources3
Helixi39 – 50Combined sources12
Helixi54 – 72Combined sources19
Helixi77 – 83Combined sources7
Helixi89 – 100Combined sources12
Helixi104 – 108Combined sources5
Beta strandi115 – 117Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BL0X-ray2.30A1-127[»]
1XS9NMR-A1-127[»]
ProteinModelPortaliP0ACH5.
SMRiP0ACH5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACH5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 110HTH araC/xylS-typePROSITE-ProRule annotationAdd BLAST99

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108XW0. Bacteria.
ENOG4111IUP. LUCA.
HOGENOMiHOG000120762.
InParanoidiP0ACH5.
KOiK13632.
OMAiATFTRIF.
PhylomeDBiP0ACH5.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRNTDAIT IHSILDWIED NLESPLSLEK VSERSGYSKW HLQRMFKKET
60 70 80 90 100
GHSLGQYIRS RKMTEIAQKL KESNEPILYL AERYGFESQQ TLTRTFKNYF
110 120
DVPPHKYRMT NMQGESRFLH PLNHYNS
Length:127
Mass (Da):15,184
Last modified:November 13, 2007 - v2
Checksum:iA547C8F1553A9196
GO

Sequence cautioni

The sequence AAC16395 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96235 Genomic DNA. Translation: AAC16395.1. Different initiation.
L06966 Genomic DNA. Translation: AAA24113.1.
U00096 Genomic DNA. Translation: AAC74604.2.
AP009048 Genomic DNA. Translation: BAA15221.2.
PIRiB47072.
RefSeqiNP_416048.2. NC_000913.3.
WP_000091199.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74604; AAC74604; b1531.
BAA15221; BAA15221; BAA15221.
GeneIDi947613.
KEGGiecj:JW5249.
eco:b1531.
PATRICi32118360. VBIEscCol129921_1600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96235 Genomic DNA. Translation: AAC16395.1. Different initiation.
L06966 Genomic DNA. Translation: AAA24113.1.
U00096 Genomic DNA. Translation: AAC74604.2.
AP009048 Genomic DNA. Translation: BAA15221.2.
PIRiB47072.
RefSeqiNP_416048.2. NC_000913.3.
WP_000091199.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BL0X-ray2.30A1-127[»]
1XS9NMR-A1-127[»]
ProteinModelPortaliP0ACH5.
SMRiP0ACH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259110. 129 interactors.
DIPiDIP-48136N.
IntActiP0ACH5. 1 interactor.
MINTiMINT-1251059.
STRINGi511145.b1531.

Proteomic databases

PaxDbiP0ACH5.
PRIDEiP0ACH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74604; AAC74604; b1531.
BAA15221; BAA15221; BAA15221.
GeneIDi947613.
KEGGiecj:JW5249.
eco:b1531.
PATRICi32118360. VBIEscCol129921_1600.

Organism-specific databases

EchoBASEiEB1404.
EcoGeneiEG11434. marA.

Phylogenomic databases

eggNOGiENOG4108XW0. Bacteria.
ENOG4111IUP. LUCA.
HOGENOMiHOG000120762.
InParanoidiP0ACH5.
KOiK13632.
OMAiATFTRIF.
PhylomeDBiP0ACH5.

Enzyme and pathway databases

BioCyciEcoCyc:PD00365.
ECOL316407:JW5249-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ACH5.
PROiP0ACH5.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
[Graphical view]
PfamiPF12833. HTH_18. 1 hit.
[Graphical view]
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMARA_ECOLI
AccessioniPrimary (citable) accession number: P0ACH5
Secondary accession number(s): P27246
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.