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Protein

Heat shock protein 15

Gene

hslR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the recycling of free 50S ribosomal subunits that still carry a nascent chain. Binds RNA more specifically than DNA. Binds with very high affinity to the free 50S ribosomal subunit. Does not bind it when it is part of the 70S ribosome.

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • ribosomal large subunit binding Source: EcoCyc
  • single-stranded RNA binding Source: EcoCyc

GO - Biological processi

  • cellular response to heat Source: EcoCyc
  • response to heat Source: EcoliWiki
  • RNA modification Source: GO_Central

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processStress response

Enzyme and pathway databases

BioCyciEcoCyc:G7743-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 15
Short name:
HSP15
Gene namesi
Name:hslR
Synonyms:yrfH
Ordered Locus Names:b3400, JW3363
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12929 hslR

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002017411 – 133Heat shock protein 15Add BLAST133

Proteomic databases

PaxDbiP0ACG8
PRIDEiP0ACG8

Expressioni

Inductioni

By heat shock.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4260979, 268 interactors
DIPiDIP-48014N
IntActiP0ACG8, 37 interactors
STRINGi316385.ECDH10B_3575

Structurei

Secondary structure

1133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 17Combined sources7
Beta strandi20 – 23Combined sources4
Helixi24 – 32Combined sources9
Beta strandi36 – 38Combined sources3
Beta strandi54 – 59Combined sources6
Beta strandi62 – 68Combined sources7
Beta strandi70 – 73Combined sources4
Helixi78 – 81Combined sources4
Helixi82 – 84Combined sources3
Beta strandi85 – 87Combined sources3
Helixi89 – 106Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DM9X-ray2.00A/B1-133[»]
3BBUelectron microscopy10.00A5-108[»]
ProteinModelPortaliP0ACG8
SMRiP0ACG8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ACG8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 71S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the HSP15 family.Curated

Phylogenomic databases

eggNOGiENOG4105VEJ Bacteria
COG1188 LUCA
HOGENOMiHOG000216822
InParanoidiP0ACG8
KOiK04762
OMAiRFYKTRT
PhylomeDBiP0ACG8

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di3.10.290.10, 1 hit
InterProiView protein in InterPro
IPR025708 HSP15
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
PfamiView protein in Pfam
PF01479 S4, 1 hit
PIRSFiPIRSF016821 HSP15, 1 hit
SMARTiView protein in SMART
SM00363 S4, 1 hit
PROSITEiView protein in PROSITE
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKPAVEVR LDKWLWAARF YKTRALAREM IEGGKVHYNG QRSKPSKIVE
60 70 80 90 100
LNATLTLRQG NDERTVIVKA ITEQRRPASE AALLYEETAE SVEKREKMAL
110 120 130
ARKLNALTMP HPDRRPDKKE RRDLLRFKHG DSE
Length:133
Mass (Da):15,496
Last modified:November 22, 2005 - v1
Checksum:i4B3D40FAECC42D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58197.1
U00096 Genomic DNA Translation: AAC76425.1
AP009048 Genomic DNA Translation: BAE77891.1
PIRiC65135
RefSeqiNP_417859.1, NC_000913.3
WP_000660483.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76425; AAC76425; b3400
BAE77891; BAE77891; BAE77891
GeneIDi947912
KEGGiecj:JW3363
eco:b3400
PATRICifig|1411691.4.peg.3330

Similar proteinsi

Entry informationi

Entry nameiHSLR_ECOLI
AccessioniPrimary (citable) accession number: P0ACG8
Secondary accession number(s): P45802, Q2M765
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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