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Protein

Protein HokD

Gene

hokD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

When overexpressed kills the cells from the inside by interfering with a vital function in the cell membrane.
Overexpression of relF results in collapse of the transmembrane potential and concomitant arrest of oxygen consumption.

Enzyme and pathway databases

BioCyciEcoCyc:EG11130-MONOMER.
ECOL316407:JW1554-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HokD
Alternative name(s):
Protein RelF
Gene namesi
Name:hokD
Synonyms:relF
Ordered Locus Names:b1562, JW1554
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11130. hokD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5151Protein HokDPRO_0000199033Add
BLAST

Proteomic databases

PaxDbiP0ACG6.

Interactioni

Protein-protein interaction databases

BioGridi4260242. 117 interactions.
STRINGi511145.b1562.

Structurei

3D structure databases

ProteinModelPortaliP0ACG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hok/gef family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000041219.
KOiK18919.
OMAiCEVRIRS.
PhylomeDBiP0ACG6.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQQKAMLIA LIVICLTVIV TALVTRKDLC EVRIRTGQTE VAVFTAYEPE

E
Length:51
Mass (Da):5,737
Last modified:November 22, 2005 - v1
Checksum:i927EDBDE60B61A27
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371G → D in CAA26252 (PubMed:2990907).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02405 Genomic DNA. Translation: CAA26252.1.
U00096 Genomic DNA. Translation: AAC74635.1.
AP009048 Genomic DNA. Translation: BAA15261.1.
PIRiE64911. QQECR5.
RefSeqiNP_416080.1. NC_000913.3.
WP_000813254.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74635; AAC74635; b1562.
BAA15261; BAA15261; BAA15261.
GeneIDi948616.
KEGGiecj:JW1554.
eco:b1562.
PATRICi32118430. VBIEscCol129921_1635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02405 Genomic DNA. Translation: CAA26252.1.
U00096 Genomic DNA. Translation: AAC74635.1.
AP009048 Genomic DNA. Translation: BAA15261.1.
PIRiE64911. QQECR5.
RefSeqiNP_416080.1. NC_000913.3.
WP_000813254.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260242. 117 interactions.
STRINGi511145.b1562.

Proteomic databases

PaxDbiP0ACG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74635; AAC74635; b1562.
BAA15261; BAA15261; BAA15261.
GeneIDi948616.
KEGGiecj:JW1554.
eco:b1562.
PATRICi32118430. VBIEscCol129921_1635.

Organism-specific databases

EchoBASEiEB1120.
EcoGeneiEG11130. hokD.

Phylogenomic databases

HOGENOMiHOG000041219.
KOiK18919.
OMAiCEVRIRS.
PhylomeDBiP0ACG6.

Enzyme and pathway databases

BioCyciEcoCyc:EG11130-MONOMER.
ECOL316407:JW1554-MONOMER.

Miscellaneous databases

PROiP0ACG6.

Family and domain databases

InterProiIPR000021. Hok/gef_toxin.
IPR018084. Hok/gef_toxin_CS.
[Graphical view]
PfamiPF01848. HOK_GEF. 1 hit.
[Graphical view]
PRINTSiPR00281. HOKGEFTOXIC.
ProDomiPD005979. Hok/gef_toxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00556. HOK_GEF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHOKD_ECOLI
AccessioniPrimary (citable) accession number: P0ACG6
Secondary accession number(s): P07009, P77643, Q8X294
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 22, 2005
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.