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Protein

Toxic protein HokD

Gene

hokD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within 2 minutes; causes collapse of the transmembrane potential and arrest of respiration (PubMed:3019679).By similarity1 Publication

Miscellaneous

Probably inactive in strain K12 MG1655 due to a genetic locus rearrangement, the locus for its antisense antitoxin RNA is missing.1 Publication

Keywordsi

Biological processToxin-antitoxin system

Enzyme and pathway databases

BioCyciEcoCyc:EG11130-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Toxic protein HokD
Alternative name(s):
Protein RelF
Gene namesi
Name:hokD1 Publication
Synonyms:relF
Ordered Locus Names:b1562, JW1554
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11130 hokD

Subcellular locationi

  • Cell inner membrane By similarity1 Publication; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001990331 – 51Toxic protein HokDAdd BLAST51

Proteomic databases

PaxDbiP0ACG6
PRIDEiP0ACG6

Interactioni

Protein-protein interaction databases

BioGridi4260242, 117 interactors
STRINGi316385.ECDH10B_1694

Structurei

3D structure databases

ProteinModelPortaliP0ACG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Hok/Gef family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000041219
KOiK18919
OMAiCEVRIRS
PhylomeDBiP0ACG6

Family and domain databases

InterProiView protein in InterPro
IPR000021 Hok/gef_toxin
IPR018084 Hok/gef_toxin_CS
PfamiView protein in Pfam
PF01848 HOK_GEF, 1 hit
PRINTSiPR00281 HOKGEFTOXIC
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005979 Hok/gef_toxin, 1 hit
PROSITEiView protein in PROSITE
PS00556 HOK_GEF, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQQKAMLIA LIVICLTVIV TALVTRKDLC EVRIRTGQTE VAVFTAYEPE

E
Length:51
Mass (Da):5,737
Last modified:November 22, 2005 - v1
Checksum:i927EDBDE60B61A27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37G → D in CAA26252 (PubMed:2990907).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02405 Genomic DNA Translation: CAA26252.1
U00096 Genomic DNA Translation: AAC74635.1
AP009048 Genomic DNA Translation: BAA15261.1
PIRiE64911 QQECR5
RefSeqiNP_416080.1, NC_000913.3
WP_000813254.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74635; AAC74635; b1562
BAA15261; BAA15261; BAA15261
GeneIDi948616
KEGGiecj:JW1554
eco:b1562
PATRICifig|1411691.4.peg.700

Similar proteinsi

Entry informationi

Entry nameiHOKD_ECOLI
AccessioniPrimary (citable) accession number: P0ACG6
Secondary accession number(s): P07009, P77643, Q8X294
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: November 22, 2005
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health