P0ACG1 (STPA_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-binding protein StpA

Alternative name(s):
H-NS homolog StpA

Gene names

Name:	stpA
Synonyms:	hnsB
Ordered Locus Names:	b2669, JW2644

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	It may act in a fashion similar to H-NS proteins.
Sequence similarities	Belongs to the histone-like protein H-NS family.

Ontologies

Keywords
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from direct assay PubMed 10551881. Source: EcoliWiki
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 134	134	DNA-binding protein StpA		PRO_0000168513
Regions
	Compositional bias	42 – 45	4	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	P0ACG1 [UniParc]. Last modified November 22, 2005. Version 1. Checksum: 5870BD95F144CE6A	FASTA	134	15,348
	10 20 30 40 50 60 MSVMLQSLNN IRTLRAMARE FSIDVLEEML EKFRVVTKER REEEEQQQRE LAERQEKIST 70 80 90 100 110 120 WLELMKADGI NPEELLGNSS AAAPRAGKKR QPRPAKYKFT DVNGETKTWT GQGRTPKPIA 130 QALAEGKSLD DFLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of a newly-identified Escherichia coli gene, stpA, encoding an H-NS-like protein." Zhang A., Belfort M. Nucleic Acids Res. 20:6735-6735(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Plasmids bearing hfq and the hns-like gene stpA complement hns mutants in modulating arginine decarboxylase gene expression in Escherichia coli." Shi X., Bennett G.N. J. Bacteriol. 176:6769-6775(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[3]	"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T. DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[5]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]	"Coordinated and differential expression of histone-like proteins in Escherichia coli: regulation and function of the H-NS analog StpA." Sonden B., Uhlin B.E. EMBO J. 15:4970-4980(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21. Strain: K12.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69210 Genomic DNA. Translation: CAA49146.1. U07823 Genomic DNA. Translation: AAA64940.1. U00096 Genomic DNA. Translation: AAC75716.1. AP009048 Genomic DNA. Translation: BAA16535.1.
PIR	JH0774.
RefSeq	NP_417155.1. NC_000913.2. YP_490884.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0ACG1.
SMR	P0ACG1. Positions 2-82, 93-134.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-35951N.
IntAct	P0ACG1. 22 interactions.
MINT	MINT-1247857.
STRING	511145.b2669.
Proteomic databases
PaxDb	P0ACG1.
PRIDE	P0ACG1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75716; AAC75716; b2669. BAA16535; BAA16535; BAA16535.
GeneID	12933267. 947130.
KEGG	ecj:Y75_p2612. eco:b2669.
PATRIC	32120728. VBIEscCol129921_2761.
Organism-specific databases
EchoBASE	EB1515.
EcoGene	EG11554. stpA.
Phylogenomic databases
eggNOG	COG2916.
HOGENOM	HOG000218473.
KO	K11685.
OMA	NTWLELM.
ProtClustDB	PRK10328.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11554-MONOMER. ECOL316407:JW2644-MONOMER.
Gene expression databases
Genevestigator	P0ACG1.
Family and domain databases
InterPro	IPR001801. Histone_HNS. [Graphical view]
Pfam	PF00816. Histone_HNS. 1 hit. [Graphical view]
PIRSF	PIRSF002096. HnS. 1 hit.
SMART	SM00528. HNS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

STPA_ECOLI

Accession

Primary (citable) accession number: P0ACG1
Secondary accession number(s): P30017

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 22, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program