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Protein

DNA-binding protein StpA

Gene

stpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

It may act in a fashion similar to H-NS proteins.

GO - Molecular functioni

  1. DNA binding Source: EcoliWiki

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11554-MONOMER.
ECOL316407:JW2644-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein StpA
Alternative name(s):
H-NS homolog StpA
Gene namesi
Name:stpA
Synonyms:hnsB
Ordered Locus Names:b2669, JW2644
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11554. stpA.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 134134DNA-binding protein StpAPRO_0000168513Add
BLAST

Proteomic databases

PaxDbiP0ACG1.
PRIDEiP0ACG1.

Expressioni

Gene expression databases

GenevestigatoriP0ACG1.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hnsP0ACF83EBI-551928,EBI-544934

Protein-protein interaction databases

DIPiDIP-35951N.
IntActiP0ACG1. 23 interactions.
MINTiMINT-1247857.
STRINGi511145.b2669.

Structurei

Secondary structure

1
134
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi117 – 1248Combined sources
Helixi129 – 1313Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LRXNMR-A90-134[»]
ProteinModelPortaliP0ACG1.
SMRiP0ACG1. Positions 2-82, 90-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 454Poly-Glu

Sequence similaritiesi

Belongs to the histone-like protein H-NS family.Curated

Phylogenomic databases

eggNOGiCOG2916.
HOGENOMiHOG000218473.
KOiK11685.
OMAiVNTWLEL.
OrthoDBiEOG6NPM97.

Family and domain databases

Gene3Di1.10.287.1050. 1 hit.
4.10.430.10. 1 hit.
InterProiIPR027444. H-NS_C_dom.
IPR001801. Histone_HNS.
IPR027454. Histone_HNS_oligo_dom.
[Graphical view]
PfamiPF00816. Histone_HNS. 1 hit.
[Graphical view]
PIRSFiPIRSF002096. HnS. 1 hit.
SMARTiSM00528. HNS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMLQSLNN IRTLRAMARE FSIDVLEEML EKFRVVTKER REEEEQQQRE
60 70 80 90 100
LAERQEKIST WLELMKADGI NPEELLGNSS AAAPRAGKKR QPRPAKYKFT
110 120 130
DVNGETKTWT GQGRTPKPIA QALAEGKSLD DFLI
Length:134
Mass (Da):15,348
Last modified:November 22, 2005 - v1
Checksum:i5870BD95F144CE6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69210 Genomic DNA. Translation: CAA49146.1.
U07823 Genomic DNA. Translation: AAA64940.1.
U00096 Genomic DNA. Translation: AAC75716.1.
AP009048 Genomic DNA. Translation: BAA16535.1.
PIRiJH0774.
RefSeqiNP_417155.1. NC_000913.3.
YP_490884.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75716; AAC75716; b2669.
BAA16535; BAA16535; BAA16535.
GeneIDi12933267.
947130.
KEGGiecj:Y75_p2612.
eco:b2669.
PATRICi32120728. VBIEscCol129921_2761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69210 Genomic DNA. Translation: CAA49146.1.
U07823 Genomic DNA. Translation: AAA64940.1.
U00096 Genomic DNA. Translation: AAC75716.1.
AP009048 Genomic DNA. Translation: BAA16535.1.
PIRiJH0774.
RefSeqiNP_417155.1. NC_000913.3.
YP_490884.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LRXNMR-A90-134[»]
ProteinModelPortaliP0ACG1.
SMRiP0ACG1. Positions 2-82, 90-134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35951N.
IntActiP0ACG1. 23 interactions.
MINTiMINT-1247857.
STRINGi511145.b2669.

Proteomic databases

PaxDbiP0ACG1.
PRIDEiP0ACG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75716; AAC75716; b2669.
BAA16535; BAA16535; BAA16535.
GeneIDi12933267.
947130.
KEGGiecj:Y75_p2612.
eco:b2669.
PATRICi32120728. VBIEscCol129921_2761.

Organism-specific databases

EchoBASEiEB1515.
EcoGeneiEG11554. stpA.

Phylogenomic databases

eggNOGiCOG2916.
HOGENOMiHOG000218473.
KOiK11685.
OMAiVNTWLEL.
OrthoDBiEOG6NPM97.

Enzyme and pathway databases

BioCyciEcoCyc:EG11554-MONOMER.
ECOL316407:JW2644-MONOMER.

Miscellaneous databases

PROiP0ACG1.

Gene expression databases

GenevestigatoriP0ACG1.

Family and domain databases

Gene3Di1.10.287.1050. 1 hit.
4.10.430.10. 1 hit.
InterProiIPR027444. H-NS_C_dom.
IPR001801. Histone_HNS.
IPR027454. Histone_HNS_oligo_dom.
[Graphical view]
PfamiPF00816. Histone_HNS. 1 hit.
[Graphical view]
PIRSFiPIRSF002096. HnS. 1 hit.
SMARTiSM00528. HNS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a newly-identified Escherichia coli gene, stpA, encoding an H-NS-like protein."
    Zhang A., Belfort M.
    Nucleic Acids Res. 20:6735-6735(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Plasmids bearing hfq and the hns-like gene stpA complement hns mutants in modulating arginine decarboxylase gene expression in Escherichia coli."
    Shi X., Bennett G.N.
    J. Bacteriol. 176:6769-6775(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  3. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Coordinated and differential expression of histone-like proteins in Escherichia coli: regulation and function of the H-NS analog StpA."
    Sonden B., Uhlin B.E.
    EMBO J. 15:4970-4980(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
    Strain: K12.

Entry informationi

Entry nameiSTPA_ECOLI
AccessioniPrimary (citable) accession number: P0ACG1
Secondary accession number(s): P30017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: January 7, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.