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P0ACG1

- STPA_ECOLI

UniProt

P0ACG1 - STPA_ECOLI

Protein

DNA-binding protein StpA

Gene

stpA

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    It may act in a fashion similar to H-NS proteins.

    GO - Molecular functioni

    1. DNA binding Source: EcoliWiki
    2. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciEcoCyc:EG11554-MONOMER.
    ECOL316407:JW2644-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-binding protein StpA
    Alternative name(s):
    H-NS homolog StpA
    Gene namesi
    Name:stpA
    Synonyms:hnsB
    Ordered Locus Names:b2669, JW2644
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11554. stpA.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 134134DNA-binding protein StpAPRO_0000168513Add
    BLAST

    Proteomic databases

    PaxDbiP0ACG1.
    PRIDEiP0ACG1.

    Expressioni

    Gene expression databases

    GenevestigatoriP0ACG1.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    hnsP0ACF83EBI-551928,EBI-544934

    Protein-protein interaction databases

    DIPiDIP-35951N.
    IntActiP0ACG1. 23 interactions.
    MINTiMINT-1247857.
    STRINGi511145.b2669.

    Structurei

    Secondary structure

    1
    134
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi117 – 1248
    Helixi129 – 1313

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LRXNMR-A90-134[»]
    ProteinModelPortaliP0ACG1.
    SMRiP0ACG1. Positions 2-82, 90-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi42 – 454Poly-Glu

    Sequence similaritiesi

    Belongs to the histone-like protein H-NS family.Curated

    Phylogenomic databases

    eggNOGiCOG2916.
    HOGENOMiHOG000218473.
    KOiK11685.
    OMAiVNTWLEL.
    OrthoDBiEOG6NPM97.

    Family and domain databases

    Gene3Di1.10.287.1050. 1 hit.
    4.10.430.10. 1 hit.
    InterProiIPR027444. H-NS_C_dom.
    IPR001801. Histone_HNS.
    IPR027454. Histone_HNS_oligo_dom.
    [Graphical view]
    PfamiPF00816. Histone_HNS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002096. HnS. 1 hit.
    SMARTiSM00528. HNS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0ACG1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVMLQSLNN IRTLRAMARE FSIDVLEEML EKFRVVTKER REEEEQQQRE    50
    LAERQEKIST WLELMKADGI NPEELLGNSS AAAPRAGKKR QPRPAKYKFT 100
    DVNGETKTWT GQGRTPKPIA QALAEGKSLD DFLI 134
    Length:134
    Mass (Da):15,348
    Last modified:November 22, 2005 - v1
    Checksum:i5870BD95F144CE6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69210 Genomic DNA. Translation: CAA49146.1.
    U07823 Genomic DNA. Translation: AAA64940.1.
    U00096 Genomic DNA. Translation: AAC75716.1.
    AP009048 Genomic DNA. Translation: BAA16535.1.
    PIRiJH0774.
    RefSeqiNP_417155.1. NC_000913.3.
    YP_490884.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC75716; AAC75716; b2669.
    BAA16535; BAA16535; BAA16535.
    GeneIDi12933267.
    947130.
    KEGGiecj:Y75_p2612.
    eco:b2669.
    PATRICi32120728. VBIEscCol129921_2761.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69210 Genomic DNA. Translation: CAA49146.1 .
    U07823 Genomic DNA. Translation: AAA64940.1 .
    U00096 Genomic DNA. Translation: AAC75716.1 .
    AP009048 Genomic DNA. Translation: BAA16535.1 .
    PIRi JH0774.
    RefSeqi NP_417155.1. NC_000913.3.
    YP_490884.1. NC_007779.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LRX NMR - A 90-134 [» ]
    ProteinModelPortali P0ACG1.
    SMRi P0ACG1. Positions 2-82, 90-134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-35951N.
    IntActi P0ACG1. 23 interactions.
    MINTi MINT-1247857.
    STRINGi 511145.b2669.

    Proteomic databases

    PaxDbi P0ACG1.
    PRIDEi P0ACG1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC75716 ; AAC75716 ; b2669 .
    BAA16535 ; BAA16535 ; BAA16535 .
    GeneIDi 12933267.
    947130.
    KEGGi ecj:Y75_p2612.
    eco:b2669.
    PATRICi 32120728. VBIEscCol129921_2761.

    Organism-specific databases

    EchoBASEi EB1515.
    EcoGenei EG11554. stpA.

    Phylogenomic databases

    eggNOGi COG2916.
    HOGENOMi HOG000218473.
    KOi K11685.
    OMAi VNTWLEL.
    OrthoDBi EOG6NPM97.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG11554-MONOMER.
    ECOL316407:JW2644-MONOMER.

    Miscellaneous databases

    PROi P0ACG1.

    Gene expression databases

    Genevestigatori P0ACG1.

    Family and domain databases

    Gene3Di 1.10.287.1050. 1 hit.
    4.10.430.10. 1 hit.
    InterProi IPR027444. H-NS_C_dom.
    IPR001801. Histone_HNS.
    IPR027454. Histone_HNS_oligo_dom.
    [Graphical view ]
    Pfami PF00816. Histone_HNS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002096. HnS. 1 hit.
    SMARTi SM00528. HNS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a newly-identified Escherichia coli gene, stpA, encoding an H-NS-like protein."
      Zhang A., Belfort M.
      Nucleic Acids Res. 20:6735-6735(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. "Plasmids bearing hfq and the hns-like gene stpA complement hns mutants in modulating arginine decarboxylase gene expression in Escherichia coli."
      Shi X., Bennett G.N.
      J. Bacteriol. 176:6769-6775(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    3. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
      Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
      , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
      DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    6. "Coordinated and differential expression of histone-like proteins in Escherichia coli: regulation and function of the H-NS analog StpA."
      Sonden B., Uhlin B.E.
      EMBO J. 15:4970-4980(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
      Strain: K12.

    Entry informationi

    Entry nameiSTPA_ECOLI
    AccessioniPrimary (citable) accession number: P0ACG1
    Secondary accession number(s): P30017
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 22, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3