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Protein

DNA-binding protein HU-alpha

Gene

hupA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA condensation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4923-MONOMER.
ECOO157:HUPA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein HU-alpha
Alternative name(s):
HU-2
NS2
Gene namesi
Name:hupA
Ordered Locus Names:Z5576, ECs4923
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9090DNA-binding protein HU-alphaPRO_0000104936Add
BLAST

Proteomic databases

PRIDEiP0ACF2.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Protein-protein interaction databases

MINTiMINT-1244389.
STRINGi155864.Z5576.

Structurei

3D structure databases

ProteinModelPortaliP0ACF2.
SMRiP0ACF2. Positions 1-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105K70. Bacteria.
COG0776. LUCA.
HOGENOMiHOG000043828.
KOiK05787.
OMAiMNSITYE.
OrthoDBiEOG615VS6.

Family and domain databases

Gene3Di4.10.520.10. 1 hit.
InterProiIPR000119. Hist_DNA-bd.
IPR020816. Histone-like_DNA-bd_CS.
IPR010992. IHF-like_DNA-bd_dom.
[Graphical view]
PfamiPF00216. Bac_DNA_binding. 1 hit.
[Graphical view]
PRINTSiPR01727. DNABINDINGHU.
SMARTiSM00411. BHL. 1 hit.
[Graphical view]
SUPFAMiSSF47729. SSF47729. 1 hit.
PROSITEiPS00045. HISTONE_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKTQLIDVI AEKAELSKTQ AKAALESTLA AITESLKEGD AVQLVGFGTF
60 70 80 90
KVNHRAERTG RNPQTGKEIK IAAANVPAFV SGKALKDAVK
Length:90
Mass (Da):9,535
Last modified:July 21, 1986 - v1
Checksum:i6B5B8536FDBD13DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59197.1.
BA000007 Genomic DNA. Translation: BAB38346.1.
PIRiA86092.
C91244.
RefSeqiNP_312950.1. NC_002695.1.
WP_001044513.1. NZ_LPWC01000213.1.

Genome annotation databases

EnsemblBacteriaiAAG59197; AAG59197; Z5576.
BAB38346; BAB38346; BAB38346.
GeneIDi914933.
KEGGiece:Z5576.
ecs:ECs4923.
PATRICi18359539. VBIEscCol44059_4910.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59197.1.
BA000007 Genomic DNA. Translation: BAB38346.1.
PIRiA86092.
C91244.
RefSeqiNP_312950.1. NC_002695.1.
WP_001044513.1. NZ_LPWC01000213.1.

3D structure databases

ProteinModelPortaliP0ACF2.
SMRiP0ACF2. Positions 1-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1244389.
STRINGi155864.Z5576.

Proteomic databases

PRIDEiP0ACF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG59197; AAG59197; Z5576.
BAB38346; BAB38346; BAB38346.
GeneIDi914933.
KEGGiece:Z5576.
ecs:ECs4923.
PATRICi18359539. VBIEscCol44059_4910.

Phylogenomic databases

eggNOGiENOG4105K70. Bacteria.
COG0776. LUCA.
HOGENOMiHOG000043828.
KOiK05787.
OMAiMNSITYE.
OrthoDBiEOG615VS6.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4923-MONOMER.
ECOO157:HUPA-MONOMER.

Family and domain databases

Gene3Di4.10.520.10. 1 hit.
InterProiIPR000119. Hist_DNA-bd.
IPR020816. Histone-like_DNA-bd_CS.
IPR010992. IHF-like_DNA-bd_dom.
[Graphical view]
PfamiPF00216. Bac_DNA_binding. 1 hit.
[Graphical view]
PRINTSiPR01727. DNABINDINGHU.
SMARTiSM00411. BHL. 1 hit.
[Graphical view]
SUPFAMiSSF47729. SSF47729. 1 hit.
PROSITEiPS00045. HISTONE_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiDBHA_ECO57
AccessioniPrimary (citable) accession number: P0ACF2
Secondary accession number(s): P02342
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.