P0ACF2 (DBHA_ECO57) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-binding protein HU-alpha

Alternative name(s):
HU-2
NS2

Gene names

Name:	hupA
Ordered Locus Names:	Z5576, ECs4923

Organism

Escherichia coli O157:H7 [Complete proteome] [HAMAP]

Taxonomic identifier

83334 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions By similarity.
Subunit structure	Heterodimer of an alpha and a beta chain By similarity.
Sequence similarities	Belongs to the bacterial histone-like protein family.

Ontologies

Keywords
Biological process	DNA condensation
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chromosome condensation Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 90	90	DNA-binding protein HU-alpha		PRO_0000104936

Sequences

	Sequence		Length	Mass (Da)
	P0ACF2 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 6B5B8536FDBD13DC	FASTA	90	9,535
	10 20 30 40 50 60 MNKTQLIDVI AEKAELSKTQ AKAALESTLA AITESLKEGD AVQLVGFGTF KVNHRAERTG 70 80 90 RNPQTGKEIK IAAANVPAFV SGKALKDAVK

References

[1]	"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R. Nature 409:529-533(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
[2]	"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. , Kuhara S., Shiba T., Hattori M., Shinagawa H. DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005174 Genomic DNA. Translation: AAG59197.1. BA000007 Genomic DNA. Translation: BAB38346.1.
PIR	A86092. C91244.
RefSeq	NP_290632.1. NC_002655.2. NP_312950.1. NC_002695.1.
3D structure databases
ProteinModelPortal	P0ACF2.
SMR	P0ACF2. Positions 1-90.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1244389.
STRING	155864.Z5576.
Proteomic databases
PRIDE	P0ACF2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAG59197; AAG59197; Z5576. BAB38346; BAB38346; BAB38346.
GeneID	914933. 960129.
KEGG	ece:Z5576. ecs:ECs4923.
PATRIC	18359539. VBIEscCol44059_4910.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0776.
HOGENOM	HOG000043828.
KO	K05787.
OMA	NHRAART.
ProtClustDB	PRK10753.
Enzyme and pathway databases
BioCyc	ECOL386585:GJFA-4923-MONOMER.
Family and domain databases
Gene3D	4.10.520.10. 1 hit.
InterPro	IPR023630. DNA-bd_HU/IHF. IPR000119. Hist_DNA-bd_bac. IPR020816. Histone-like_DNA-bd_CS. IPR010992. IHF-like_DNA-bd_dom. [Graphical view]
Pfam	PF00216. Bac_DNA_binding. 1 hit. [Graphical view]
PRINTS	PR01727. DNABINDINGHU.
SMART	SM00411. BHL. 1 hit. [Graphical view]
SUPFAM	SSF47729. IHF_like_DNA_bnd. 1 hit.
PROSITE	PS00045. HISTONE_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DBHA_ECO57

Accession

Primary (citable) accession number: P0ACF2
Secondary accession number(s): P02342

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program