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Protein

DNA-binding protein HU-alpha

Gene

hupA

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA condensation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein HU-alpha
Alternative name(s):
HU-2
NS2
Gene namesi
Name:hupA
Ordered Locus Names:Z5576, ECs4923
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001049361 – 90DNA-binding protein HU-alphaAdd BLAST90

Proteomic databases

PRIDEiP0ACF2

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Protein-protein interaction databases

STRINGi155864.Z5576

Structurei

3D structure databases

ProteinModelPortaliP0ACF2
SMRiP0ACF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105K70 Bacteria
COG0776 LUCA
HOGENOMiHOG000043828
KOiK05787
OMAiERKVPKF

Family and domain databases

Gene3Di4.10.520.10, 1 hit
InterProiView protein in InterPro
IPR000119 Hist_DNA-bd
IPR020816 Histone-like_DNA-bd_CS
IPR010992 IHF-like_DNA-bd_dom_sf
PANTHERiPTHR33175 PTHR33175, 1 hit
PfamiView protein in Pfam
PF00216 Bac_DNA_binding, 1 hit
PRINTSiPR01727 DNABINDINGHU
SMARTiView protein in SMART
SM00411 BHL, 1 hit
SUPFAMiSSF47729 SSF47729, 1 hit
PROSITEiView protein in PROSITE
PS00045 HISTONE_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P0ACF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKTQLIDVI AEKAELSKTQ AKAALESTLA AITESLKEGD AVQLVGFGTF
60 70 80 90
KVNHRAERTG RNPQTGKEIK IAAANVPAFV SGKALKDAVK
Length:90
Mass (Da):9,535
Last modified:July 21, 1986 - v1
Checksum:i6B5B8536FDBD13DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59197.1
BA000007 Genomic DNA Translation: BAB38346.1
PIRiA86092
C91244
RefSeqiNP_312950.1, NC_002695.1
WP_001044513.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG59197; AAG59197; Z5576
BAB38346; BAB38346; BAB38346
GeneIDi914933
KEGGiece:Z5576
ecs:ECs4923
PATRICifig|386585.9.peg.5148

Similar proteinsi

Entry informationi

Entry nameiDBHA_ECO57
AccessioniPrimary (citable) accession number: P0ACF2
Secondary accession number(s): P02342
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health