P0ACF1 (DBHA_ECOL6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-binding protein HU-alpha

Alternative name(s):
HU-2
NS2

Gene names

Name:	hupA
Ordered Locus Names:	c4957

Organism

Escherichia coli O6 [Complete proteome] [HAMAP]

Taxonomic identifier

217992 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions By similarity.
Subunit structure	Heterodimer of an alpha and a beta chain By similarity.
Sequence similarities	Belongs to the bacterial histone-like protein family.

Ontologies

Keywords
Biological process	DNA condensation
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromosome condensation Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 90	90	DNA-binding protein HU-alpha		PRO_0000104937

Sequences

	Sequence		Length	Mass (Da)
	P0ACF1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 6B5B8536FDBD13DC	FASTA	90	9,535
	10 20 30 40 50 60 MNKTQLIDVI AEKAELSKTQ AKAALESTLA AITESLKEGD AVQLVGFGTF KVNHRAERTG 70 80 90 RNPQTGKEIK IAAANVPAFV SGKALKDAVK

References

[1]

"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli." Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R. Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002) [PubMed: 12471157] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: O6:H1 / CFT073 / ATCC 700928 / UPEC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014075 Genomic DNA. Translation: AAN83385.1.
RefSeq	NP_756811.1. NC_004431.1.
3D structure databases
ProteinModelPortal	P0ACF1.
SMR	P0ACF1. Positions 1-90.
ModBase	Search...
Proteomic databases
PRIDE	P0ACF1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000045548; EBESCP00000043897; EBESCG00000044598.
GeneID	1039853.
GenomeReviews	Gene locus c4957 in contig AE014075_GR.
KEGG	ecc:c4957.
PATRIC	18287612. VBIEscCol75197_4656.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000010314.
HOGENOM	HBG705085.
OMA	MNSITYE.
PhylomeDB	P0ACF1.
ProtClustDB	PRK10753.
Family and domain databases
InterPro	IPR023630. DNA-bd_HU/IHF. IPR000119. Hist_DNA-bd_bac. IPR020816. Histone-like_DNA-bd_CS. IPR010992. IHF-like_DNA-bd. [Graphical view]
Gene3D	G3DSA:4.10.520.10. Hist_DNA_bd_bac. 1 hit.
KO	K05787.
Pfam	PF00216. Bac_DNA_binding. 1 hit. [Graphical view]
PRINTS	PR01727. DNABINDINGHU.
SMART	SM00411. BHL. 1 hit. [Graphical view]
SUPFAM	SSF47729. IHF_like_DNA_bnd. 1 hit.
PROSITE	PS00045. HISTONE_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DBHA_ECOL6

Accession

Primary (citable) accession number: P0ACF1
Secondary accession number(s): P02342

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program