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Protein

Protein HemY

Gene

hemY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in a late step of protoheme IX synthesis.

Pathwayi: protoheme biosynthesis

This protein is involved in the pathway protoheme biosynthesis, which is part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:EG10434-MONOMER.
ECOL316407:JW3774-MONOMER.
UniPathwayiUPA00252.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein HemY
Gene namesi
Name:hemY
Ordered Locus Names:b3802, JW3774
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10434. hemY.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 27HelicalSequence analysisAdd BLAST23
Topological domaini28 – 39PeriplasmicSequence analysisAdd BLAST12
Transmembranei40 – 62HelicalSequence analysisAdd BLAST23
Topological domaini63 – 398CytoplasmicSequence analysisAdd BLAST336

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352751 – 398Protein HemYAdd BLAST398

Proteomic databases

EPDiP0ACB7.
PaxDbiP0ACB7.
PRIDEiP0ACB7.

Interactioni

Protein-protein interaction databases

BioGridi4262608. 165 interactors.
DIPiDIP-47881N.
IntActiP0ACB7. 2 interactors.
STRINGi511145.b3802.

Structurei

3D structure databases

ProteinModelPortaliP0ACB7.
SMRiP0ACB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati118 – 151TPR 1Add BLAST34
Repeati328 – 361TPR 2Add BLAST34

Sequence similaritiesi

Contains 2 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410601J. Bacteria.
COG3071. LUCA.
HOGENOMiHOG000270888.
InParanoidiP0ACB7.
KOiK02498.
OMAiNPWSRRN.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR005254. Heme_biosyn_assoc_TPR_pro.
IPR010817. HemY_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF07219. HemY_N. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
TIGRFAMsiTIGR00540. TPR_hemY_coli. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKVLLLFVL LIAGIVVGPM IAGHQGYVLI QTDNYNIETS VTGLAIILIL
60 70 80 90 100
AMVVLFAIEW LLRRIFRTGA HTRGWFVGRK RRRARKQTEQ ALLKLAEGDY
110 120 130 140 150
QQVEKLMAKN ADHAEQPVVN YLLAAEAAQQ RGDEARANQH LERAAELAGN
160 170 180 190 200
DTIPVEITRV RLQLARNENH AARHGVDKLL EVTPRHPEVL RLAEQAYIRT
210 220 230 240 250
GAWSSLLDII PSMAKAHVGD EEHRAMLEQQ AWIGLMDQAR ADNGSEGLRN
260 270 280 290 300
WWKNQSRKTR HQVALQVAMA EHLIECDDHD TAQQIIIDGL KRQYDDRLLL
310 320 330 340 350
PIPRLKTNNP EQLEKVLRQQ IKNVGDRPLL WSTLGQSLMK HGEWQEASLA
360 370 380 390
FRAALKQRPD AYDYAWLADA LDRLHKPEEA AAMRRDGLML TLQNNPPQ
Length:398
Mass (Da):45,245
Last modified:November 8, 2005 - v1
Checksum:i56BDDC4E19099D3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12614 Genomic DNA. Translation: CAA31135.1.
M87049 Genomic DNA. Translation: AAA67598.1.
U00096 Genomic DNA. Translation: AAC76805.1.
AP009048 Genomic DNA. Translation: BAE77499.1.
PIRiS01694.
RefSeqiNP_418246.1. NC_000913.3.
WP_000921791.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76805; AAC76805; b3802.
BAE77499; BAE77499; BAE77499.
GeneIDi948311.
KEGGiecj:JW3774.
eco:b3802.
PATRICi32123103. VBIEscCol129921_3917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12614 Genomic DNA. Translation: CAA31135.1.
M87049 Genomic DNA. Translation: AAA67598.1.
U00096 Genomic DNA. Translation: AAC76805.1.
AP009048 Genomic DNA. Translation: BAE77499.1.
PIRiS01694.
RefSeqiNP_418246.1. NC_000913.3.
WP_000921791.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ACB7.
SMRiP0ACB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262608. 165 interactors.
DIPiDIP-47881N.
IntActiP0ACB7. 2 interactors.
STRINGi511145.b3802.

Proteomic databases

EPDiP0ACB7.
PaxDbiP0ACB7.
PRIDEiP0ACB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76805; AAC76805; b3802.
BAE77499; BAE77499; BAE77499.
GeneIDi948311.
KEGGiecj:JW3774.
eco:b3802.
PATRICi32123103. VBIEscCol129921_3917.

Organism-specific databases

EchoBASEiEB0429.
EcoGeneiEG10434. hemY.

Phylogenomic databases

eggNOGiENOG410601J. Bacteria.
COG3071. LUCA.
HOGENOMiHOG000270888.
InParanoidiP0ACB7.
KOiK02498.
OMAiNPWSRRN.

Enzyme and pathway databases

UniPathwayiUPA00252.
BioCyciEcoCyc:EG10434-MONOMER.
ECOL316407:JW3774-MONOMER.

Miscellaneous databases

PROiP0ACB7.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR005254. Heme_biosyn_assoc_TPR_pro.
IPR010817. HemY_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF07219. HemY_N. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
TIGRFAMsiTIGR00540. TPR_hemY_coli. 1 hit.
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEMY_ECOLI
AccessioniPrimary (citable) accession number: P0ACB7
Secondary accession number(s): P09128, Q2M8A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.