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Protein

Glutathione S-transferase GstB

Gene

gstB

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei53Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase GstB (EC:2.5.1.18)
Gene namesi
Name:gstB
Ordered Locus Names:SF0788, S0831
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001860201 – 208Glutathione S-transferase GstBAdd BLAST208

Proteomic databases

PaxDbiP0ACA9.
PRIDEiP0ACA9.

Structurei

3D structure databases

ProteinModelPortaliP0ACA9.
SMRiP0ACA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 83GST N-terminalAdd BLAST83
Domaini88 – 208GST C-terminalAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily.Curated

Phylogenomic databases

eggNOGiENOG4108TGY. Bacteria.
COG0625. LUCA.
HOGENOMiHOG000125757.
KOiK00799.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ACA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITLWGRNNS TNVKKVLLTL EELELPYEQI LAGREFGINH DADFLAMNPN
60 70 80 90 100
GLVPLLRDDE SDLILWESNA IVRYLAAQYG QKRLWIDSPA RRAEAEKWMD
110 120 130 140 150
WANQTLSNAH RGILMGLVRT PPEERDQAAI DASCKECDAL FALLDAELAK
160 170 180 190 200
VKWFSGDEFG VGDIAIAPFI YNLFNVGLTW TPRPNLQRWY QQLTERPAVR

KVVMIPVS
Length:208
Mass (Da):23,713
Last modified:November 8, 2005 - v1
Checksum:i8AD199E313B05094
GO

Sequence cautioni

The sequence AAN42421 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP16296 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN42421.1. Different initiation.
AE014073 Genomic DNA. Translation: AAP16296.1. Different initiation.
RefSeqiNP_706714.1. NC_004337.2.
WP_001295292.1. NZ_MSKF02000044.1.

Genome annotation databases

EnsemblBacteriaiAAN42421; AAN42421; SF0788.
AAP16296; AAP16296; S0831.
GeneIDi1023726.
KEGGisfl:SF0788.
sft:NCTC1_00800.
sfx:S0831.
PATRICifig|198214.7.peg.915.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGSTB_SHIFL
AccessioniPrimary (citable) accession number: P0ACA9
Secondary accession number(s): P75805, Q9R7R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: July 5, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families