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P0ACA9

- GSTB_SHIFL

UniProt

P0ACA9 - GSTB_SHIFL

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Protein
Glutathione S-transferase GstB
Gene
gstB, SF0788, S0831
Organism
Shigella flexneri
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121Glutathione By similarity
Binding sitei39 – 391Glutathione By similarity
Binding sitei53 – 531Glutathione; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase GstB (EC:2.5.1.18)
Gene namesi
Name:gstB
Ordered Locus Names:SF0788, S0831
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Glutathione S-transferase GstB
PRO_0000186020Add
BLAST

Proteomic databases

PaxDbiP0ACA9.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF0788.

Structurei

3D structure databases

ProteinModelPortaliP0ACA9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8383GST N-terminal
Add
BLAST
Domaini88 – 208121GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 682Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily.

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125757.
OrthoDBiEOG696BVR.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ACA9-1 [UniParc]FASTAAdd to Basket

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MITLWGRNNS TNVKKVLLTL EELELPYEQI LAGREFGINH DADFLAMNPN    50
GLVPLLRDDE SDLILWESNA IVRYLAAQYG QKRLWIDSPA RRAEAEKWMD 100
WANQTLSNAH RGILMGLVRT PPEERDQAAI DASCKECDAL FALLDAELAK 150
VKWFSGDEFG VGDIAIAPFI YNLFNVGLTW TPRPNLQRWY QQLTERPAVR 200
KVVMIPVS 208
Length:208
Mass (Da):23,713
Last modified:November 8, 2005 - v1
Checksum:i8AD199E313B05094
GO

Sequence cautioni

The sequence AAN42421.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAP16296.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN42421.1. Different initiation.
AE014073 Genomic DNA. Translation: AAP16296.1. Different initiation.
RefSeqiNP_706714.1. NC_004337.2.
NP_836490.1. NC_004741.1.

Genome annotation databases

EnsemblBacteriaiAAN42421; AAN42421; SF0788.
AAP16296; AAP16296; S0831.
GeneIDi1023726.
1077248.
KEGGisfl:SF0788.
sfx:S0831.
PATRICi18702773. VBIShiFle31049_0896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN42421.1 . Different initiation.
AE014073 Genomic DNA. Translation: AAP16296.1 . Different initiation.
RefSeqi NP_706714.1. NC_004337.2.
NP_836490.1. NC_004741.1.

3D structure databases

ProteinModelPortali P0ACA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198214.SF0788.

Proteomic databases

PaxDbi P0ACA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN42421 ; AAN42421 ; SF0788 .
AAP16296 ; AAP16296 ; S0831 .
GeneIDi 1023726.
1077248.
KEGGi sfl:SF0788.
sfx:S0831.
PATRICi 18702773. VBIShiFle31049_0896.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000125757.
OrthoDBi EOG696BVR.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiGSTB_SHIFL
AccessioniPrimary (citable) accession number: P0ACA9
Secondary accession number(s): P75805, Q9R7R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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