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P0ACA9

- GSTB_SHIFL

UniProt

P0ACA9 - GSTB_SHIFL

Protein

Glutathione S-transferase GstB

Gene

gstB

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei12 – 121GlutathioneBy similarity
    Binding sitei39 – 391GlutathioneBy similarity
    Binding sitei53 – 531Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase GstB (EC:2.5.1.18)
    Gene namesi
    Name:gstB
    Ordered Locus Names:SF0788, S0831
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Glutathione S-transferase GstBPRO_0000186020Add
    BLAST

    Proteomic databases

    PaxDbiP0ACA9.

    Interactioni

    Protein-protein interaction databases

    STRINGi198214.SF0788.

    Structurei

    3D structure databases

    ProteinModelPortaliP0ACA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8383GST N-terminalAdd
    BLAST
    Domaini88 – 208121GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni67 – 682Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000125757.
    OrthoDBiEOG696BVR.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0ACA9-1 [UniParc]FASTAAdd to Basket

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    MITLWGRNNS TNVKKVLLTL EELELPYEQI LAGREFGINH DADFLAMNPN    50
    GLVPLLRDDE SDLILWESNA IVRYLAAQYG QKRLWIDSPA RRAEAEKWMD 100
    WANQTLSNAH RGILMGLVRT PPEERDQAAI DASCKECDAL FALLDAELAK 150
    VKWFSGDEFG VGDIAIAPFI YNLFNVGLTW TPRPNLQRWY QQLTERPAVR 200
    KVVMIPVS 208
    Length:208
    Mass (Da):23,713
    Last modified:November 8, 2005 - v1
    Checksum:i8AD199E313B05094
    GO

    Sequence cautioni

    The sequence AAN42421.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAP16296.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN42421.1. Different initiation.
    AE014073 Genomic DNA. Translation: AAP16296.1. Different initiation.
    RefSeqiNP_706714.1. NC_004337.2.
    NP_836490.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN42421; AAN42421; SF0788.
    AAP16296; AAP16296; S0831.
    GeneIDi1023726.
    1077248.
    KEGGisfl:SF0788.
    sfx:S0831.
    PATRICi18702773. VBIShiFle31049_0896.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN42421.1 . Different initiation.
    AE014073 Genomic DNA. Translation: AAP16296.1 . Different initiation.
    RefSeqi NP_706714.1. NC_004337.2.
    NP_836490.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali P0ACA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF0788.

    Proteomic databases

    PaxDbi P0ACA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN42421 ; AAN42421 ; SF0788 .
    AAP16296 ; AAP16296 ; S0831 .
    GeneIDi 1023726.
    1077248.
    KEGGi sfl:SF0788.
    sfx:S0831.
    PATRICi 18702773. VBIShiFle31049_0896.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000125757.
    OrthoDBi EOG696BVR.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiGSTB_SHIFL
    AccessioniPrimary (citable) accession number: P0ACA9
    Secondary accession number(s): P75805, Q9R7R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3