P0AC98 (YAAH_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inner membrane protein yaaH

Gene names

Name:	yaaH
Ordered Locus Names:	b0010, JW0009

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the GPR1/FUN34/yaaH family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Inner membrane protein yaaH		PRO_0000135703
Regions
	Topological domain	1 – 13	13	Cytoplasmic Potential
	Transmembrane	14 – 34	21	Helical; Potential
	Topological domain	35	1	Periplasmic Potential
	Transmembrane	36 – 56	21	Helical; Potential
	Topological domain	57 – 63	7	Cytoplasmic Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Topological domain	85 – 97	13	Periplasmic Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Topological domain	119 – 122	4	Cytoplasmic Potential
	Transmembrane	123 – 143	21	Helical; Potential
	Topological domain	144 – 148	5	Periplasmic Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Topological domain	170 – 188	19	Cytoplasmic Potential
Experimental info
	Sequence conflict	111	1	L → V Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P0AC98 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 972101DD5949EBF4	FASTA	188	20,071
	10 20 30 40 50 60 MGNTKLANPA PLGLMGFGMT TILLNLHNVG YFALDGIILA MGIFYGGIAQ IFAGLLEYKK 70 80 90 100 110 120 GNTFGLTAFT SYGSFWLTLV AILLMPKLGL TDAPNAQFLG VYLGLWGVFT LFMFFGTLKG 130 140 150 160 170 180 ARVLQFVFFS LTVLFALLAI GNIAGNAAII HFAGWIGLIC GASAIYLAMG EVLNEQFGRT VLPIGESH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Five open reading frames upstream of the dnaK gene of E. coli." James R., Dean D.O., Debbage J. DNA Seq. 3:327-332(1993) [PubMed: 8400364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region." Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N., Isono K., Mizobuchi K., Nakata A. Nucleic Acids Res. 20:3305-3308(1992) [PubMed: 1630901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO 111. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Global topology analysis of the Escherichia coli inner membrane proteome." Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G. Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: K12 / MG1655 / ATCC 47076.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X67700 Genomic DNA. Translation: CAA47931.1. U00096 Genomic DNA. Translation: AAC73121.1. AP009048 Genomic DNA. Translation: BAB96588.2.
PIR	E56688.
RefSeq	NP_414551.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P0AC98.
ModBase	Search...
Protein family/group databases
TCDB	2.A.96.1.1. YaaH family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000002107; EBESCP00000002107; EBESCG00000001725. EBESCT00000017825; EBESCP00000017116; EBESCG00000016881.
GeneID	944792.
GenomeReviews	Gene locus JW0009 in contig AP009048_GR. Gene locus b0010 in contig U00096_GR.
KEGG	ecj:JW0009. eco:b0010.
PATRIC	32115115. VBIEscCol129921_0009.
Organism-specific databases
EchoBASE	EB1474.
EcoGene	EG11512. yaaH.
Phylogenomic databases
eggNOG	COG1584.
GeneTree	EBGT00050000011503.
HOGENOM	HBG736287.
OMA	GIMEWKK.
PhylomeDB	P0AC98.
ProtClustDB	PRK10659.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11512-MONOMER.
Gene expression databases
Genevestigator	P0AC98.
Family and domain databases
InterPro	IPR000791. Grp1_Fun34_YaaH. [Graphical view]
KO	K07034.
Pfam	PF01184. Grp1_Fun34_YaaH. 1 hit. [Graphical view]
PROSITE	PS01114. GPR1_FUN34_YAAH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YAAH_ECOLI

Accession

Primary (citable) accession number: P0AC98
Secondary accession number(s): P28695, Q8KMY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program