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Protein

High-affinity gluconate transporter

Gene

gntP

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose.By similarity

Pathwayi: D-gluconate degradation

This protein is involved in the pathway D-gluconate degradation, which is part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the pathway D-gluconate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processGluconate utilization, Sugar transport, Transport

Enzyme and pathway databases

UniPathwayiUPA00792

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity gluconate transporter
Alternative name(s):
Gluconate permease 3
Gnt-III system
Gene namesi
Name:gntP
Ordered Locus Names:Z5919, ECs5280
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 28PeriplasmicSequence analysis7
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 54CytoplasmicSequence analysis5
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 103PeriplasmicSequence analysisAdd BLAST28
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 126CytoplasmicSequence analysis2
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 175PeriplasmicSequence analysisAdd BLAST28
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 224CytoplasmicSequence analysisAdd BLAST28
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 260PeriplasmicSequence analysisAdd BLAST15
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Topological domaini282 – 294CytoplasmicSequence analysisAdd BLAST13
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 329PeriplasmicSequence analysisAdd BLAST14
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351CytoplasmicSequence analysis1
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 374PeriplasmicSequence analysis2
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 426CytoplasmicSequence analysisAdd BLAST31
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000619331 – 447High-affinity gluconate transporterAdd BLAST447

Interactioni

Protein-protein interaction databases

STRINGi155864.Z5919

Structurei

3D structure databases

ProteinModelPortaliP0AC95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GntP permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107EFN Bacteria
COG2610 LUCA
HOGENOMiHOG000237115
KOiK16321
OMAiNTITLMY

Family and domain databases

InterProiView protein in InterPro
IPR003474 Glcn_transporter
PANTHERiPTHR30354 PTHR30354, 1 hit
PfamiView protein in Pfam
PF02447 GntP_permease, 1 hit
PIRSFiPIRSF002746 Gluconate_transporter, 1 hit
TIGRFAMsiTIGR00791 gntP, 1 hit

Sequencei

Sequence statusi: Complete.

P0AC95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVLNILWVV FGIGLMLVLN LKFKINSMVA LLVAALSVGM LAGMDLMSLL
60 70 80 90 100
HTMKAGFGNT LGELAIIVVF GAVIGKLMVD SGAAHQIAHT LLARLGLRYV
110 120 130 140 150
QLSVIIIGLI FGLAMFYEVA FIMLAPLVIV IAAEAKIPFL KLAIPAVAAA
160 170 180 190 200
TTAHSLFPPQ PGPVALVNAY GADMGMVYIY GVLVTIPSVI CAGLILPKFL
210 220 230 240 250
GNLERPTPSF LKADQPVDMN NLPSFGVSIL VPLIPAIIMI STTIANIWLV
260 270 280 290 300
KDTPAWEVVN FIGSSPIAMF IAMVVAFVLF GTARGHDMQW VMNAFESAVK
310 320 330 340 350
SIAMVILIIG AGGVLKQTII DTGIGDTIGM LMSHGNISPY IMAWLITVLI
360 370 380 390 400
RLATGQGVVS AMTAAGIISA AILDPATGQL VGVNPALLVL ATAAGSNTLT
410 420 430 440
HINDASFWLF KGYFDLSVKD TLKTWGLLEL VNSVVGLIIV LIISMVA
Length:447
Mass (Da):47,138
Last modified:November 8, 2005 - v1
Checksum:i03B3AD16A61330E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG59503.1
BA000007 Genomic DNA Translation: BAB38703.1
PIRiC86130
H91288
RefSeqiNP_313307.1, NC_002695.1
WP_000558251.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG59503; AAG59503; Z5919
BAB38703; BAB38703; BAB38703
GeneIDi913673
KEGGiece:Z5919
ecs:ECs5280
PATRICifig|386585.9.peg.5517

Similar proteinsi

Entry informationi

Entry nameiGNTP_ECO57
AccessioniPrimary (citable) accession number: P0AC95
Secondary accession number(s): P39373
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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