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Protein

High-affinity gluconate transporter

Gene

gntP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose.

Pathwayi: D-gluconate degradation

This protein is involved in the pathway D-gluconate degradation, which is part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the pathway D-gluconate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

  • gluconate transmembrane transporter activity Source: EcoCyc
  • sugar:proton symporter activity Source: EcoCyc

GO - Biological processi

  • D-gluconate catabolic process Source: UniProtKB-UniPathway
  • gluconate transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Gluconate utilization, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GNTP-MONOMER.
ECOL316407:JW4284-MONOMER.
MetaCyc:GNTP-MONOMER.
UniPathwayiUPA00792.

Protein family/group databases

TCDBi2.A.8.1.3. the gluconate:h(+) symporter (gntp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity gluconate transporter
Alternative name(s):
Gluconate permease 3
Gnt-III system
Gene namesi
Name:gntP
Synonyms:yjiB
Ordered Locus Names:b4321, JW4284
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12563. gntP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 28PeriplasmicSequence analysis7
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 54CytoplasmicSequence analysis5
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 103PeriplasmicSequence analysisAdd BLAST28
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Topological domaini125 – 126CytoplasmicSequence analysis2
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 175PeriplasmicSequence analysisAdd BLAST28
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 224CytoplasmicSequence analysisAdd BLAST28
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 260PeriplasmicSequence analysisAdd BLAST15
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Topological domaini282 – 294CytoplasmicSequence analysisAdd BLAST13
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 329PeriplasmicSequence analysisAdd BLAST14
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Topological domaini351CytoplasmicSequence analysis1
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Topological domaini373 – 374PeriplasmicSequence analysis2
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21
Topological domaini396 – 426CytoplasmicSequence analysisAdd BLAST31
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoliWiki
  • membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000619321 – 447High-affinity gluconate transporterAdd BLAST447

Proteomic databases

PaxDbiP0AC94.
PRIDEiP0AC94.

Interactioni

Protein-protein interaction databases

BioGridi4261000. 6 interactors.
STRINGi511145.b4321.

Structurei

3D structure databases

ProteinModelPortaliP0AC94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GntP permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107EFN. Bacteria.
COG2610. LUCA.
HOGENOMiHOG000237115.
InParanoidiP0AC94.
KOiK16321.
OMAiAIDENDR.
PhylomeDBiP0AC94.

Family and domain databases

InterProiIPR003474. Glcn_transporter.
[Graphical view]
PfamiPF02447. GntP_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF002746. Gluconate_transporter. 1 hit.
TIGRFAMsiTIGR00791. gntP. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AC94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVLNILWVV FGIGLMLVLN LKFKINSMVA LLVAALSVGM LAGMDLMSLL
60 70 80 90 100
HTMKAGFGNT LGELAIIVVF GAVIGKLMVD SGAAHQIAHT LLARLGLRYV
110 120 130 140 150
QLSVIIIGLI FGLAMFYEVA FIMLAPLVIV IAAEAKIPFL KLAIPAVAAA
160 170 180 190 200
TTAHSLFPPQ PGPVALVNAY GADMGMVYIY GVLVTIPSVI CAGLILPKFL
210 220 230 240 250
GNLERPTPSF LKADQPVDMN NLPSFGVSIL VPLIPAIIMI STTIANIWLV
260 270 280 290 300
KDTPAWEVVN FIGSSPIAMF IAMVVAFVLF GTARGHDMQW VMNAFESAVK
310 320 330 340 350
SIAMVILIIG AGGVLKQTII DTGIGDTIGM LMSHGNISPY IMAWLITVLI
360 370 380 390 400
RLATGQGVVS AMTAAGIISA AILDPATGQL VGVNPALLVL ATAAGSNTLT
410 420 430 440
HINDASFWLF KGYFDLSVKD TLKTWGLLEL VNSVVGLIIV LIISMVA
Length:447
Mass (Da):47,138
Last modified:November 8, 2005 - v1
Checksum:i03B3AD16A61330E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63E → A in CAA62859 (PubMed:8550444).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91735 Genomic DNA. Translation: CAA62859.1.
U14003 Genomic DNA. Translation: AAA97217.1.
U00096 Genomic DNA. Translation: AAC77277.1.
AP009048 Genomic DNA. Translation: BAE78314.1.
PIRiS56546.
RefSeqiNP_418741.1. NC_000913.3.
WP_000558251.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77277; AAC77277; b4321.
BAE78314; BAE78314; BAE78314.
GeneIDi948848.
KEGGiecj:JW4284.
eco:b4321.
PATRICi32124238. VBIEscCol129921_4462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91735 Genomic DNA. Translation: CAA62859.1.
U14003 Genomic DNA. Translation: AAA97217.1.
U00096 Genomic DNA. Translation: AAC77277.1.
AP009048 Genomic DNA. Translation: BAE78314.1.
PIRiS56546.
RefSeqiNP_418741.1. NC_000913.3.
WP_000558251.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AC94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261000. 6 interactors.
STRINGi511145.b4321.

Protein family/group databases

TCDBi2.A.8.1.3. the gluconate:h(+) symporter (gntp) family.

Proteomic databases

PaxDbiP0AC94.
PRIDEiP0AC94.

Protocols and materials databases

DNASUi948848.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77277; AAC77277; b4321.
BAE78314; BAE78314; BAE78314.
GeneIDi948848.
KEGGiecj:JW4284.
eco:b4321.
PATRICi32124238. VBIEscCol129921_4462.

Organism-specific databases

EchoBASEiEB2451.
EcoGeneiEG12563. gntP.

Phylogenomic databases

eggNOGiENOG4107EFN. Bacteria.
COG2610. LUCA.
HOGENOMiHOG000237115.
InParanoidiP0AC94.
KOiK16321.
OMAiAIDENDR.
PhylomeDBiP0AC94.

Enzyme and pathway databases

UniPathwayiUPA00792.
BioCyciEcoCyc:GNTP-MONOMER.
ECOL316407:JW4284-MONOMER.
MetaCyc:GNTP-MONOMER.

Miscellaneous databases

PROiP0AC94.

Family and domain databases

InterProiIPR003474. Glcn_transporter.
[Graphical view]
PfamiPF02447. GntP_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF002746. Gluconate_transporter. 1 hit.
TIGRFAMsiTIGR00791. gntP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGNTP_ECOLI
AccessioniPrimary (citable) accession number: P0AC94
Secondary accession number(s): P39373, Q2M5Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.