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P0AC83

- LGUL_SHIFL

UniProt

P0AC83 - LGUL_SHIFL

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Protein

Lactoylglutathione lyase

Gene

gloA

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.By similarity

Catalytic activityi

(R)-S-lactoylglutathione = glutathione + methylglyoxal.

Cofactori

Ni2+By similarityNote: Binds 1 nickel ion per subunit. In the homodimer, two nickel ions are bound between subunits.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Nickel; via tele nitrogen; shared with dimeric partnerBy similarity
Binding sitei9 – 91Substrate; shared with dimeric partnerBy similarity
Metal bindingi56 – 561Nickel; shared with dimeric partnerBy similarity
Binding sitei60 – 601Substrate; shared with dimeric partnerBy similarity
Metal bindingi74 – 741Nickel; via tele nitrogenBy similarity
Binding sitei74 – 741SubstrateBy similarity
Active sitei122 – 1221Proton donor/acceptorBy similarity
Metal bindingi122 – 1221NickelBy similarity

GO - Molecular functioni

  1. lactoylglutathione lyase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

UniPathwayiUPA00619; UER00675.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactoylglutathione lyase (EC:4.4.1.5)
Alternative name(s):
Aldoketomutase
Glyoxalase I
Short name:
Glx I
Ketone-aldehyde mutase
Methylglyoxalase
S-D-lactoylglutathione methylglyoxal lyase
Gene namesi
Name:gloA
Ordered Locus Names:SF1678, S1810
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 135135Lactoylglutathione lyasePRO_0000168092Add
BLAST

Proteomic databases

PaxDbiP0AC83.
PRIDEiP0AC83.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi198214.SF1678.

Structurei

3D structure databases

ProteinModelPortaliP0AC83.
SMRiP0AC83. Positions 1-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glyoxalase I family.Curated

Phylogenomic databases

eggNOGiCOG0346.
HOGENOMiHOG000232011.
KOiK01759.
OMAiIGEEDIY.
OrthoDBiEOG6DVJXX.

Family and domain databases

Gene3Di3.10.180.10. 1 hit.
InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
IPR004361. Glyoxalase_1.
IPR018146. Glyoxalase_1_CS.
[Graphical view]
PfamiPF00903. Glyoxalase. 1 hit.
[Graphical view]
SUPFAMiSSF54593. SSF54593. 1 hit.
TIGRFAMsiTIGR00068. glyox_I. 1 hit.
PROSITEiPS00934. GLYOXALASE_I_1. 1 hit.
PS00935. GLYOXALASE_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AC83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLLHTMLRV GDLQRSIDFY TKVLGMKLLR TSENPEYKYS LAFVGYGPET
60 70 80 90 100
EEAVIELTYN WGVDKYELGT AYGHIALSVD NAAEACEKIR QNGGNVTREA
110 120 130
GPVKGGTTVI AFVEDPDGYK IELIEEKDAG RGLGN
Length:135
Mass (Da):14,920
Last modified:November 8, 2005 - v1
Checksum:iA53FC5412B9A6CE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43259.1.
AE014073 Genomic DNA. Translation: AAP17147.1.
RefSeqiNP_707552.1. NC_004337.2.
NP_837338.1. NC_004741.1.

Genome annotation databases

EnsemblBacteriaiAAN43259; AAN43259; SF1678.
AAP17147; AAP17147; S1810.
GeneIDi1024857.
1078150.
KEGGisfl:SF1678.
sfx:S1810.
PATRICi18705008. VBIShiFle31049_2002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43259.1 .
AE014073 Genomic DNA. Translation: AAP17147.1 .
RefSeqi NP_707552.1. NC_004337.2.
NP_837338.1. NC_004741.1.

3D structure databases

ProteinModelPortali P0AC83.
SMRi P0AC83. Positions 1-126.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198214.SF1678.

Proteomic databases

PaxDbi P0AC83.
PRIDEi P0AC83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN43259 ; AAN43259 ; SF1678 .
AAP17147 ; AAP17147 ; S1810 .
GeneIDi 1024857.
1078150.
KEGGi sfl:SF1678.
sfx:S1810.
PATRICi 18705008. VBIShiFle31049_2002.

Phylogenomic databases

eggNOGi COG0346.
HOGENOMi HOG000232011.
KOi K01759.
OMAi IGEEDIY.
OrthoDBi EOG6DVJXX.

Enzyme and pathway databases

UniPathwayi UPA00619 ; UER00675 .

Family and domain databases

Gene3Di 3.10.180.10. 1 hit.
InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
IPR004360. Glyas_Fos-R_dOase_dom.
IPR004361. Glyoxalase_1.
IPR018146. Glyoxalase_1_CS.
[Graphical view ]
Pfami PF00903. Glyoxalase. 1 hit.
[Graphical view ]
SUPFAMi SSF54593. SSF54593. 1 hit.
TIGRFAMsi TIGR00068. glyox_I. 1 hit.
PROSITEi PS00934. GLYOXALASE_I_1. 1 hit.
PS00935. GLYOXALASE_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiLGUL_SHIFL
AccessioniPrimary (citable) accession number: P0AC83
Secondary accession number(s): P77036, Q59384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3