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P0AC83

- LGUL_SHIFL

UniProt

P0AC83 - LGUL_SHIFL

Protein

Lactoylglutathione lyase

Gene

gloA

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.By similarity

    Catalytic activityi

    (R)-S-lactoylglutathione = glutathione + methylglyoxal.

    Cofactori

    Binds 1 nickel ion per subunit. In the homodimer, two nickel ions are bound between subunits By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi5 – 51Nickel; via tele nitrogen; shared with dimeric partnerBy similarity
    Binding sitei9 – 91Substrate; shared with dimeric partnerBy similarity
    Metal bindingi56 – 561Nickel; shared with dimeric partnerBy similarity
    Binding sitei60 – 601Substrate; shared with dimeric partnerBy similarity
    Metal bindingi74 – 741Nickel; via tele nitrogenBy similarity
    Binding sitei74 – 741SubstrateBy similarity
    Active sitei122 – 1221Proton donor/acceptorBy similarity
    Metal bindingi122 – 1221NickelBy similarity

    GO - Molecular functioni

    1. lactoylglutathione lyase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Metal-binding, Nickel

    Enzyme and pathway databases

    UniPathwayiUPA00619; UER00675.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lactoylglutathione lyase (EC:4.4.1.5)
    Alternative name(s):
    Aldoketomutase
    Glyoxalase I
    Short name:
    Glx I
    Ketone-aldehyde mutase
    Methylglyoxalase
    S-D-lactoylglutathione methylglyoxal lyase
    Gene namesi
    Name:gloA
    Ordered Locus Names:SF1678, S1810
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 135135Lactoylglutathione lyasePRO_0000168092Add
    BLAST

    Proteomic databases

    PaxDbiP0AC83.
    PRIDEiP0AC83.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi198214.SF1678.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AC83.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glyoxalase I family.Curated

    Phylogenomic databases

    eggNOGiCOG0346.
    HOGENOMiHOG000232011.
    KOiK01759.
    OMAiIGEEDIY.
    OrthoDBiEOG6DVJXX.

    Family and domain databases

    Gene3Di3.10.180.10. 1 hit.
    InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    IPR004361. Glyoxalase_1.
    IPR018146. Glyoxalase_1_CS.
    [Graphical view]
    PfamiPF00903. Glyoxalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF54593. SSF54593. 1 hit.
    TIGRFAMsiTIGR00068. glyox_I. 1 hit.
    PROSITEiPS00934. GLYOXALASE_I_1. 1 hit.
    PS00935. GLYOXALASE_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0AC83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLLHTMLRV GDLQRSIDFY TKVLGMKLLR TSENPEYKYS LAFVGYGPET    50
    EEAVIELTYN WGVDKYELGT AYGHIALSVD NAAEACEKIR QNGGNVTREA 100
    GPVKGGTTVI AFVEDPDGYK IELIEEKDAG RGLGN 135
    Length:135
    Mass (Da):14,920
    Last modified:November 8, 2005 - v1
    Checksum:iA53FC5412B9A6CE3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN43259.1.
    AE014073 Genomic DNA. Translation: AAP17147.1.
    RefSeqiNP_707552.1. NC_004337.2.
    NP_837338.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN43259; AAN43259; SF1678.
    AAP17147; AAP17147; S1810.
    GeneIDi1024857.
    1078150.
    KEGGisfl:SF1678.
    sfx:S1810.
    PATRICi18705008. VBIShiFle31049_2002.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN43259.1 .
    AE014073 Genomic DNA. Translation: AAP17147.1 .
    RefSeqi NP_707552.1. NC_004337.2.
    NP_837338.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali P0AC83.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF1678.

    Proteomic databases

    PaxDbi P0AC83.
    PRIDEi P0AC83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN43259 ; AAN43259 ; SF1678 .
    AAP17147 ; AAP17147 ; S1810 .
    GeneIDi 1024857.
    1078150.
    KEGGi sfl:SF1678.
    sfx:S1810.
    PATRICi 18705008. VBIShiFle31049_2002.

    Phylogenomic databases

    eggNOGi COG0346.
    HOGENOMi HOG000232011.
    KOi K01759.
    OMAi IGEEDIY.
    OrthoDBi EOG6DVJXX.

    Enzyme and pathway databases

    UniPathwayi UPA00619 ; UER00675 .

    Family and domain databases

    Gene3Di 3.10.180.10. 1 hit.
    InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    IPR004361. Glyoxalase_1.
    IPR018146. Glyoxalase_1_CS.
    [Graphical view ]
    Pfami PF00903. Glyoxalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54593. SSF54593. 1 hit.
    TIGRFAMsi TIGR00068. glyox_I. 1 hit.
    PROSITEi PS00934. GLYOXALASE_I_1. 1 hit.
    PS00935. GLYOXALASE_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiLGUL_SHIFL
    AccessioniPrimary (citable) accession number: P0AC83
    Secondary accession number(s): P77036, Q59384
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3