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Protein

Glutaredoxin 4

Gene

grxD

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22GlutathioneBy similarity1
Metal bindingi30Iron-sulfur (2Fe-2S); shared with dimeric partnerBy similarity1
Binding sitei59GlutathioneBy similarity1
Binding sitei71Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin 4
Short name:
Grx4
Alternative name(s):
Monothiol glutaredoxin
Gene namesi
Name:grxD
Synonyms:ydhD
Ordered Locus Names:Z2676, ECs2363
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001022581 – 115Glutaredoxin 4Add BLAST115

Proteomic databases

PRIDEiP0AC71

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi155864.Z2676

Structurei

3D structure databases

ProteinModelPortaliP0AC71
SMRiP0AC71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 107GlutaredoxinPROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 85Glutathione bindingBy similarity2

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105M2J Bacteria
COG0278 LUCA
HOGENOMiHOG000095211
KOiK07390
OMAiKGTKLMP

Family and domain databases

CDDicd03028 GRX_PICOT_like, 1 hit
InterProiView protein in InterPro
IPR002109 Glutaredoxin
IPR033658 GRX_PICOT-like
IPR014434 Monothiol_GRX
IPR004480 Monothiol_GRX-rel
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR10293 PTHR10293, 1 hit
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PIRSFiPIRSF005894 Monothiol_GRX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00365 TIGR00365, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0AC71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTIEKIQR QIAENPILLY MKGSPKLPSC GFSAQAVQAL AACGERFAYV
60 70 80 90 100
DILQNPDIRA ELPKYANWPT FPQLWVDGEL VGGCDIVIEM YQRGELQQLI
110
KETAAKYKSE EPDAE
Length:115
Mass (Da):12,879
Last modified:November 8, 2005 - v1
Checksum:i254B540430632645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG56643.1
BA000007 Genomic DNA Translation: BAB35786.1
PIRiC90924
G85772
RefSeqiNP_310390.1, NC_002695.1
WP_000108172.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG56643; AAG56643; Z2676
BAB35786; BAB35786; BAB35786
GeneIDi912690
KEGGiece:Z2676
ecs:ECs2363
PATRICifig|386585.9.peg.2472

Similar proteinsi

Entry informationi

Entry nameiGLRX4_ECO57
AccessioniPrimary (citable) accession number: P0AC71
Secondary accession number(s): P37010, P77424
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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