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Protein

Glutaredoxin-4

Gene

grxD

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22GlutathioneBy similarity1
Metal bindingi30Iron-sulfur (2Fe-2S); shared with dimeric partnerBy similarity1
Binding sitei59GlutathioneBy similarity1
Binding sitei71Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciECOO157:YDHD-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-4
Short name:
Grx4
Alternative name(s):
Monothiol glutaredoxin
Gene namesi
Name:grxD
Synonyms:ydhD
Ordered Locus Names:Z2676, ECs2363
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001022581 – 115Glutaredoxin-4Add BLAST115

Proteomic databases

PRIDEiP0AC71.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-1258006.
STRINGi155864.Z2676.

Structurei

3D structure databases

ProteinModelPortaliP0AC71.
SMRiP0AC71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 107GlutaredoxinPROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 85Glutathione bindingBy similarity2

Sequence similaritiesi

Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105M2J. Bacteria.
COG0278. LUCA.
HOGENOMiHOG000095211.
KOiK07390.
OMAiHEFIDNE.

Family and domain databases

CDDicd03028. GRX_PICOT_like. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR002109. Glutaredoxin.
IPR033658. GRX_PICOT-like.
IPR014434. Monothiol_GRX.
IPR004480. Monothiol_GRX-rel.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10293. PTHR10293. 1 hit.
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF005894. Monothiol_GRX. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00365. TIGR00365. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AC71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTIEKIQR QIAENPILLY MKGSPKLPSC GFSAQAVQAL AACGERFAYV
60 70 80 90 100
DILQNPDIRA ELPKYANWPT FPQLWVDGEL VGGCDIVIEM YQRGELQQLI
110
KETAAKYKSE EPDAE
Length:115
Mass (Da):12,879
Last modified:November 8, 2005 - v1
Checksum:i254B540430632645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG56643.1.
BA000007 Genomic DNA. Translation: BAB35786.1.
PIRiC90924.
G85772.
RefSeqiNP_310390.1. NC_002695.1.
WP_000108172.1. NZ_LPWC02000002.1.

Genome annotation databases

EnsemblBacteriaiAAG56643; AAG56643; Z2676.
BAB35786; BAB35786; BAB35786.
GeneIDi912690.
KEGGiece:Z2676.
ecs:ECs2363.
PATRICi18354056. VBIEscCol44059_2241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG56643.1.
BA000007 Genomic DNA. Translation: BAB35786.1.
PIRiC90924.
G85772.
RefSeqiNP_310390.1. NC_002695.1.
WP_000108172.1. NZ_LPWC02000002.1.

3D structure databases

ProteinModelPortaliP0AC71.
SMRiP0AC71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1258006.
STRINGi155864.Z2676.

Proteomic databases

PRIDEiP0AC71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG56643; AAG56643; Z2676.
BAB35786; BAB35786; BAB35786.
GeneIDi912690.
KEGGiece:Z2676.
ecs:ECs2363.
PATRICi18354056. VBIEscCol44059_2241.

Phylogenomic databases

eggNOGiENOG4105M2J. Bacteria.
COG0278. LUCA.
HOGENOMiHOG000095211.
KOiK07390.
OMAiHEFIDNE.

Enzyme and pathway databases

BioCyciECOO157:YDHD-MONOMER.

Family and domain databases

CDDicd03028. GRX_PICOT_like. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR002109. Glutaredoxin.
IPR033658. GRX_PICOT-like.
IPR014434. Monothiol_GRX.
IPR004480. Monothiol_GRX-rel.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10293. PTHR10293. 1 hit.
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF005894. Monothiol_GRX. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00365. TIGR00365. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLRX4_ECO57
AccessioniPrimary (citable) accession number: P0AC71
Secondary accession number(s): P37010, P77424
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.