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Protein

Glutaredoxin 4

Gene

grxD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei22Glutathione1 Publication1
Metal bindingi30Iron-sulfur (2Fe-2S); shared with dimeric partner1
Binding sitei59Glutathione1 Publication1
Binding sitei71Glutathione; via amide nitrogen and carbonyl oxygen1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12181-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin 4
Short name:
Grx4
Alternative name(s):
Monothiol glutaredoxin
Gene namesi
Name:grxD
Synonyms:ydhD
Ordered Locus Names:b1654, JW1646
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12181 grxD

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001022571 – 115Glutaredoxin 4Add BLAST115

Proteomic databases

EPDiP0AC69
PaxDbiP0AC69
PRIDEiP0AC69

2D gel databases

SWISS-2DPAGEiP0AC69

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
bolAP0ABE24EBI-545828,EBI-545774

Protein-protein interaction databases

BioGridi4260269, 437 interactors
DIPiDIP-11729N
IntActiP0AC69, 18 interactors
STRINGi316385.ECDH10B_1788

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 14Combined sources12
Beta strandi16 – 23Combined sources8
Beta strandi25 – 30Combined sources6
Helixi31 – 41Combined sources11
Beta strandi48 – 51Combined sources4
Helixi52 – 54Combined sources3
Helixi56 – 66Combined sources11
Beta strandi67 – 70Combined sources4
Beta strandi73 – 76Combined sources4
Beta strandi79 – 83Combined sources5
Helixi84 – 92Combined sources9
Helixi95 – 107Combined sources13
Beta strandi108 – 110Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YKANMR-A1-115[»]
2WCIX-ray1.90A/B1-115[»]
ProteinModelPortaliP0AC69
SMRiP0AC69
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AC69

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 107GlutaredoxinPROSITE-ProRule annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 85Glutathione binding2

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105M2J Bacteria
COG0278 LUCA
HOGENOMiHOG000095211
InParanoidiP0AC69
KOiK07390
OMAiKGTKLMP
PhylomeDBiP0AC69

Family and domain databases

CDDicd03028 GRX_PICOT_like, 1 hit
InterProiView protein in InterPro
IPR002109 Glutaredoxin
IPR033658 GRX_PICOT-like
IPR014434 Monothiol_GRX
IPR004480 Monothiol_GRX-rel
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR10293 PTHR10293, 1 hit
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PIRSFiPIRSF005894 Monothiol_GRX, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00365 TIGR00365, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0AC69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTIEKIQR QIAENPILLY MKGSPKLPSC GFSAQAVQAL AACGERFAYV
60 70 80 90 100
DILQNPDIRA ELPKYANWPT FPQLWVDGEL VGGCDIVIEM YQRGELQQLI
110
KETAAKYKSE EPDAE
Length:115
Mass (Da):12,879
Last modified:November 8, 2005 - v1
Checksum:i254B540430632645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74726.1
AP009048 Genomic DNA Translation: BAA15420.1
L01622 Genomic DNA Translation: AAC37010.1
PIRiH64922
RefSeqiNP_416171.1, NC_000913.3
WP_000108172.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74726; AAC74726; b1654
BAA15420; BAA15420; BAA15420
GeneIDi946169
KEGGiecj:JW1646
eco:b1654
PATRICifig|1411691.4.peg.605

Similar proteinsi

Entry informationi

Entry nameiGLRX4_ECOLI
AccessioniPrimary (citable) accession number: P0AC69
Secondary accession number(s): P37010, P77424
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health