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Protein

Glutaredoxin-like protein NrdH

Gene

nrdH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Electron transport system for the ribonucleotide reductase system NrdEF.

GO - Molecular functioni

  • electron carrier activity Source: EcoCyc
  • protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  • cell redox homeostasis Source: EcoCyc
  • positive regulation of oxidoreductase activity Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7401-MONOMER.
ECOL316407:JW2648-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-like protein NrdH
Gene namesi
Name:nrdH
Synonyms:ygaN
Ordered Locus Names:b2673, JW2648
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13286. nrdH.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001416381 – 81Glutaredoxin-like protein NrdHAdd BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 14Redox-active

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0AC65.
PRIDEiP0AC65.

Expressioni

Inductioni

Induced 2-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260693. 11 interactors.
DIPiDIP-48164N.
IntActiP0AC65. 7 interactors.
STRINGi511145.b2673.

Structurei

Secondary structure

181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi12 – 23Combined sources12
Beta strandi29 – 32Combined sources4
Turni33 – 35Combined sources3
Helixi37 – 45Combined sources9
Beta strandi53 – 56Combined sources4
Beta strandi59 – 63Combined sources5
Helixi66 – 69Combined sources4
Helixi70 – 72Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H75X-ray1.70A1-81[»]
ProteinModelPortaliP0AC65.
SMRiP0AC65.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AC65.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 81GlutaredoxinPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105WAZ. Bacteria.
COG0695. LUCA.
HOGENOMiHOG000095206.
InParanoidiP0AC65.
KOiK06191.
OMAiEQHWAGF.
PhylomeDBiP0AC65.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011909. GlrX_NrdH.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02194. GlrX_NrdH. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AC65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRITIYTRND CVQCHATKRA MENRGFDFEM INVDRVPEAA EALRAQGFRQ
60 70 80
LPVVIAGDLS WSGFRPDMIN RLHPAPHAAS A
Length:81
Mass (Da):9,139
Last modified:November 8, 2005 - v1
Checksum:i6D0878E9CD133137
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79787 Genomic DNA. Translation: CAA56184.1.
U00096 Genomic DNA. Translation: AAC75720.1.
AP009048 Genomic DNA. Translation: BAE76782.1.
PIRiS70891.
RefSeqiNP_417159.1. NC_000913.3.
WP_001223227.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75720; AAC75720; b2673.
BAE76782; BAE76782; BAE76782.
GeneIDi947161.
KEGGiecj:JW2648.
eco:b2673.
PATRICi32120736. VBIEscCol129921_2765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79787 Genomic DNA. Translation: CAA56184.1.
U00096 Genomic DNA. Translation: AAC75720.1.
AP009048 Genomic DNA. Translation: BAE76782.1.
PIRiS70891.
RefSeqiNP_417159.1. NC_000913.3.
WP_001223227.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H75X-ray1.70A1-81[»]
ProteinModelPortaliP0AC65.
SMRiP0AC65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260693. 11 interactors.
DIPiDIP-48164N.
IntActiP0AC65. 7 interactors.
STRINGi511145.b2673.

Proteomic databases

PaxDbiP0AC65.
PRIDEiP0AC65.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75720; AAC75720; b2673.
BAE76782; BAE76782; BAE76782.
GeneIDi947161.
KEGGiecj:JW2648.
eco:b2673.
PATRICi32120736. VBIEscCol129921_2765.

Organism-specific databases

EchoBASEiEB3071.
EcoGeneiEG13286. nrdH.

Phylogenomic databases

eggNOGiENOG4105WAZ. Bacteria.
COG0695. LUCA.
HOGENOMiHOG000095206.
InParanoidiP0AC65.
KOiK06191.
OMAiEQHWAGF.
PhylomeDBiP0AC65.

Enzyme and pathway databases

BioCyciEcoCyc:G7401-MONOMER.
ECOL316407:JW2648-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0AC65.
PROiP0AC65.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011909. GlrX_NrdH.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02194. GlrX_NrdH. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNRDH_ECOLI
AccessioniPrimary (citable) accession number: P0AC65
Secondary accession number(s): Q2MAC4, Q47414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.