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Protein

Glutaredoxin-like protein NrdH

Gene

nrdH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electron transport system for the ribonucleotide reductase system NrdEF.

GO - Molecular functioni

  • electron transfer activity Source: EcoCyc
  • protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  • cell redox homeostasis Source: EcoCyc
  • positive regulation of oxidoreductase activity Source: EcoCyc

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7401-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-like protein NrdH
Gene namesi
Name:nrdH
Synonyms:ygaN
Ordered Locus Names:b2673, JW2648
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13286 nrdH

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001416381 – 81Glutaredoxin-like protein NrdHAdd BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 14Redox-active

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0AC65
PRIDEiP0AC65

Expressioni

Inductioni

Induced 2-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260693, 13 interactors
DIPiDIP-48164N
IntActiP0AC65, 7 interactors
STRINGi316385.ECDH10B_2840

Structurei

Secondary structure

181
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi12 – 23Combined sources12
Beta strandi29 – 32Combined sources4
Turni33 – 35Combined sources3
Helixi37 – 45Combined sources9
Beta strandi53 – 56Combined sources4
Beta strandi59 – 63Combined sources5
Helixi66 – 69Combined sources4
Helixi70 – 72Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H75X-ray1.70A1-81[»]
ProteinModelPortaliP0AC65
SMRiP0AC65
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AC65

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 81GlutaredoxinPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105WAZ Bacteria
COG0695 LUCA
HOGENOMiHOG000095206
InParanoidiP0AC65
KOiK06191
OMAiACVQCDA
PhylomeDBiP0AC65

Family and domain databases

InterProiView protein in InterPro
IPR011909 GlrX_NrdH
IPR002109 Glutaredoxin
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02194 GlrX_NrdH, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0AC65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRITIYTRND CVQCHATKRA MENRGFDFEM INVDRVPEAA EALRAQGFRQ
60 70 80
LPVVIAGDLS WSGFRPDMIN RLHPAPHAAS A
Length:81
Mass (Da):9,139
Last modified:November 8, 2005 - v1
Checksum:i6D0878E9CD133137
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79787 Genomic DNA Translation: CAA56184.1
U00096 Genomic DNA Translation: AAC75720.1
AP009048 Genomic DNA Translation: BAE76782.1
PIRiS70891
RefSeqiNP_417159.1, NC_000913.3
WP_001223227.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75720; AAC75720; b2673
BAE76782; BAE76782; BAE76782
GeneIDi947161
KEGGiecj:JW2648
eco:b2673
PATRICifig|1411691.4.peg.4068

Similar proteinsi

Entry informationi

Entry nameiNRDH_ECOLI
AccessioniPrimary (citable) accession number: P0AC65
Secondary accession number(s): Q2MAC4, Q47414
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health