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P0AC64 (GLRX3_ECO57) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutaredoxin-3
Short name=Grx3
Gene names
Name:grxC
Ordered Locus Names:Z5037, ECs4488
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length83 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase By similarity.

Subunit structure

Monomer Probable.

Sequence similarities

Belongs to the glutaredoxin family.

Contains 1 glutaredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 8382Glutaredoxin-3
PRO_0000141589

Regions

Domain2 – 8382Glutaredoxin

Amino acid modifications

Disulfide bond12 ↔ 15Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P0AC64 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 5B19A85BB0C9FBEF

FASTA839,137
        10         20         30         40         50         60 
MANVEIYTKE TCPYCHRAKA LLSSKGVSFQ ELPIDGNAAK REEMIKRSGR TTVPQIFIDA 

        70         80 
QHIGGCDDLY ALDARGGLDP LLK

« Hide

References

[1]"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7."
Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J., Davis N.W. expand/collapse author list , Lim A., Dimalanta E.T., Potamousis K., Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A., Blattner F.R.
Nature 409:529-533(2001) [PubMed: 11206551] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
[2]"Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T. expand/collapse author list , Kuhara S., Shiba T., Hattori M., Shinagawa H.
DNA Res. 8:11-22(2001) [PubMed: 11258796] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005174 Genomic DNA. Translation: AAG58757.1.
BA000007 Genomic DNA. Translation: BAB37911.1.
PIRA86037.
H91189.
RefSeqNP_290193.1. NC_002655.2.
NP_312515.1. NC_002695.1.

3D structure databases

ProteinModelPortalP0AC64.
SMRP0AC64. Positions 2-83.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000025910; EBESCP00000024803; EBESCG00000024963.
EBESCT00000058930; EBESCP00000056758; EBESCG00000057978.
GeneID915569.
960937.
GenomeReviewsGene locus Z5037 in contig AE005174_GR.
Gene locus ECs4488 in contig BA000007_GR.
KEGGece:Z5037.
ecs:ECs4488.
PATRIC18358593. VBIEscCol44059_4462.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000011330.
HOGENOMHBG728471.
OMAIYTRQFC.
ProtClustDBPRK10638.

Enzyme and pathway databases

BioCycECOL83334:ECS4488-MONOMER.

Family and domain databases

InterProIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR014025. Glutaredoxin_subgr.
IPR011900. GRX_bact.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK03676.
PfamPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSPR00160. GLUTAREDOXIN.
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMsTIGR02181. GRX_bact. 1 hit.
PROSITEPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLRX3_ECO57
AccessionPrimary (citable) accession number: P0AC64
Secondary accession number(s): P37687
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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