grxB

Functionⁱ

Involved in reducing some disulfide bonds in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase.

GO - Molecular functionⁱ

electron carrier activity Source: InterPro
glutathione disulfide oxidoreductase activity
Source: EcoCyc
Inferred from direct assayⁱ
- 9111025
glutathione oxidoreductase activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

cell redox homeostasis Source: InterPro

Complete GO annotation...

Keywordsⁱ

Biological process	Electron transport, Transport

Biological process

Electron transport, Transport

Enzyme and pathway databases

BioCycⁱ	EcoCyc:GRXB-MONOMER. MetaCyc:GRXB-MONOMER.
SABIO-RKⁱ	P0AC59.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutaredoxin 2 Short name: Grx2
Gene namesⁱ	Name:grxB Ordered Locus Names:b1064, JW1051
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG12688. grxB.

EcoGeneⁱ

EG12688. grxB.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol
Source: EcoCyc
Inferred from direct assayⁱ
- 18304323
- 9111025

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000141585	1 – 215	Glutaredoxin 2Add BLAST		215

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	9 ↔ 12	Redox-activeBy similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	P0AC59.
PaxDbⁱ	P0AC59.
PRIDEⁱ	P0AC59.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	4260069. 15 interactors.
Database of interacting proteins More...DIPⁱ	DIP-48247N.
IntActⁱ	P0AC59. 1 interactor.
STRINGⁱ	316385.ECDH10B_1135.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	2 – 5	Combined sources	4
Helixⁱ	10 – 21	Combined sources	12
Beta strandⁱ	27 – 30	Combined sources	4
Helixⁱ	37 – 43	Combined sources	7
Beta strandⁱ	44 – 46	Combined sources	3
Beta strandⁱ	50 – 52	Combined sources	3
Turnⁱ	54 – 56	Combined sources	3
Beta strandⁱ	58 – 60	Combined sources	3
Helixⁱ	62 – 71	Combined sources	10
Helixⁱ	84 – 94	Combined sources	11
Turnⁱ	95 – 97	Combined sources	3
Helixⁱ	98 – 105	Combined sources	8
Helixⁱ	111 – 113	Combined sources	3
Helixⁱ	116 – 130	Combined sources	15
Helixⁱ	133 – 138	Combined sources	6
Helixⁱ	140 – 155	Combined sources	16
Beta strandⁱ	159 – 162	Combined sources	4
Helixⁱ	170 – 182	Combined sources	13
Helixⁱ	192 – 205	Combined sources	14
Helixⁱ	211 – 213	Combined sources	3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1G7O	NMR	-	A	1-215	[»]
	4KSM	X-ray	2.40	A	1-215	[»]
	4KX4	X-ray	1.60	A	1-215	[»]
ProteinModelPortalⁱ	P0AC59.
SMRⁱ	P0AC59.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P0AC59.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 77	GST N-terminalAdd BLAST		77

Sequence similaritiesⁱ

Belongs to the glutaredoxin family.Curated

Keywords - Domainⁱ

Redox-active center

Phylogenomic databases

eggNOGⁱ	ENOG4105E9S. Bacteria. COG2999. LUCA.
HOGENOMⁱ	HOG000064700.
InParanoidⁱ	P0AC59.
KEGG Orthology (KO) More...KOⁱ	K03675.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03199. GST_C_GRX2. 1 hit.
InterProⁱ	View protein in InterPro IPR011767. GLR_AS. IPR007494. Glutaredoxin2_C. IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR011901. Grx2. IPR012336. Thioredoxin-like_fold.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04399. Glutaredoxin2_C. 1 hit. PF13417. GST_N_3. 1 hit.
SFLDⁱ	SFLDG01183. Grx2-like. 1 hit.
SUPFAMⁱ	SSF47616. SSF47616. 1 hit. SSF52833. SSF52833. 1 hit.
TIGRFAMsⁱ	TIGR02182. GRXB. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00195. GLUTAREDOXIN_1. 1 hit. PS50404. GST_NTER. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P0AC59-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLYIYDHCP YCLKARMIFG LKNIPVELHV LLNDDAETPT RMVGQKQVPI 
        60         70         80         90        100
LQKDDSRYMP ESMDIVHYVD KLDGKPLLTG KRSPAIEEWL RKVNGYANKL 
       110        120        130        140        150
LLPRFAKSAF DEFSTPAARK YFVDKKEASA GNFADLLAHS DGLIKNISDD 
       160        170        180        190        200
LRALDKLIVK PNAVNGELSE DDIQLFPLLR NLTLVAGINW PSRVADYRDN 
       210 
MAKQTQINLL SSMAI

Length:215

Mass (Da):24,350

Last modified:November 8, 2005 - v1

Checksum:ⁱA8AAAB2548D824FE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	13	L → I AA sequence (PubMed:7937896).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X92076 Genomic DNA. Translation: CAA63058.1. U00096 Genomic DNA. Translation: AAC74148.1. AP009048 Genomic DNA. Translation: BAA35872.1.
PIRⁱ	E64849.
NCBI Reference Sequences More...RefSeqⁱ	NP_415582.1. NC_000913.3. WP_000780912.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAC74148; AAC74148; b1064. BAA35872; BAA35872; BAA35872.
GeneIDⁱ	946926.
KEGGⁱ	ecj:JW1051. eco:b1064.
PATRICⁱ	fig\|1411691.4.peg.1204.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X92076 Genomic DNA. Translation: CAA63058.1. U00096 Genomic DNA. Translation: AAC74148.1. AP009048 Genomic DNA. Translation: BAA35872.1.
PIRⁱ	E64849.
NCBI Reference Sequences More...RefSeqⁱ	NP_415582.1. NC_000913.3. WP_000780912.1. NZ_LN832404.1.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1G7O	NMR	-	A	1-215	[»]
	4KSM	X-ray	2.40	A	1-215	[»]
	4KX4	X-ray	1.60	A	1-215	[»]
ProteinModelPortalⁱ	P0AC59.
SMRⁱ	P0AC59.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4260069. 15 interactors.
Database of interacting proteins More...DIPⁱ	DIP-48247N.
IntActⁱ	P0AC59. 1 interactor.
STRINGⁱ	316385.ECDH10B_1135.

Proteomic databases

EPDⁱ	P0AC59.
PaxDbⁱ	P0AC59.
PRIDEⁱ	P0AC59.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC74148; AAC74148; b1064. BAA35872; BAA35872; BAA35872.
GeneIDⁱ	946926.
KEGGⁱ	ecj:JW1051. eco:b1064.
PATRICⁱ	fig\|1411691.4.peg.1204.

Organism-specific databases

EchoBASEⁱ	EB2551.
EcoGeneⁱ	EG12688. grxB.

Phylogenomic databases

eggNOGⁱ	ENOG4105E9S. Bacteria. COG2999. LUCA.
HOGENOMⁱ	HOG000064700.
InParanoidⁱ	P0AC59.
KEGG Orthology (KO) More...KOⁱ	K03675.

Enzyme and pathway databases

BioCycⁱ	EcoCyc:GRXB-MONOMER. MetaCyc:GRXB-MONOMER.
SABIO-RKⁱ	P0AC59.

Miscellaneous databases

EvolutionaryTraceⁱ	P0AC59.
Protein Ontology More...PROⁱ	PR:P0AC59.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03199. GST_C_GRX2. 1 hit.
InterProⁱ	View protein in InterPro IPR011767. GLR_AS. IPR007494. Glutaredoxin2_C. IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR011901. Grx2. IPR012336. Thioredoxin-like_fold.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04399. Glutaredoxin2_C. 1 hit. PF13417. GST_N_3. 1 hit.
SFLDⁱ	SFLDG01183. Grx2-like. 1 hit.
SUPFAMⁱ	SSF47616. SSF47616. 1 hit. SSF52833. SSF52833. 1 hit.
TIGRFAMsⁱ	TIGR02182. GRXB. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00195. GLUTAREDOXIN_1. 1 hit. PS50404. GST_NTER. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLRX2_ECOLI
Accessionⁱ	P0AC59Primary (citable) accession number: P0AC59 Secondary accession number(s): P39811, P75928, P77043
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	November 8, 2005
	Last modified:	July 5, 2017
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0AC59 (GLRX2_ECOLI)

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Glutaredoxin 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ