UniProtKB - P0AC59 (GLRX2_ECOLI)
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Protein
Glutaredoxin 2
Gene
grxB
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in reducing some disulfide bonds in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase.
GO - Molecular functioni
- electron transfer activity Source: InterPro
- glutathione disulfide oxidoreductase activity Source: EcoCyc
- glutathione oxidoreductase activity Source: InterPro
GO - Biological processi
- cell redox homeostasis Source: InterPro
Keywordsi
Biological process | Electron transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:GRXB-MONOMER. MetaCyc:GRXB-MONOMER. |
SABIO-RKi | P0AC59. |
Names & Taxonomyi
Protein namesi | Recommended name: Glutaredoxin 2Short name: Grx2 |
Gene namesi | Name:grxB Ordered Locus Names:b1064, JW1051 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Organism-specific databases
EcoGenei | EG12688. grxB. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000141585 | 1 – 215 | Glutaredoxin 2Add BLAST | 215 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 9 ↔ 12 | Redox-activeBy similarity |
Keywords - PTMi
Disulfide bondProteomic databases
EPDi | P0AC59. |
PaxDbi | P0AC59. |
PRIDEi | P0AC59. |
Interactioni
Protein-protein interaction databases
BioGridi | 4260069. 19 interactors. |
DIPi | DIP-48247N. |
IntActi | P0AC59. 1 interactor. |
STRINGi | 316385.ECDH10B_1135. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 2 – 5 | Combined sources | 4 | |
Helixi | 10 – 21 | Combined sources | 12 | |
Beta strandi | 27 – 30 | Combined sources | 4 | |
Helixi | 37 – 43 | Combined sources | 7 | |
Beta strandi | 44 – 46 | Combined sources | 3 | |
Beta strandi | 50 – 52 | Combined sources | 3 | |
Turni | 54 – 56 | Combined sources | 3 | |
Beta strandi | 58 – 60 | Combined sources | 3 | |
Helixi | 62 – 71 | Combined sources | 10 | |
Helixi | 84 – 94 | Combined sources | 11 | |
Turni | 95 – 97 | Combined sources | 3 | |
Helixi | 98 – 105 | Combined sources | 8 | |
Helixi | 111 – 113 | Combined sources | 3 | |
Helixi | 116 – 130 | Combined sources | 15 | |
Helixi | 133 – 138 | Combined sources | 6 | |
Helixi | 140 – 155 | Combined sources | 16 | |
Beta strandi | 159 – 162 | Combined sources | 4 | |
Helixi | 170 – 182 | Combined sources | 13 | |
Helixi | 192 – 205 | Combined sources | 14 | |
Helixi | 211 – 213 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1G7O | NMR | - | A | 1-215 | [»] | |
4KSM | X-ray | 2.40 | A | 1-215 | [»] | |
4KX4 | X-ray | 1.60 | A | 1-215 | [»] | |
ProteinModelPortali | P0AC59. | |||||
SMRi | P0AC59. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0AC59. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 77 | GST N-terminalAdd BLAST | 77 |
Sequence similaritiesi
Belongs to the glutaredoxin family.Curated
Keywords - Domaini
Redox-active centerPhylogenomic databases
eggNOGi | ENOG4105E9S. Bacteria. COG2999. LUCA. |
HOGENOMi | HOG000064700. |
InParanoidi | P0AC59. |
KOi | K03675. |
OMAi | LRNLTCV. |
Family and domain databases
CDDi | cd03199. GST_C_GRX2. 1 hit. |
InterProi | View protein in InterPro IPR011767. GLR_AS. IPR007494. Glutaredoxin2_C. IPR036282. Glutathione-S-Trfase_C_sf. IPR004045. Glutathione_S-Trfase_N. IPR011901. Grx2. IPR036249. Thioredoxin-like_sf. |
Pfami | View protein in Pfam PF04399. Glutaredoxin2_C. 1 hit. PF13417. GST_N_3. 1 hit. |
SFLDi | SFLDG01183. Grx2-like. 1 hit. |
SUPFAMi | SSF47616. SSF47616. 1 hit. SSF52833. SSF52833. 1 hit. |
TIGRFAMsi | TIGR02182. GRXB. 1 hit. |
PROSITEi | View protein in PROSITE PS00195. GLUTAREDOXIN_1. 1 hit. PS50404. GST_NTER. 1 hit. |
i Sequence
Sequence statusi: Complete.
P0AC59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLYIYDHCP YCLKARMIFG LKNIPVELHV LLNDDAETPT RMVGQKQVPI
60 70 80 90 100
LQKDDSRYMP ESMDIVHYVD KLDGKPLLTG KRSPAIEEWL RKVNGYANKL
110 120 130 140 150
LLPRFAKSAF DEFSTPAARK YFVDKKEASA GNFADLLAHS DGLIKNISDD
160 170 180 190 200
LRALDKLIVK PNAVNGELSE DDIQLFPLLR NLTLVAGINW PSRVADYRDN
210
MAKQTQINLL SSMAI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | L → I AA sequence (PubMed:7937896).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92076 Genomic DNA. Translation: CAA63058.1. U00096 Genomic DNA. Translation: AAC74148.1. AP009048 Genomic DNA. Translation: BAA35872.1. |
PIRi | E64849. |
RefSeqi | NP_415582.1. NC_000913.3. WP_000780912.1. NZ_LN832404.1. |
Genome annotation databases
EnsemblBacteriai | AAC74148; AAC74148; b1064. BAA35872; BAA35872; BAA35872. |
GeneIDi | 946926. |
KEGGi | ecj:JW1051. eco:b1064. |
PATRICi | fig|1411691.4.peg.1204. |
Similar proteinsi
Entry informationi
Entry namei | GLRX2_ECOLI | |
Accessioni | P0AC59Primary (citable) accession number: P0AC59 Secondary accession number(s): P39811, P75928, P77043 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | March 28, 2018 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |