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P0AC54

- G6PD_ECOL6

UniProt

P0AC54 - G6PD_ECOL6

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei50 – 501NADPUniRule annotation
    Binding sitei147 – 1471NADPUniRule annotation
    Binding sitei177 – 1771SubstrateUniRule annotation
    Binding sitei181 – 1811SubstrateUniRule annotation
    Binding sitei215 – 2151SubstrateUniRule annotation
    Binding sitei234 – 2341SubstrateUniRule annotation
    Active sitei239 – 2391Proton acceptorUniRule annotation
    Binding sitei339 – 3391SubstrateUniRule annotation
    Binding sitei344 – 3441SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi92 – 932NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciECOL199310:C2265-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:c2265
    OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
    Taxonomic identifieri199310 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001410: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Glucose-6-phosphate 1-dehydrogenasePRO_0000068120Add
    BLAST

    Proteomic databases

    PRIDEiP0AC54.

    Interactioni

    Protein-protein interaction databases

    STRINGi199310.c2265.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AC54.
    SMRiP0AC54. Positions 12-480.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000046191.
    KOiK00036.
    OMAiYCVTAVS.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0AC54-1 [UniParc]FASTAAdd to Basket

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    MAVTQTAQAC DLVIFGAKGD LARRKLLPSL YQLEKAGQLN PDTRIIGVGR    50
    ADWDKAAYTK VVREALETFM KETIDEGLWD TLSARLDFCN LDVNDTAAFS 100
    RLGAMLDQKN RITINYFAMP PSTFGAICKG LGEAKLNAKP ARVVMEKPLG 150
    TSLATSQEIN DQVGEYFEEC QVYRIDHYLG KETVLNLLAL RFANSLFVNN 200
    WDNRTIDHVE ITVAEEVGIE GRWGYFDKAG QMRDMIQNHL LQILCMIAMS 250
    PPSDLSADSI RDEKVKVLKS LRRIDRSNVR EKTVRGQYTA GFAQGKKVPG 300
    YLEEEGANKS SNTETFVAIR VDIDNWRWAG VPFYLRTGKR LPTKCSEVVV 350
    YFKTPELNLF KESWQDLPQN KLTIRLQPDE GVDIQVLNKV PGLDHKHNLQ 400
    ITKLDLSYSE TFNQTHLADA YERLLLETMR GIQALFVRRD EVEEAWKWVD 450
    SITEAWAMDN DAPKPYQAGT WGPVASVAMI TRDGRSWNEF E 491
    Length:491
    Mass (Da):55,704
    Last modified:November 8, 2005 - v1
    Checksum:i263F07D298EAFCD3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80722.1.
    RefSeqiNP_754157.1. NC_004431.1.

    Genome annotation databases

    EnsemblBacteriaiAAN80722; AAN80722; c2265.
    GeneIDi1036807.
    KEGGiecc:c2265.
    PATRICi18282411. VBIEscCol75197_2122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014075 Genomic DNA. Translation: AAN80722.1 .
    RefSeqi NP_754157.1. NC_004431.1.

    3D structure databases

    ProteinModelPortali P0AC54.
    SMRi P0AC54. Positions 12-480.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 199310.c2265.

    Proteomic databases

    PRIDEi P0AC54.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN80722 ; AAN80722 ; c2265 .
    GeneIDi 1036807.
    KEGGi ecc:c2265.
    PATRICi 18282411. VBIEscCol75197_2122.

    Phylogenomic databases

    HOGENOMi HOG000046191.
    KOi K00036.
    OMAi YCVTAVS.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci ECOL199310:C2265-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CFT073 / ATCC 700928 / UPEC.

    Entry informationi

    Entry nameiG6PD_ECOL6
    AccessioniPrimary (citable) accession number: P0AC54
    Secondary accession number(s): P22992
    , P78069, Q60134, Q60139
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3