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P0AC54

- G6PD_ECOL6

UniProt

P0AC54 - G6PD_ECOL6

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Protein
Glucose-6-phosphate 1-dehydrogenase
Gene
zwf, c2265
Organism
Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501NADP By similarity
Binding sitei147 – 1471NADP By similarity
Binding sitei177 – 1771Substrate By similarity
Binding sitei181 – 1811Substrate By similarity
Binding sitei215 – 2151Substrate By similarity
Binding sitei234 – 2341Substrate By similarity
Active sitei239 – 2391Proton acceptor By similarity
Binding sitei339 – 3391Substrate By similarity
Binding sitei344 – 3441Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi92 – 932NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: UniProtKB-HAMAP
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciECOL199310:C2265-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:c2265
OrganismiEscherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
Taxonomic identifieri199310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001410: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Glucose-6-phosphate 1-dehydrogenaseUniRule annotation
PRO_0000068120Add
BLAST

Proteomic databases

PRIDEiP0AC54.

Interactioni

Protein-protein interaction databases

STRINGi199310.c2265.

Structurei

3D structure databases

ProteinModelPortaliP0AC54.
SMRiP0AC54. Positions 12-480.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000046191.
KOiK00036.
OMAiYCVTAVS.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AC54-1 [UniParc]FASTAAdd to Basket

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MAVTQTAQAC DLVIFGAKGD LARRKLLPSL YQLEKAGQLN PDTRIIGVGR    50
ADWDKAAYTK VVREALETFM KETIDEGLWD TLSARLDFCN LDVNDTAAFS 100
RLGAMLDQKN RITINYFAMP PSTFGAICKG LGEAKLNAKP ARVVMEKPLG 150
TSLATSQEIN DQVGEYFEEC QVYRIDHYLG KETVLNLLAL RFANSLFVNN 200
WDNRTIDHVE ITVAEEVGIE GRWGYFDKAG QMRDMIQNHL LQILCMIAMS 250
PPSDLSADSI RDEKVKVLKS LRRIDRSNVR EKTVRGQYTA GFAQGKKVPG 300
YLEEEGANKS SNTETFVAIR VDIDNWRWAG VPFYLRTGKR LPTKCSEVVV 350
YFKTPELNLF KESWQDLPQN KLTIRLQPDE GVDIQVLNKV PGLDHKHNLQ 400
ITKLDLSYSE TFNQTHLADA YERLLLETMR GIQALFVRRD EVEEAWKWVD 450
SITEAWAMDN DAPKPYQAGT WGPVASVAMI TRDGRSWNEF E 491
Length:491
Mass (Da):55,704
Last modified:November 8, 2005 - v1
Checksum:i263F07D298EAFCD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80722.1.
RefSeqiNP_754157.1. NC_004431.1.

Genome annotation databases

EnsemblBacteriaiAAN80722; AAN80722; c2265.
GeneIDi1036807.
KEGGiecc:c2265.
PATRICi18282411. VBIEscCol75197_2122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014075 Genomic DNA. Translation: AAN80722.1 .
RefSeqi NP_754157.1. NC_004431.1.

3D structure databases

ProteinModelPortali P0AC54.
SMRi P0AC54. Positions 12-480.
ModBasei Search...

Protein-protein interaction databases

STRINGi 199310.c2265.

Proteomic databases

PRIDEi P0AC54.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN80722 ; AAN80722 ; c2265 .
GeneIDi 1036807.
KEGGi ecc:c2265.
PATRICi 18282411. VBIEscCol75197_2122.

Phylogenomic databases

HOGENOMi HOG000046191.
KOi K00036.
OMAi YCVTAVS.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci ECOL199310:C2265-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CFT073 / ATCC 700928 / UPEC.

Entry informationi

Entry nameiG6PD_ECOL6
AccessioniPrimary (citable) accession number: P0AC54
Secondary accession number(s): P22992
, P78069, Q60134, Q60139
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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