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Protein

Succinate dehydrogenase hydrophobic membrane anchor subunit

Gene

sdhD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH).

Cofactori

hemeNote: The heme is bound between the two transmembrane subunits.

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Iron (heme axial ligand); shared with second transmembrane subunit1
Binding sitei83Ubiquinone1 Publication1

GO - Molecular functioni

  • electron carrier activity Source: EcoCyc
  • heme binding Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW
  • succinate dehydrogenase activity Source: InterPro

GO - Biological processi

  • aerobic respiration Source: EcoCyc
  • cytochrome complex assembly Source: EcoCyc
  • tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:SDH-MEMB2.
ECOL316407:JW0712-MONOMER.
MetaCyc:SDH-MEMB2.
UniPathwayiUPA00223.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase hydrophobic membrane anchor subunit
Gene namesi
Name:sdhD
Ordered Locus Names:b0722, JW0712
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10934. sdhD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicCuratedAdd BLAST15
Transmembranei16 – 36HelicalAdd BLAST21
Topological domaini37 – 58PeriplasmicCuratedAdd BLAST22
Transmembranei59 – 80HelicalAdd BLAST22
Topological domaini81 – 90CytoplasmicCurated10
Transmembranei91 – 115HelicalAdd BLAST25

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586721 – 115Succinate dehydrogenase hydrophobic membrane anchor subunitAdd BLAST115

Proteomic databases

PaxDbiP0AC44.
PRIDEiP0AC44.

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.3 Publications

Protein-protein interaction databases

BioGridi4259943. 6 interactors.
DIPiDIP-10838N.
IntActiP0AC44. 1 interactor.
STRINGi511145.b0722.

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Helixi12 – 37Combined sources26
Turni38 – 40Combined sources3
Helixi45 – 53Combined sources9
Helixi55 – 83Combined sources29
Helixi87 – 112Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NEKX-ray2.60D1-115[»]
1NENX-ray2.90D1-115[»]
2ACZX-ray3.10D1-115[»]
2AD0model-D1-115[»]
2WDQX-ray2.40D/H/L1-115[»]
2WDRX-ray3.20D/H/L1-115[»]
2WDVX-ray3.20D/H/L1-115[»]
2WP9X-ray2.70D/H/L1-115[»]
2WS3X-ray3.20D/H/L1-115[»]
2WU2X-ray2.50D/H/L1-115[»]
2WU5X-ray2.80D/H/L1-115[»]
ProteinModelPortaliP0AC44.
SMRiP0AC44.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AC44.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105N1I. Bacteria.
COG2142. LUCA.
HOGENOMiHOG000160364.
InParanoidiP0AC44.
KOiK00242.
OMAiQWMKVLT.
PhylomeDBiP0AC44.

Family and domain databases

InterProiIPR014312. Succ_DH_anchor.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view]
PfamiPF01127. Sdh_cyt. 1 hit.
[Graphical view]
PIRSFiPIRSF000169. SDH_D. 1 hit.
TIGRFAMsiTIGR02968. succ_dehyd_anc. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AC44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSNASALGR NGVHDFILVR ATAIVLTLYI IYMVGFFATS GELTYEVWIG
60 70 80 90 100
FFASAFTKVF TLLALFSILI HAWIGMWQVL TDYVKPLALR LMLQLVIVVA
110
LVVYVIYGFV VVWGV
Length:115
Mass (Da):12,868
Last modified:November 8, 2005 - v1
Checksum:i5CFD0104CB3CC2F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01619 Genomic DNA. Translation: AAA23894.1.
X00980 Genomic DNA. Translation: CAA25486.1.
U00096 Genomic DNA. Translation: AAC73816.1.
AP009048 Genomic DNA. Translation: BAA35389.1.
PIRiB28836. DEECS2.
RefSeqiNP_415250.1. NC_000913.3.
WP_000254365.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73816; AAC73816; b0722.
BAA35389; BAA35389; BAA35389.
GeneIDi945322.
KEGGiecj:JW0712.
eco:b0722.
PATRICi32116639. VBIEscCol129921_0752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01619 Genomic DNA. Translation: AAA23894.1.
X00980 Genomic DNA. Translation: CAA25486.1.
U00096 Genomic DNA. Translation: AAC73816.1.
AP009048 Genomic DNA. Translation: BAA35389.1.
PIRiB28836. DEECS2.
RefSeqiNP_415250.1. NC_000913.3.
WP_000254365.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NEKX-ray2.60D1-115[»]
1NENX-ray2.90D1-115[»]
2ACZX-ray3.10D1-115[»]
2AD0model-D1-115[»]
2WDQX-ray2.40D/H/L1-115[»]
2WDRX-ray3.20D/H/L1-115[»]
2WDVX-ray3.20D/H/L1-115[»]
2WP9X-ray2.70D/H/L1-115[»]
2WS3X-ray3.20D/H/L1-115[»]
2WU2X-ray2.50D/H/L1-115[»]
2WU5X-ray2.80D/H/L1-115[»]
ProteinModelPortaliP0AC44.
SMRiP0AC44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259943. 6 interactors.
DIPiDIP-10838N.
IntActiP0AC44. 1 interactor.
STRINGi511145.b0722.

Proteomic databases

PaxDbiP0AC44.
PRIDEiP0AC44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73816; AAC73816; b0722.
BAA35389; BAA35389; BAA35389.
GeneIDi945322.
KEGGiecj:JW0712.
eco:b0722.
PATRICi32116639. VBIEscCol129921_0752.

Organism-specific databases

EchoBASEiEB0927.
EcoGeneiEG10934. sdhD.

Phylogenomic databases

eggNOGiENOG4105N1I. Bacteria.
COG2142. LUCA.
HOGENOMiHOG000160364.
InParanoidiP0AC44.
KOiK00242.
OMAiQWMKVLT.
PhylomeDBiP0AC44.

Enzyme and pathway databases

UniPathwayiUPA00223.
BioCyciEcoCyc:SDH-MEMB2.
ECOL316407:JW0712-MONOMER.
MetaCyc:SDH-MEMB2.

Miscellaneous databases

EvolutionaryTraceiP0AC44.
PROiP0AC44.

Family and domain databases

InterProiIPR014312. Succ_DH_anchor.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view]
PfamiPF01127. Sdh_cyt. 1 hit.
[Graphical view]
PIRSFiPIRSF000169. SDH_D. 1 hit.
TIGRFAMsiTIGR02968. succ_dehyd_anc. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHSD_ECOLI
AccessioniPrimary (citable) accession number: P0AC44
Secondary accession number(s): P10445
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.