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Protein

Succinate dehydrogenase hydrophobic membrane anchor subunit

Gene

sdhD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH).

Cofactori

hemeNote: The heme is bound between the two transmembrane subunits.

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Iron (heme axial ligand); shared with second transmembrane subunit1
Binding sitei83Ubiquinone1 Publication1

GO - Molecular functioni

  • electron transfer activity Source: EcoCyc
  • heme binding Source: EcoCyc
  • metal ion binding Source: UniProtKB-KW
  • succinate dehydrogenase activity Source: InterPro

GO - Biological processi

  • aerobic respiration Source: EcoCyc
  • cytochrome complex assembly Source: EcoCyc
  • tricarboxylic acid cycle Source: UniProtKB-UniPathway

Keywordsi

Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:SDH-MEMB2
MetaCyc:SDH-MEMB2
UniPathwayiUPA00223

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase hydrophobic membrane anchor subunit
Gene namesi
Name:sdhD
Ordered Locus Names:b0722, JW0712
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10934 sdhD

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicCuratedAdd BLAST15
Transmembranei16 – 36HelicalAdd BLAST21
Topological domaini37 – 58PeriplasmicCuratedAdd BLAST22
Transmembranei59 – 80HelicalAdd BLAST22
Topological domaini81 – 90CytoplasmicCurated10
Transmembranei91 – 115HelicalAdd BLAST25

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB04631 Atpenin A5
DB08690 UBIQUINONE-2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586721 – 115Succinate dehydrogenase hydrophobic membrane anchor subunitAdd BLAST115

Proteomic databases

PaxDbiP0AC44
PRIDEiP0AC44

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.3 Publications

Protein-protein interaction databases

BioGridi4259943, 25 interactors
ComplexPortaliCPX-1931 Respiratory chain complex II
DIPiDIP-10838N
IntActiP0AC44, 1 interactor
STRINGi316385.ECDH10B_0789

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Helixi12 – 37Combined sources26
Turni38 – 40Combined sources3
Helixi45 – 53Combined sources9
Helixi55 – 83Combined sources29
Helixi87 – 112Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NEKX-ray2.60D1-115[»]
1NENX-ray2.90D1-115[»]
2ACZX-ray3.10D1-115[»]
2AD0model-D1-115[»]
2WDQX-ray2.40D/H/L1-115[»]
2WDRX-ray3.20D/H/L1-115[»]
2WDVX-ray3.20D/H/L1-115[»]
2WP9X-ray2.70D/H/L1-115[»]
2WS3X-ray3.20D/H/L1-115[»]
2WU2X-ray2.50D/H/L1-115[»]
2WU5X-ray2.80D/H/L1-115[»]
ProteinModelPortaliP0AC44
SMRiP0AC44
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AC44

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105N1I Bacteria
COG2142 LUCA
HOGENOMiHOG000160364
InParanoidiP0AC44
KOiK00242
OMAiQWMKVLT
PhylomeDBiP0AC44

Family and domain databases

Gene3Di1.20.1300.10, 1 hit
InterProiView protein in InterPro
IPR034804 SQR/QFR_C/D
IPR014312 Succ_DH_anchor
IPR000701 SuccDH_FuR_B_TM-su
PANTHERiPTHR38689 PTHR38689, 1 hit
PfamiView protein in Pfam
PF01127 Sdh_cyt, 1 hit
PIRSFiPIRSF000169 SDH_D, 1 hit
SUPFAMiSSF81343 SSF81343, 1 hit
TIGRFAMsiTIGR02968 succ_dehyd_anc, 1 hit

Sequencei

Sequence statusi: Complete.

P0AC44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSNASALGR NGVHDFILVR ATAIVLTLYI IYMVGFFATS GELTYEVWIG
60 70 80 90 100
FFASAFTKVF TLLALFSILI HAWIGMWQVL TDYVKPLALR LMLQLVIVVA
110
LVVYVIYGFV VVWGV
Length:115
Mass (Da):12,868
Last modified:November 8, 2005 - v1
Checksum:i5CFD0104CB3CC2F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01619 Genomic DNA Translation: AAA23894.1
X00980 Genomic DNA Translation: CAA25486.1
U00096 Genomic DNA Translation: AAC73816.1
AP009048 Genomic DNA Translation: BAA35389.1
PIRiB28836 DEECS2
RefSeqiNP_415250.1, NC_000913.3
WP_000254365.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73816; AAC73816; b0722
BAA35389; BAA35389; BAA35389
GeneIDi945322
KEGGiecj:JW0712
eco:b0722
PATRICifig|1411691.4.peg.1550

Similar proteinsi

Entry informationi

Entry nameiDHSD_ECOLI
AccessioniPrimary (citable) accession number: P0AC44
Secondary accession number(s): P10445
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 20, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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