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Protein

Aspartate ammonia-lyase

Gene

aspA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-aspartate = fumarate + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate ammonia-lyase (EC:4.3.1.1)
Short name:
Aspartase
Gene namesi
Name:aspA
Ordered Locus Names:SF4293, S4560
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Aspartate ammonia-lyasePRO_0000161346Add
BLAST

Proteomic databases

PaxDbiP0AC40.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi198214.SF4293.

Structurei

3D structure databases

ProteinModelPortaliP0AC40.
SMRiP0AC40. Positions 1-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni143 – 1453Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108IJ0. Bacteria.
COG1027. LUCA.
HOGENOMiHOG000061737.
KOiK01744.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AC40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNIRIEED LLGTREVPAD AYYGVHTLRA IENFYISNNK ISDIPEFVRG
60 70 80 90 100
MVMVKKAAAM ANKELQTIPK SVANAIIAAC DEVLNNGKCM DQFPVDVYQG
110 120 130 140 150
GAGTSVNMNT NEVLANIGLE LMGHQKGEYQ YLNPNDHVNK CQSTNDAYPT
160 170 180 190 200
GFRIAVYSSL IKLVDAINQL REGFERKAVE FQDILKMGRT QLQDAVPMTL
210 220 230 240 250
GQEFRAFSIL LKEEVKNIQR TAELLLEVNL GATAIGTGLN TPKEYSPLAV
260 270 280 290 300
KKLAEVTGFP CVPAEDLIEA TSDCGAYVMV HGALKRLAVK MSKICNDLRL
310 320 330 340 350
LSSGPRAGLN EINLPELQAG SSIMPAKVNP VVPEVVNQVC FKVIGNDTTV
360 370 380 390 400
TMAAEAGQLQ LNVMEPVIGQ AMFESVHILT NACYNLLEKC INGITANKEV
410 420 430 440 450
CEGYVYNSIG IVTYLNPFIG HHNGDIVGKI CAETGKSVRE VVLERGLLTE
460 470
AELDDIFSVQ NLMHPAYKAK RYTDESEQ
Length:478
Mass (Da):52,356
Last modified:August 13, 1987 - v1
Checksum:iB6E8432DBF385DEA
GO

Sequence cautioni

The sequence AAN45711 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP19497 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN45711.2. Different initiation.
AE014073 Genomic DNA. Translation: AAP19497.1. Different initiation.
RefSeqiNP_710004.2. NC_004337.2.
WP_000069437.1. NZ_LM651928.1.

Genome annotation databases

EnsemblBacteriaiAAN45711; AAN45711; SF4293.
AAP19497; AAP19497; S4560.
GeneIDi1026585.
KEGGisfl:SF4293.
sft:NCTC1_04662.
sfx:S4560.
PATRICi18711148. VBIShiFle31049_4976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN45711.2. Different initiation.
AE014073 Genomic DNA. Translation: AAP19497.1. Different initiation.
RefSeqiNP_710004.2. NC_004337.2.
WP_000069437.1. NZ_LM651928.1.

3D structure databases

ProteinModelPortaliP0AC40.
SMRiP0AC40. Positions 1-460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF4293.

Proteomic databases

PaxDbiP0AC40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN45711; AAN45711; SF4293.
AAP19497; AAP19497; S4560.
GeneIDi1026585.
KEGGisfl:SF4293.
sft:NCTC1_04662.
sfx:S4560.
PATRICi18711148. VBIShiFle31049_4976.

Phylogenomic databases

eggNOGiENOG4108IJ0. Bacteria.
COG1027. LUCA.
HOGENOMiHOG000061737.
KOiK01744.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR004708. ApsA.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00839. aspA. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASPA_SHIFL
AccessioniPrimary (citable) accession number: P0AC40
Secondary accession number(s): P04422, P78140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.