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Protein

L(+)-tartrate dehydratase subunit beta

Gene

ttdB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R,R)-tartrate = oxaloacetate + H2O.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Sequence analysis1

GO - Molecular functioni

GO - Biological processi

  • response to heat Source: EcoCyc

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciEcoCyc:TTDB-MONOMER
MetaCyc:TTDB-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
L(+)-tartrate dehydratase subunit beta (EC:4.2.1.32)
Short name:
L-TTD beta
Gene namesi
Name:ttdB
Synonyms:ygjB
Ordered Locus Names:b3062, JW3034
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11169 ttdB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001956641 – 201L(+)-tartrate dehydratase subunit betaAdd BLAST201

Proteomic databases

PaxDbiP0AC35
PRIDEiP0AC35

Expressioni

Inductioni

Induced by tartrate, via TtdR.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.1 Publication

Protein-protein interaction databases

BioGridi4261199, 429 interactors
IntActiP0AC35, 2 interactors
STRINGi316385.ECDH10B_3237

Structurei

3D structure databases

ProteinModelPortaliP0AC35
SMRiP0AC35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I fumarase family.Curated

Phylogenomic databases

eggNOGiENOG4107GFK Bacteria
COG1838 LUCA
HOGENOMiHOG000225718
InParanoidiP0AC35
KOiK03780
OMAiIYHAGPI
PhylomeDBiP0AC35

Family and domain databases

Gene3Di3.20.130.10, 1 hit
InterProiView protein in InterPro
IPR004647 Fe-S_hydro-lyase_TtdB-typ_cat
IPR036660 Fe-S_hydroAse_TtdB_cat_sf
PfamiView protein in Pfam
PF05683 Fumerase_C, 1 hit
SUPFAMiSSF117457 SSF117457, 1 hit
TIGRFAMsiTIGR00723 ttdB_fumA_fumB, 1 hit

Sequencei

Sequence statusi: Complete.

P0AC35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILTTPIK AEDLQDIRVG DVIYLTGTLV TCRDVCHRRL IELKRPIPYD
60 70 80 90 100
LNGKAIFHAG PIVRKNGDKW EMVSVGPTTS MRMESFEREF IEQTGVKLVV
110 120 130 140 150
GKGGMGPLTE EGCQKFKALH VIFPAGCAVL AATQVEEIEE VHWTELGMPE
160 170 180 190 200
SLWVCRVKEF GPLIVSIDTH GNNLIAENKK LFAERRDPIV EEICEHVHYI

K
Length:201
Mass (Da):22,679
Last modified:November 8, 2005 - v1
Checksum:iE81321CD19A8BE5C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80 – 85SMRMES → QYAYGK (PubMed:8371115).Curated6
Sequence conflicti80 – 85SMRMES → QYAYGK (PubMed:3297921).Curated6
Sequence conflicti165V → A (PubMed:8371115).Curated1
Sequence conflicti165V → A (PubMed:3297921).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14781 Unassigned DNA Translation: AAA03062.1
M16194 Genomic DNA Translation: AAA72574.1
U28379 Genomic DNA Translation: AAA89142.1
U00096 Genomic DNA Translation: AAC76098.1
AP009048 Genomic DNA Translation: BAE77113.1
PIRiD65094 QQECRZ
RefSeqiNP_417534.1, NC_000913.3
WP_000722957.1, NZ_CP014272.1

Genome annotation databases

EnsemblBacteriaiAAC76098; AAC76098; b3062
BAE77113; BAE77113; BAE77113
GeneIDi947568
KEGGiecj:JW3034
eco:b3062
PATRICifig|511145.12.peg.3156

Similar proteinsi

Entry informationi

Entry nameiTTDB_ECOLI
AccessioniPrimary (citable) accession number: P0AC35
Secondary accession number(s): P05851, P33131, Q2M9E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health