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Protein

L(+)-tartrate dehydratase subunit beta

Gene

ttdB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(R,R)-tartrate = oxaloacetate + H2O.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Sequence analysis

GO - Molecular functioni

GO - Biological processi

  • response to heat Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciEcoCyc:TTDB-MONOMER.
ECOL316407:JW3034-MONOMER.
MetaCyc:TTDB-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L(+)-tartrate dehydratase subunit beta (EC:4.2.1.32)
Short name:
L-TTD beta
Gene namesi
Name:ttdB
Synonyms:ygjB
Ordered Locus Names:b3062, JW3034
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11169. ttdB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201L(+)-tartrate dehydratase subunit betaPRO_0000195664Add
BLAST

Proteomic databases

PaxDbiP0AC35.

Expressioni

Inductioni

Induced by tartrate, via TtdR.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.1 Publication

Protein-protein interaction databases

BioGridi4261199. 429 interactions.
IntActiP0AC35. 2 interactions.
STRINGi511145.b3062.

Structurei

3D structure databases

ProteinModelPortaliP0AC35.
SMRiP0AC35. Positions 1-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I fumarase family.Curated

Phylogenomic databases

eggNOGiENOG4107GFK. Bacteria.
COG1838. LUCA.
HOGENOMiHOG000225718.
InParanoidiP0AC35.
KOiK03780.
OMAiIYHAGPI.
OrthoDBiEOG6TXR10.
PhylomeDBiP0AC35.

Family and domain databases

Gene3Di3.20.130.10. 1 hit.
InterProiIPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
[Graphical view]
PfamiPF05683. Fumerase_C. 1 hit.
[Graphical view]
SUPFAMiSSF117457. SSF117457. 1 hit.
TIGRFAMsiTIGR00723. ttdB_fumA_fumB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AC35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILTTPIK AEDLQDIRVG DVIYLTGTLV TCRDVCHRRL IELKRPIPYD
60 70 80 90 100
LNGKAIFHAG PIVRKNGDKW EMVSVGPTTS MRMESFEREF IEQTGVKLVV
110 120 130 140 150
GKGGMGPLTE EGCQKFKALH VIFPAGCAVL AATQVEEIEE VHWTELGMPE
160 170 180 190 200
SLWVCRVKEF GPLIVSIDTH GNNLIAENKK LFAERRDPIV EEICEHVHYI

K
Length:201
Mass (Da):22,679
Last modified:November 8, 2005 - v1
Checksum:iE81321CD19A8BE5C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 856SMRMES → QYAYGK (PubMed:8371115).Curated
Sequence conflicti80 – 856SMRMES → QYAYGK (PubMed:3297921).Curated
Sequence conflicti165 – 1651V → A (PubMed:8371115).Curated
Sequence conflicti165 – 1651V → A (PubMed:3297921).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14781 Unassigned DNA. Translation: AAA03062.1.
M16194 Genomic DNA. Translation: AAA72574.1.
U28379 Genomic DNA. Translation: AAA89142.1.
U00096 Genomic DNA. Translation: AAC76098.1.
AP009048 Genomic DNA. Translation: BAE77113.1.
PIRiD65094. QQECRZ.
RefSeqiNP_417534.1. NC_000913.3.
WP_000722957.1. NZ_CP014272.1.

Genome annotation databases

EnsemblBacteriaiAAC76098; AAC76098; b3062.
BAE77113; BAE77113; BAE77113.
GeneIDi947568.
KEGGiecj:JW3034.
eco:b3062.
PATRICi32121538. VBIEscCol129921_3156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14781 Unassigned DNA. Translation: AAA03062.1.
M16194 Genomic DNA. Translation: AAA72574.1.
U28379 Genomic DNA. Translation: AAA89142.1.
U00096 Genomic DNA. Translation: AAC76098.1.
AP009048 Genomic DNA. Translation: BAE77113.1.
PIRiD65094. QQECRZ.
RefSeqiNP_417534.1. NC_000913.3.
WP_000722957.1. NZ_CP014272.1.

3D structure databases

ProteinModelPortaliP0AC35.
SMRiP0AC35. Positions 1-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261199. 429 interactions.
IntActiP0AC35. 2 interactions.
STRINGi511145.b3062.

Proteomic databases

PaxDbiP0AC35.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76098; AAC76098; b3062.
BAE77113; BAE77113; BAE77113.
GeneIDi947568.
KEGGiecj:JW3034.
eco:b3062.
PATRICi32121538. VBIEscCol129921_3156.

Organism-specific databases

EchoBASEiEB1157.
EcoGeneiEG11169. ttdB.

Phylogenomic databases

eggNOGiENOG4107GFK. Bacteria.
COG1838. LUCA.
HOGENOMiHOG000225718.
InParanoidiP0AC35.
KOiK03780.
OMAiIYHAGPI.
OrthoDBiEOG6TXR10.
PhylomeDBiP0AC35.

Enzyme and pathway databases

BioCyciEcoCyc:TTDB-MONOMER.
ECOL316407:JW3034-MONOMER.
MetaCyc:TTDB-MONOMER.

Miscellaneous databases

PROiP0AC35.

Family and domain databases

Gene3Di3.20.130.10. 1 hit.
InterProiIPR004647. Fe-S_hydro-lyase_TtdB-typ_cat.
[Graphical view]
PfamiPF05683. Fumerase_C. 1 hit.
[Graphical view]
SUPFAMiSSF117457. SSF117457. 1 hit.
TIGRFAMsiTIGR00723. ttdB_fumA_fumB. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the L-tartrate dehydratase genes (ttdA and ttdB) of Escherichia coli and evolutionary relationship with the class I fumarase genes."
    Reaney S.K., Begg C., Bungard S.I., Guest J.R.
    J. Gen. Microbiol. 139:1523-1530(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY, SUBUNIT.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. "Possible new genes as revealed by molecular analysis of a 5-kb Escherichia coli chromosomal region 5' to the rpsU-dnaG-rpoD macromolecular-synthesis operon."
    Nesin M., Lupski J.R., Svec P., Godson G.N.
    Gene 51:149-161(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Functional identification of ygiP as a positive regulator of the ttdA-ttdB-ygjE operon."
    Oshima T., Biville F.
    Microbiology 152:2129-2135(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiTTDB_ECOLI
AccessioniPrimary (citable) accession number: P0AC35
Secondary accession number(s): P05851, P33131, Q2M9E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 11, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.