P0AC30 (FTSX_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell division protein FtsX

Gene names

Name:	ftsX
Synonyms:	ftsS
Ordered Locus Names:	b3462, JW3427

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Not known. Is coded in an operon essential for cell division.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Inferred from mutant phenotype. Source: EcoliWiki
Cellular component	cell division site part Inferred from direct assay. Source: EcoliWiki integral to membrane Inferred from direct assay. Source: EcoliWiki plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Cell division protein FtsX		PRO_0000166792
Regions
	Topological domain	1 – 74	74	Cytoplasmic Potential
	Transmembrane	75 – 95	21	Helical; Potential
	Topological domain	96 – 223	128	Periplasmic Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Topological domain	245 – 275	31	Cytoplasmic Potential
	Transmembrane	276 – 296	21	Helical; Potential
	Topological domain	297 – 322	26	Periplasmic Potential
	Transmembrane	323 – 343	21	Helical; Potential
	Topological domain	344 – 352	9	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	P0AC30 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: C006ED56043739AE	FASTA	352	38,544
	10 20 30 40 50 60 MNKRDAINHI RQFGGRLDRF RKSVGGSGDG GRNAPKRAKS SPKPVNRKTN VFNEQVRYAF 70 80 90 100 110 120 HGALQDLKSK PFATFLTVMV IAISLTLPSV CYMVYKNVNQ AATQYYPSPQ ITVYLQKTLD 130 140 150 160 170 180 DDAAAGVVAQ LQAEQGVEKV NYLSREDALG EFRNWSGFGG ALDMLEENPL PAVAVVIPKL 190 200 210 220 230 240 DFQGTESLNT LRDRITQING IDEVRMDDSW FARLAALTGL VGRVSAMIGV LMVAAVFLVI 250 260 270 280 290 300 GNSVRLSIFA RRDSINVQKL IGATDGFILR PFLYGGALLG FSGALLSLIL SEILVLRLSS 310 320 330 340 350 AVAEVAQVFG TKFDINGLSF DECLLLLLVC SMIGWVAAWL ATVQHLRHFT PE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new cell division operon in Escherichia coli." Gill D.R., Hatfull G.F., Salmond G.P.C. Mol. Gen. Genet. 205:134-145(1986) [PubMed: 3025556] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes." Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R. Nucleic Acids Res. 22:2576-2586(1994) [PubMed: 8041620] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Global topology analysis of the Escherichia coli inner membrane proteome." Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G. Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X04398 Genomic DNA. Translation: CAA27986.1. U00039 Genomic DNA. Translation: AAB18437.1. U00096 Genomic DNA. Translation: AAC76487.1. AP009048 Genomic DNA. Translation: BAE77831.1.
PIR	CEECFX. S03132.
RefSeq	NP_417919.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P0AC30.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-35993N.
IntAct	P0AC30. 4 interactions.
Proteomic databases
PRIDE	P0AC30.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000003909; EBESCP00000003909; EBESCG00000003196. EBESCT00000017701; EBESCP00000016992; EBESCG00000016757.
GeneID	947969.
GenomeReviews	Gene locus JW3427 in contig AP009048_GR. Gene locus b3462 in contig U00096_GR.
KEGG	ecj:JW3427. eco:b3462.
PATRIC	32122368. VBIEscCol129921_3561.
Organism-specific databases
EchoBASE	EB0341.
EcoGene	EG10345. ftsX.
Phylogenomic databases
eggNOG	COG2177.
GeneTree	EBGT00050000009948.
HOGENOM	HBG353984.
OMA	IGSFFTC.
PhylomeDB	P0AC30.
ProtClustDB	PRK11026.
Enzyme and pathway databases
BioCyc	EcoCyc:FTSX-MONOMER.
Gene expression databases
Genevestigator	P0AC30.
Family and domain databases
InterPro	IPR004513. ABC_transpt_FtsX. IPR003838. Permease_FtsX-like. [Graphical view]
KO	K09811.
Pfam	PF02687. FtsX. 1 hit. [Graphical view]
TIGRFAMs	TIGR00439. FtsX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FTSX_ECOLI

Accession

Primary (citable) accession number: P0AC30
Secondary accession number(s): P10122, Q2M7C5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program