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Protein

Nitrite transporter NirC

Gene

nirC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane. Is up to 10-fold more active than NarK or NarU in nitrite uptake for subsequent reduction in the cytoplasm by the NirB/NirD nitrite reductase.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNitrate assimilation, Transport

Enzyme and pathway databases

BioCyciEcoCyc:NIRC-MONOMER
MetaCyc:NIRC-MONOMER

Protein family/group databases

TCDBi1.A.16.3.1 the formate-nitrite transporter (fnt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrite transporter NirC
Gene namesi
Name:nirC
Ordered Locus Names:b3367, JW3330
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10654 nirC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 59PeriplasmicSequence analysisAdd BLAST13
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 112CytoplasmicSequence analysisAdd BLAST32
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 151PeriplasmicSequence analysisAdd BLAST18
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 179CytoplasmicSequence analysis7
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 225PeriplasmicSequence analysisAdd BLAST25
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 268CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947241 – 268Nitrite transporter NirCAdd BLAST268

Proteomic databases

PaxDbiP0AC26
PRIDEiP0AC26

Interactioni

Protein-protein interaction databases

BioGridi4262477, 13 interactors
STRINGi316385.ECDH10B_3543

Structurei

3D structure databases

ProteinModelPortaliP0AC26
SMRiP0AC26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107V9H Bacteria
COG2116 LUCA
HOGENOMiHOG000271392
InParanoidiP0AC26
KOiK02598
OMAiSIRPLVM
PhylomeDBiP0AC26

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR000292 For/NO2_transpt
IPR024002 For/NO2_transpt_CS
PANTHERiPTHR30520 PTHR30520, 1 hit
PfamiView protein in Pfam
PF01226 Form_Nir_trans, 1 hit
TIGRFAMsiTIGR00790 fnt, 1 hit
PROSITEiView protein in PROSITE
PS01005 FORMATE_NITRITE_TP_1, 1 hit
PS01006 FORMATE_NITRITE_TP_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0AC26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTDTINKCA ANAARIARLS ANNPLGFWVS SAMAGAYVGL GIILIFTLGN
60 70 80 90 100
LLDPSVRPLV MGATFGIALT LVIIAGSELF TGHTMFLTFG VKAGSISHGQ
110 120 130 140 150
MWAILPQTWL GNLVGSVFVA MLYSWGGGSL LPVDTSIVHS VALAKTTAPA
160 170 180 190 200
MVLFFKGALC NWLVCLAIWM ALRTEGAAKF IAIWWCLLAF IASGYEHSIA
210 220 230 240 250
NMTLFALSWF GNHSEAYTLA GIGHNLLWVT LGNTLSGAVF MGLGYWYATP
260
KANRPVADKF NQTETAAG
Length:268
Mass (Da):28,563
Last modified:November 8, 2005 - v1
Checksum:i6E01788EA8FB8F31
GO

Sequence cautioni

The sequence AAA58164 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA32418 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14202 Genomic DNA Translation: CAA32418.1 Different initiation.
U18997 Genomic DNA Translation: AAA58164.1 Different initiation.
U00096 Genomic DNA Translation: AAC76392.2
AP009048 Genomic DNA Translation: BAE77923.1
PIRiB65131
RefSeqiWP_000493556.1, NZ_CP014272.1
YP_026212.2, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAC76392; AAC76392; b3367
BAE77923; BAE77923; BAE77923
GeneIDi2847757
KEGGiecj:JW3330
eco:b3367
PATRICifig|1411691.4.peg.3362

Similar proteinsi

Entry informationi

Entry nameiNIRC_ECOLI
AccessioniPrimary (citable) accession number: P0AC26
Secondary accession number(s): P11097, P78112, Q2M733
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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