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Protein

Nitrite transporter NirC

Gene

nirC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane. Is up to 10-fold more active than NarK or NarU in nitrite uptake for subsequent reduction in the cytoplasm by the NirB/NirD nitrite reductase.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Nitrate assimilation, Transport

Enzyme and pathway databases

BioCyciEcoCyc:NIRC-MONOMER.
ECOL316407:JW3330-MONOMER.
MetaCyc:NIRC-MONOMER.

Protein family/group databases

TCDBi1.A.16.3.1. the formate-nitrite transporter (fnt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrite transporter NirC
Gene namesi
Name:nirC
Ordered Locus Names:b3367, JW3330
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10654. nirC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 59PeriplasmicSequence analysisAdd BLAST13
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 112CytoplasmicSequence analysisAdd BLAST32
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 151PeriplasmicSequence analysisAdd BLAST18
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 179CytoplasmicSequence analysis7
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 225PeriplasmicSequence analysisAdd BLAST25
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 268CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947241 – 268Nitrite transporter NirCAdd BLAST268

Proteomic databases

PaxDbiP0AC26.
PRIDEiP0AC26.

Interactioni

Protein-protein interaction databases

BioGridi4262477. 13 interactors.
STRINGi511145.b3367.

Structurei

3D structure databases

ProteinModelPortaliP0AC26.
SMRiP0AC26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107V9H. Bacteria.
COG2116. LUCA.
HOGENOMiHOG000271392.
InParanoidiP0AC26.
KOiK02598.
OMAiKYAHVMT.
PhylomeDBiP0AC26.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000292. For/NO2_transpt.
IPR024002. For/NO2_transpt_CS.
[Graphical view]
PfamiPF01226. Form_Nir_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00790. fnt. 1 hit.
PROSITEiPS01005. FORMATE_NITRITE_TP_1. 1 hit.
PS01006. FORMATE_NITRITE_TP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AC26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTDTINKCA ANAARIARLS ANNPLGFWVS SAMAGAYVGL GIILIFTLGN
60 70 80 90 100
LLDPSVRPLV MGATFGIALT LVIIAGSELF TGHTMFLTFG VKAGSISHGQ
110 120 130 140 150
MWAILPQTWL GNLVGSVFVA MLYSWGGGSL LPVDTSIVHS VALAKTTAPA
160 170 180 190 200
MVLFFKGALC NWLVCLAIWM ALRTEGAAKF IAIWWCLLAF IASGYEHSIA
210 220 230 240 250
NMTLFALSWF GNHSEAYTLA GIGHNLLWVT LGNTLSGAVF MGLGYWYATP
260
KANRPVADKF NQTETAAG
Length:268
Mass (Da):28,563
Last modified:November 8, 2005 - v1
Checksum:i6E01788EA8FB8F31
GO

Sequence cautioni

The sequence AAA58164 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA32418 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14202 Genomic DNA. Translation: CAA32418.1. Different initiation.
U18997 Genomic DNA. Translation: AAA58164.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76392.2.
AP009048 Genomic DNA. Translation: BAE77923.1.
PIRiB65131.
RefSeqiWP_000493556.1. NZ_CP014272.1.
YP_026212.2. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC76392; AAC76392; b3367.
BAE77923; BAE77923; BAE77923.
GeneIDi2847757.
KEGGiecj:JW3330.
eco:b3367.
PATRICi32122168. VBIEscCol129921_3461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14202 Genomic DNA. Translation: CAA32418.1. Different initiation.
U18997 Genomic DNA. Translation: AAA58164.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76392.2.
AP009048 Genomic DNA. Translation: BAE77923.1.
PIRiB65131.
RefSeqiWP_000493556.1. NZ_CP014272.1.
YP_026212.2. NC_000913.3.

3D structure databases

ProteinModelPortaliP0AC26.
SMRiP0AC26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262477. 13 interactors.
STRINGi511145.b3367.

Protein family/group databases

TCDBi1.A.16.3.1. the formate-nitrite transporter (fnt) family.

Proteomic databases

PaxDbiP0AC26.
PRIDEiP0AC26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76392; AAC76392; b3367.
BAE77923; BAE77923; BAE77923.
GeneIDi2847757.
KEGGiecj:JW3330.
eco:b3367.
PATRICi32122168. VBIEscCol129921_3461.

Organism-specific databases

EchoBASEiEB0648.
EcoGeneiEG10654. nirC.

Phylogenomic databases

eggNOGiENOG4107V9H. Bacteria.
COG2116. LUCA.
HOGENOMiHOG000271392.
InParanoidiP0AC26.
KOiK02598.
OMAiKYAHVMT.
PhylomeDBiP0AC26.

Enzyme and pathway databases

BioCyciEcoCyc:NIRC-MONOMER.
ECOL316407:JW3330-MONOMER.
MetaCyc:NIRC-MONOMER.

Miscellaneous databases

PROiP0AC26.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000292. For/NO2_transpt.
IPR024002. For/NO2_transpt_CS.
[Graphical view]
PfamiPF01226. Form_Nir_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00790. fnt. 1 hit.
PROSITEiPS01005. FORMATE_NITRITE_TP_1. 1 hit.
PS01006. FORMATE_NITRITE_TP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIRC_ECOLI
AccessioniPrimary (citable) accession number: P0AC26
Secondary accession number(s): P11097, P78112, Q2M733
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.