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Protein

Probable formate transporter 1

Gene

focA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the bidirectional transport of formate.

GO - Molecular functioni

  • formate transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • formate transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:FOCA-MONOMER.
ECOL316407:JW0887-MONOMER.
MetaCyc:FOCA-MONOMER.

Protein family/group databases

TCDBi1.A.16.1.1. the formate-nitrite transporter (fnt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable formate transporter 1
Alternative name(s):
Formate channel 1
Gene namesi
Name:focA
Synonyms:ycaE
Ordered Locus Names:b0904, JW0887
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11258. focA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 53HelicalSequence analysisAdd BLAST17
Topological domaini54 – 68ExtracellularSequence analysisAdd BLAST15
Transmembranei69 – 85HelicalSequence analysisAdd BLAST17
Topological domaini86 – 116CytoplasmicSequence analysisAdd BLAST31
Transmembranei117 – 133HelicalSequence analysisAdd BLAST17
Topological domaini134 – 164ExtracellularSequence analysisAdd BLAST31
Transmembranei165 – 183HelicalSequence analysisAdd BLAST19
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 207HelicalSequence analysisAdd BLAST16
Topological domaini208 – 259ExtracellularSequence analysisAdd BLAST52
Transmembranei260 – 279HelicalSequence analysisAdd BLAST20
Topological domaini280 – 285CytoplasmicSequence analysis6

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947171 – 285Probable formate transporter 1Add BLAST285

Proteomic databases

PaxDbiP0AC23.
PRIDEiP0AC23.

Interactioni

Protein-protein interaction databases

BioGridi4260836. 3 interactors.
DIPiDIP-9670N.
IntActiP0AC23. 1 interactor.
MINTiMINT-1274847.
STRINGi511145.b0904.

Structurei

3D structure databases

ProteinModelPortaliP0AC23.
SMRiP0AC23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105TMB. Bacteria.
COG2116. LUCA.
HOGENOMiHOG000271393.
InParanoidiP0AC23.
KOiK06212.
OMAiKGIGCNW.
PhylomeDBiP0AC23.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000292. For/NO2_transpt.
IPR024002. For/NO2_transpt_CS.
IPR023999. Formate_transptr_FocA_put.
[Graphical view]
PfamiPF01226. Form_Nir_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00790. fnt. 1 hit.
TIGR04060. formate_focA. 1 hit.
PROSITEiPS01005. FORMATE_NITRITE_TP_1. 1 hit.
PS01006. FORMATE_NITRITE_TP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AC23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKADNPFDLL LPAAMAKVAE EAGVYKATKH PLKTFYLAIT AGVFISIAFV
60 70 80 90 100
FYITATTGTG TMPFGMAKLV GGICFSLGLI LCVVCGADLF TSTVLIVVAK
110 120 130 140 150
ASGRITWGQL AKNWLNVYFG NLVGALLFVL LMWLSGEYMT ANGQWGLNVL
160 170 180 190 200
QTADHKVHHT FIEAVCLGIL ANLMVCLAVW MSYSGRSLMD KAFIMVLPVA
210 220 230 240 250
MFVASGFEHS IANMFMIPMG IVIRDFASPE FWTAVGSAPE NFSHLTVMNF
260 270 280
ITDNLIPVTI GNIIGGGLLV GLTYWVIYLR ENDHH
Length:285
Mass (Da):30,991
Last modified:November 8, 2005 - v1
Checksum:iE0B06FFFC362DE16
GO

Sequence cautioni

The sequence AAA20390 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009048 Genomic DNA. Translation: BAA35639.1.
M26413 Genomic DNA. Translation: AAA20390.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73990.1.
PIRiA32305.
RefSeqiNP_415424.1. NC_000913.3.
WP_000642546.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73990; AAC73990; b0904.
BAA35639; BAA35639; BAA35639.
GeneIDi945513.
KEGGiecj:JW0887.
eco:b0904.
PATRICi32117021. VBIEscCol129921_0935.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009048 Genomic DNA. Translation: BAA35639.1.
M26413 Genomic DNA. Translation: AAA20390.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73990.1.
PIRiA32305.
RefSeqiNP_415424.1. NC_000913.3.
WP_000642546.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AC23.
SMRiP0AC23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260836. 3 interactors.
DIPiDIP-9670N.
IntActiP0AC23. 1 interactor.
MINTiMINT-1274847.
STRINGi511145.b0904.

Protein family/group databases

TCDBi1.A.16.1.1. the formate-nitrite transporter (fnt) family.

Proteomic databases

PaxDbiP0AC23.
PRIDEiP0AC23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73990; AAC73990; b0904.
BAA35639; BAA35639; BAA35639.
GeneIDi945513.
KEGGiecj:JW0887.
eco:b0904.
PATRICi32117021. VBIEscCol129921_0935.

Organism-specific databases

EchoBASEiEB1238.
EcoGeneiEG11258. focA.

Phylogenomic databases

eggNOGiENOG4105TMB. Bacteria.
COG2116. LUCA.
HOGENOMiHOG000271393.
InParanoidiP0AC23.
KOiK06212.
OMAiKGIGCNW.
PhylomeDBiP0AC23.

Enzyme and pathway databases

BioCyciEcoCyc:FOCA-MONOMER.
ECOL316407:JW0887-MONOMER.
MetaCyc:FOCA-MONOMER.

Miscellaneous databases

PROiP0AC23.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000292. For/NO2_transpt.
IPR024002. For/NO2_transpt_CS.
IPR023999. Formate_transptr_FocA_put.
[Graphical view]
PfamiPF01226. Form_Nir_trans. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00790. fnt. 1 hit.
TIGR04060. formate_focA. 1 hit.
PROSITEiPS01005. FORMATE_NITRITE_TP_1. 1 hit.
PS01006. FORMATE_NITRITE_TP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOCA_ECOLI
AccessioniPrimary (citable) accession number: P0AC23
Secondary accession number(s): P21501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.