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Protein

Probable formate transporter 1

Gene

focA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the bidirectional transport of formate.

GO - Molecular functioni

  • formate transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • formate transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:FOCA-MONOMER
MetaCyc:FOCA-MONOMER

Protein family/group databases

TCDBi1.A.16.1.1 the formate-nitrite transporter (fnt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Probable formate transporter 1
Alternative name(s):
Formate channel 1
Gene namesi
Name:focA
Synonyms:ycaE
Ordered Locus Names:b0904, JW0887
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11258 focA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 53HelicalSequence analysisAdd BLAST17
Topological domaini54 – 68ExtracellularSequence analysisAdd BLAST15
Transmembranei69 – 85HelicalSequence analysisAdd BLAST17
Topological domaini86 – 116CytoplasmicSequence analysisAdd BLAST31
Transmembranei117 – 133HelicalSequence analysisAdd BLAST17
Topological domaini134 – 164ExtracellularSequence analysisAdd BLAST31
Transmembranei165 – 183HelicalSequence analysisAdd BLAST19
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 207HelicalSequence analysisAdd BLAST16
Topological domaini208 – 259ExtracellularSequence analysisAdd BLAST52
Transmembranei260 – 279HelicalSequence analysisAdd BLAST20
Topological domaini280 – 285CytoplasmicSequence analysis6

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947171 – 285Probable formate transporter 1Add BLAST285

Proteomic databases

PaxDbiP0AC23
PRIDEiP0AC23

Interactioni

Protein-protein interaction databases

BioGridi4260836, 8 interactors
DIPiDIP-9670N
IntActiP0AC23, 1 interactor
STRINGi316385.ECDH10B_0974

Structurei

3D structure databases

ProteinModelPortaliP0AC23
SMRiP0AC23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105TMB Bacteria
COG2116 LUCA
HOGENOMiHOG000271393
InParanoidiP0AC23
KOiK06212
OMAiKGIGCNW
PhylomeDBiP0AC23

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR000292 For/NO2_transpt
IPR024002 For/NO2_transpt_CS
IPR023999 Formate_transptr_FocA_put
PANTHERiPTHR30520 PTHR30520, 1 hit
PfamiView protein in Pfam
PF01226 Form_Nir_trans, 1 hit
TIGRFAMsiTIGR00790 fnt, 1 hit
TIGR04060 formate_focA, 1 hit
PROSITEiView protein in PROSITE
PS01005 FORMATE_NITRITE_TP_1, 1 hit
PS01006 FORMATE_NITRITE_TP_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0AC23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKADNPFDLL LPAAMAKVAE EAGVYKATKH PLKTFYLAIT AGVFISIAFV
60 70 80 90 100
FYITATTGTG TMPFGMAKLV GGICFSLGLI LCVVCGADLF TSTVLIVVAK
110 120 130 140 150
ASGRITWGQL AKNWLNVYFG NLVGALLFVL LMWLSGEYMT ANGQWGLNVL
160 170 180 190 200
QTADHKVHHT FIEAVCLGIL ANLMVCLAVW MSYSGRSLMD KAFIMVLPVA
210 220 230 240 250
MFVASGFEHS IANMFMIPMG IVIRDFASPE FWTAVGSAPE NFSHLTVMNF
260 270 280
ITDNLIPVTI GNIIGGGLLV GLTYWVIYLR ENDHH
Length:285
Mass (Da):30,991
Last modified:November 8, 2005 - v1
Checksum:iE0B06FFFC362DE16
GO

Sequence cautioni

The sequence AAA20390 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009048 Genomic DNA Translation: BAA35639.1
M26413 Genomic DNA Translation: AAA20390.1 Different initiation.
U00096 Genomic DNA Translation: AAC73990.1
PIRiA32305
RefSeqiNP_415424.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAC73990; AAC73990; b0904
BAA35639; BAA35639; BAA35639
GeneIDi945513
KEGGiecj:JW0887
eco:b0904
PATRICifig|1411691.4.peg.1372

Similar proteinsi

Entry informationi

Entry nameiFOCA_ECOLI
AccessioniPrimary (citable) accession number: P0AC23
Secondary accession number(s): P21501
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health