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Protein

Dihydropteroate synthase

Gene

folP

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.By similarity

Catalytic activityi

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (folP), Dihydropteroate synthase (folP), Dihydropteroate synthase type-2 (sulII), Dihydropteroate synthase (sulI), Dihydropteroate synthase (RK59_010425), Dihydropteroate synthase (CEG98_00730)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22MagnesiumBy similarity1
Binding sitei626-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei966-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1156-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1856-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2216-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFolate biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
Ordered Locus Names:SF3217, S3435
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682091 – 282Dihydropteroate synthaseAdd BLAST282

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0AC15
SMRiP0AC15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 267Pterin-bindingPROSITE-ProRule annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni255 – 2576-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

Belongs to the DHPS family.Curated

Phylogenomic databases

eggNOGiENOG4105EEI Bacteria
COG0294 LUCA
HOGENOMiHOG000217510
KOiK00796

Family and domain databases

CDDicd00739 DHPS, 1 hit
Gene3Di3.20.20.20, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P0AC15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFAQGTSL DLSHPHVMGI LNVTPDSFSD GGTHNSLIDA VKHANLMINA
60 70 80 90 100
GATIIDVGGE STRPGAAEVS VEEELQRVIP VVEAIAQRFE VWISVDTSKP
110 120 130 140 150
EVIRESAKVG AHIINDIRSL SEPGALEAAA ETGLPVCLMH MQGNPKTMQE
160 170 180 190 200
APKYDDVFAE VNRYFIEQIA RCEQAGIAKE KLLLDPGFGF GKNLSHNYSL
210 220 230 240 250
LARLAEFHHF NLPLLVGMSR KSMIGQLLNV GPSERLSGSL ACAVIAAMQG
260 270 280
AHIIRVHDVK ETVEAMRVVE ATLSAKENKR YE
Length:282
Mass (Da):30,615
Last modified:November 8, 2005 - v1
Checksum:i6230C8883796F59E
GO

Sequence cautioni

The sequence AAN44683 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP18497 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN44683.2 Different initiation.
AE014073 Genomic DNA Translation: AAP18497.1 Different initiation.
RefSeqiNP_708976.4, NC_004337.2
WP_000764731.1, NZ_NIYV01000068.1

Genome annotation databases

EnsemblBacteriaiAAN44683; AAN44683; SF3217
AAP18497; AAP18497; S3435
GeneIDi1027106
KEGGisfl:SF3217
sfx:S3435
PATRICifig|198214.7.peg.3817

Similar proteinsi

Entry informationi

Entry nameiDHPS_SHIFL
AccessioniPrimary (citable) accession number: P0AC15
Secondary accession number(s): P26282, P78110
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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