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P0AC11

- DHP2_ECOLX

UniProt

P0AC11 - DHP2_ECOLX

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Protein

Dihydropteroate synthase type-2

Gene

sulII

Organism
Escherichia coli
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide. The type II enzyme is stable whereas type I DHPS loses its activity rapidly.

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121MagnesiumBy similarity
Binding sitei20 – 201SubstrateBy similarity
Binding sitei85 – 851SubstrateBy similarity
Binding sitei104 – 1041SubstrateBy similarity
Binding sitei174 – 1741SubstrateBy similarity
Binding sitei213 – 2131SubstrateBy similarity
Binding sitei247 – 2471SubstrateBy similarity
Binding sitei249 – 2491SubstrateBy similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase type-2 (EC:2.5.1.15)
Alternative name(s):
Dihydropteroate pyrophosphorylase type II
Dihydropteroate synthase type II
Short name:
DHPS
Gene namesi
Name:sulII
Encoded oniPlasmid pGS051 Publication
Plasmid pGS03B1 Publication
Plasmid IncQ RSF10101 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Dihydropteroate synthase type-2PRO_0000168203Add
BLAST

Proteomic databases

PRIDEiP0AC11.

Interactioni

Subunit structurei

Homodimer.Curated

Structurei

3D structure databases

ProteinModelPortaliP0AC11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 259259Pterin-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 532Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AC11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKSLIIFGI VNITSDSFSD GGRYLAPDAA IAQARKLMAE GADVIDLGPA
60 70 80 90 100
SSNPDAAPVS SDTEIARIAP VLDALKADGI PVSLDSYQPA TQAYALSRGV
110 120 130 140 150
AYLNDIRGFP DAAFYPQLAK SSAKLVVMHS VQDGQADRRE APAGDIMDHI
160 170 180 190 200
AAFFDARIAA LTGAGIKRNR LVLDPGMGFF LGAAPETSLS VLARFDELRL
210 220 230 240 250
RFDLPVLLSV SRKSFLRALT GRGPGDVGAA TLAAELAAAA GGADFIRTHE
260 270
PRPLRDGLAV LAALKETARI R
Length:271
Mass (Da):28,470
Last modified:November 8, 2005 - v1
Checksum:i4B00E71A3F7970FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36657 Genomic DNA. Translation: AAA24936.1.
PIRiA34950.
RefSeqiNP_957531.1. NC_005324.1.
YP_002455756.1. NC_011795.1.
YP_002891091.1. NC_012690.1.
YP_002894395.1. NC_012692.1.
YP_002995721.1. NC_012886.1.
YP_006940094.1. NC_018995.1.
YP_006952281.1. NC_019060.1.
YP_006952747.1. NC_019065.1.
YP_006952891.1. NC_019066.1.
YP_006953258.1. NC_019070.1.
YP_006953602.1. NC_019080.1.
YP_007349479.1. NC_020086.1.
YP_008574999.1. NC_022377.1.
YP_794145.1. NC_008490.1.
YP_891140.1. NC_008597.1.

Genome annotation databases

GeneIDi13877054.
13905222.
13905650.
13905795.
13906179.
13906535.
15152799.
17035774.
2716515.
4397525.
4525479.
7205328.
7872496.
7872620.
8094934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36657 Genomic DNA. Translation: AAA24936.1 .
PIRi A34950.
RefSeqi NP_957531.1. NC_005324.1.
YP_002455756.1. NC_011795.1.
YP_002891091.1. NC_012690.1.
YP_002894395.1. NC_012692.1.
YP_002995721.1. NC_012886.1.
YP_006940094.1. NC_018995.1.
YP_006952281.1. NC_019060.1.
YP_006952747.1. NC_019065.1.
YP_006952891.1. NC_019066.1.
YP_006953258.1. NC_019070.1.
YP_006953602.1. NC_019080.1.
YP_007349479.1. NC_020086.1.
YP_008574999.1. NC_022377.1.
YP_794145.1. NC_008490.1.
YP_891140.1. NC_008597.1.

3D structure databases

ProteinModelPortali P0AC11.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P0AC11.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13877054.
13905222.
13905650.
13905795.
13906179.
13906535.
15152799.
17035774.
2716515.
4397525.
4525479.
7205328.
7872496.
7872620.
8094934.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "RSF1010 and a conjugative plasmid contain sulII, one of two known genes for plasmid-borne sulfonamide resistance dihydropteroate synthase."
    Raedstroem P., Swedberg G.
    Antimicrob. Agents Chemother. 32:1684-1692(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Plasmid: IncQ RSF1010 pGS03B pGS05

Entry informationi

Entry nameiDHP2_ECOLX
AccessioniPrimary (citable) accession number: P0AC11
Secondary accession number(s): P19539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The sulII gene is located on various IncQ (Broad-host-range) plasmids and other small non-conjugative resistance plasmids.

Keywords - Technical termi

Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3