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Protein

Flagellar transcriptional regulator FlhC

Gene

flhC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.3 Publications

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi137Zinc1
Metal bindingi140Zinc1
Metal bindingi157Zinc1
Metal bindingi160Zinc1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processBacterial flagellum biogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2488

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar transcriptional regulator FlhC
Gene namesi
Name:flhC
Synonyms:flaI
Ordered Locus Names:b1891, JW1880
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10319 flhC

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643371 – 192Flagellar transcriptional regulator FlhCAdd BLAST192

Proteomic databases

PaxDbiP0ABY7
PRIDEiP0ABY7

Expressioni

Inductioni

Expression is regulated by a large number of systems, including induction by quorum sensing via the two-component regulatory system QseB/QseC, induction by cAMP-CRP, repression by high osmolarity via OmpR and repression by H-NS.3 Publications

Interactioni

Subunit structurei

Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.1 Publication

Protein-protein interaction databases

BioGridi4262244, 9 interactors
DIPiDIP-9645N
STRINGi316407.1736550

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 21Combined sources16
Helixi27 – 32Combined sources6
Beta strandi33 – 35Combined sources3
Helixi37 – 47Combined sources11
Beta strandi48 – 50Combined sources3
Helixi62 – 65Combined sources4
Helixi68 – 85Combined sources18
Turni86 – 88Combined sources3
Helixi92 – 105Combined sources14
Helixi117 – 128Combined sources12
Beta strandi131 – 136Combined sources6
Turni138 – 140Combined sources3
Beta strandi143 – 149Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AVUX-ray3.00E/F1-192[»]
ProteinModelPortaliP0ABY7
SMRiP0ABY7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABY7

Family & Domainsi

Sequence similaritiesi

Belongs to the FlhC family.Curated

Phylogenomic databases

eggNOGiENOG4106CIA Bacteria
ENOG410XXBZ LUCA
HOGENOMiHOG000254687
KOiK02402
OMAiMLQLSAC

Family and domain databases

HAMAPiMF_01891 FhlC, 1 hit
InterProiView protein in InterPro
IPR007944 FlhC
PfamiView protein in Pfam
PF05280 FlhC, 1 hit
PIRSFiPIRSF003159 FlhC, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016592 FlhC, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKSIVQEA RDIQLAMELI TLGARLQMLE SETQLSRGRL IKLYKELRGS
60 70 80 90 100
PPPKGMLPFS TDWFMTWEQN VHASMFCNAW QFLLKTGLCN GVDAVIKAYR
110 120 130 140 150
LYLEQCPQAE EGPLLALTRA WTLVRFVESG LLQLSSCNCC GGNFITHAHQ
160 170 180 190
PVGSFACSLC QPPSRAVKRR KLSQNPADII PQLLDEQRVQ AV
Length:192
Mass (Da):21,566
Last modified:October 25, 2005 - v1
Checksum:i4504AF0580545C0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149H → D in AAA23788 (PubMed:2832369).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19439 Genomic DNA Translation: AAA23788.1
U00096 Genomic DNA Translation: AAC74961.1
AP009048 Genomic DNA Translation: BAA15712.1
PIRiC64952 XMECIF
RefSeqiNP_416405.1, NC_000913.3
WP_001291603.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74961; AAC74961; b1891
BAA15712; BAA15712; BAA15712
GeneIDi947280
KEGGiecj:JW1880
eco:b1891
PATRICifig|1411691.4.peg.356

Similar proteinsi

Entry informationi

Entry nameiFLHC_ECOLI
AccessioniPrimary (citable) accession number: P0ABY7
Secondary accession number(s): P11165, P76303
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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