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Protein

Flagellar transcriptional regulator FlhC

Gene

flhC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.3 Publications

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi137Zinc1
Metal bindingi140Zinc1
Metal bindingi157Zinc1
Metal bindingi160Zinc1

GO - Molecular functioni

GO - Biological processi

  • bacterial-type flagellum organization Source: UniProtKB-KW
  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • regulation of bacterial-type flagellum assembly Source: UniProtKB-HAMAP
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Bacterial flagellum biogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2488.
ECOL316407:JW1880-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar transcriptional regulator FlhC
Gene namesi
Name:flhC
Synonyms:flaI
Ordered Locus Names:b1891, JW1880
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10319. flhC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643371 – 192Flagellar transcriptional regulator FlhCAdd BLAST192

Proteomic databases

PaxDbiP0ABY7.
PRIDEiP0ABY7.

Expressioni

Inductioni

Expression is regulated by a large number of systems, including induction by quorum sensing via the two-component regulatory system QseB/QseC, induction by cAMP-CRP, repression by high osmolarity via OmpR and repression by H-NS.3 Publications

Interactioni

Subunit structurei

Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.1 Publication

Protein-protein interaction databases

BioGridi4262244. 9 interactors.
DIPiDIP-9645N.
STRINGi511145.b1891.

Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 21Combined sources16
Helixi27 – 32Combined sources6
Beta strandi33 – 35Combined sources3
Helixi37 – 47Combined sources11
Beta strandi48 – 50Combined sources3
Helixi62 – 65Combined sources4
Helixi68 – 85Combined sources18
Turni86 – 88Combined sources3
Helixi92 – 105Combined sources14
Helixi117 – 128Combined sources12
Beta strandi131 – 136Combined sources6
Turni138 – 140Combined sources3
Beta strandi143 – 149Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AVUX-ray3.00E/F1-192[»]
ProteinModelPortaliP0ABY7.
SMRiP0ABY7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABY7.

Family & Domainsi

Sequence similaritiesi

Belongs to the FlhC family.Curated

Phylogenomic databases

eggNOGiENOG4106CIA. Bacteria.
ENOG410XXBZ. LUCA.
HOGENOMiHOG000254687.
KOiK02402.
OMAiMLQLSAC.

Family and domain databases

HAMAPiMF_01891. FhlC. 1 hit.
InterProiIPR007944. FlhC.
[Graphical view]
PfamiPF05280. FlhC. 1 hit.
[Graphical view]
PIRSFiPIRSF003159. FlhC. 1 hit.
ProDomiPD016592. FlhC. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P0ABY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKSIVQEA RDIQLAMELI TLGARLQMLE SETQLSRGRL IKLYKELRGS
60 70 80 90 100
PPPKGMLPFS TDWFMTWEQN VHASMFCNAW QFLLKTGLCN GVDAVIKAYR
110 120 130 140 150
LYLEQCPQAE EGPLLALTRA WTLVRFVESG LLQLSSCNCC GGNFITHAHQ
160 170 180 190
PVGSFACSLC QPPSRAVKRR KLSQNPADII PQLLDEQRVQ AV
Length:192
Mass (Da):21,566
Last modified:October 25, 2005 - v1
Checksum:i4504AF0580545C0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149H → D in AAA23788 (PubMed:2832369).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19439 Genomic DNA. Translation: AAA23788.1.
U00096 Genomic DNA. Translation: AAC74961.1.
AP009048 Genomic DNA. Translation: BAA15712.1.
PIRiC64952. XMECIF.
RefSeqiNP_416405.1. NC_000913.3.
WP_001291603.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74961; AAC74961; b1891.
BAA15712; BAA15712; BAA15712.
GeneIDi947280.
KEGGiecj:JW1880.
eco:b1891.
PATRICi32119109. VBIEscCol129921_1972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19439 Genomic DNA. Translation: AAA23788.1.
U00096 Genomic DNA. Translation: AAC74961.1.
AP009048 Genomic DNA. Translation: BAA15712.1.
PIRiC64952. XMECIF.
RefSeqiNP_416405.1. NC_000913.3.
WP_001291603.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AVUX-ray3.00E/F1-192[»]
ProteinModelPortaliP0ABY7.
SMRiP0ABY7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262244. 9 interactors.
DIPiDIP-9645N.
STRINGi511145.b1891.

Proteomic databases

PaxDbiP0ABY7.
PRIDEiP0ABY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74961; AAC74961; b1891.
BAA15712; BAA15712; BAA15712.
GeneIDi947280.
KEGGiecj:JW1880.
eco:b1891.
PATRICi32119109. VBIEscCol129921_1972.

Organism-specific databases

EchoBASEiEB0315.
EcoGeneiEG10319. flhC.

Phylogenomic databases

eggNOGiENOG4106CIA. Bacteria.
ENOG410XXBZ. LUCA.
HOGENOMiHOG000254687.
KOiK02402.
OMAiMLQLSAC.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2488.
ECOL316407:JW1880-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ABY7.
PROiP0ABY7.

Family and domain databases

HAMAPiMF_01891. FhlC. 1 hit.
InterProiIPR007944. FlhC.
[Graphical view]
PfamiPF05280. FlhC. 1 hit.
[Graphical view]
PIRSFiPIRSF003159. FlhC. 1 hit.
ProDomiPD016592. FlhC. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiFLHC_ECOLI
AccessioniPrimary (citable) accession number: P0ABY7
Secondary accession number(s): P11165, P76303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.