P0ABY4 (FLAW_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Flavodoxin-2

Gene names

Name:	fldB
Ordered Locus Names:	b2895, JW2863

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Low-potential electron donor to a number of redox enzymes Potential.
Cofactor	FMN.
Sequence similarities	Belongs to the flavodoxin family. Contains 1 flavodoxin-like domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	FMN Flavoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytosol Inferred from direct assay PubMed 7961651. Source: EcoCyc
Molecular_function	FMN binding Inferred from direct assay PubMed 7961651. Source: EcoCyc electron carrier activity Inferred from direct assay PubMed 7961651. Source: EcoCyc oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 173	173	Flavodoxin-2		PRO_0000171626
Regions
	Domain	3 – 165	163	Flavodoxin-like
Experimental info
	Sequence conflict	115	1	F → C in CAA88140. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P0ABY4 [UniParc]. Last modified October 25, 2005. Version 1. Checksum: 89338715D106A68C	FASTA	173	19,700
	10 20 30 40 50 60 MNMGLFYGSS TCYTEMAAEK IRDIIGPELV TLHNLKDDSP KLMEQYDVLI LGIPTWDFGE 70 80 90 100 110 120 IQEDWEAVWD QLDDLNLEGK IVALYGLGDQ LGYGEWFLDA LGMLHDKLST KGVKFVGYWP 130 140 150 160 170 TEGYEFTSPK PVIADGQLFV GLALDETNQY DLSDERIQSW CEQILNEMAE HYA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Putative second gene (fldB) for flavodoxin in Escherichia coli." Hayes F. Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z48060 Genomic DNA. Translation: CAA88140.1. U28375 Genomic DNA. Translation: AAA83076.1. U00096 Genomic DNA. Translation: AAC75933.1. AP009048 Genomic DNA. Translation: BAE76960.1.
PIR	G65073.
RefSeq	NP_417371.1. NC_000913.2. YP_491096.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P0ABY4.
SMR	P0ABY4. Positions 3-169.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0ABY4. 8 interactions.
STRING	511145.b2895.
Proteomic databases
PaxDb	P0ABY4.
PRIDE	P0ABY4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75933; AAC75933; b2895. BAE76960; BAE76960; BAE76960.
GeneID	12933346. 947361.
KEGG	ecj:Y75_p2827. eco:b2895.
PATRIC	32121202. VBIEscCol129921_2989.
Organism-specific databases
EchoBASE	EB2559.
EcoGene	EG12697. fldB.
Phylogenomic databases
eggNOG	COG0716.
HOGENOM	HOG000030543.
KO	K03840.
OMA	GSTTCYT.
ProtClustDB	PRK12359.
Enzyme and pathway databases
BioCyc	EcoCyc:FLAVODOXIN2-MONOMER. ECOL316407:JW2863-MONOMER.
Gene expression databases
Genevestigator	P0ABY4.
Family and domain databases
InterPro	IPR008254. Flavodoxin/NO_synth. IPR001226. Flavodoxin_CS. IPR010086. Flavodoxin_lc. [Graphical view]
Pfam	PF00258. Flavodoxin_1. 1 hit. [Graphical view]
PIRSF	PIRSF038996. FldA. 1 hit.
TIGRFAMs	TIGR01752. flav_long. 1 hit.
PROSITE	PS00201. FLAVODOXIN. 1 hit. PS50902. FLAVODOXIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FLAW_ECOLI

Accession

Primary (citable) accession number: P0ABY4
Secondary accession number(s): P41050, Q2M9U6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	October 25, 2005
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program