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Protein

Flavodoxin-2

Gene

fldB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Low-potential electron donor to a number of redox enzymes.Curated

Cofactori

GO - Molecular functioni

  • electron carrier activity Source: InterPro
  • FMN binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciEcoCyc:FLAVODOXIN2-MONOMER.
ECOL316407:JW2863-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flavodoxin-2
Gene namesi
Name:fldB
Ordered Locus Names:b2895, JW2863
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12697. fldB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Flavodoxin-2PRO_0000171626Add
BLAST

Proteomic databases

PaxDbiP0ABY4.
PRIDEiP0ABY4.

Interactioni

Protein-protein interaction databases

BioGridi4262340. 10 interactions.
IntActiP0ABY4. 8 interactions.
STRINGi511145.b2895.

Structurei

Secondary structure

1
173
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75Combined sources
Beta strandi10 – 123Combined sources
Helixi13 – 2513Combined sources
Turni27 – 293Combined sources
Beta strandi30 – 345Combined sources
Turni35 – 373Combined sources
Helixi40 – 445Combined sources
Beta strandi46 – 5611Combined sources
Turni57 – 593Combined sources
Helixi63 – 686Combined sources
Helixi71 – 744Combined sources
Beta strandi81 – 888Combined sources
Turni90 – 934Combined sources
Turni95 – 984Combined sources
Helixi99 – 11012Combined sources
Beta strandi114 – 1163Combined sources
Beta strandi129 – 1335Combined sources
Turni134 – 1374Combined sources
Beta strandi138 – 14811Combined sources
Helixi149 – 1513Combined sources
Helixi153 – 17119Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MT9NMR-A1-173[»]
2MTBNMR-A1-173[»]
ProteinModelPortaliP0ABY4.
SMRiP0ABY4. Positions 3-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 165163Flavodoxin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the flavodoxin family.Curated
Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41071R3. Bacteria.
COG0716. LUCA.
HOGENOMiHOG000030543.
InParanoidiP0ABY4.
KOiK03840.
OMAiILGISTW.
OrthoDBiEOG6C5RTW.
PhylomeDBiP0ABY4.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR001226. Flavodoxin_CS.
IPR010086. Flavodoxin_lc.
IPR029039. Flavoprotein-like_dom.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038996. FldA. 1 hit.
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01752. flav_long. 1 hit.
PROSITEiPS00201. FLAVODOXIN. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMGLFYGSS TCYTEMAAEK IRDIIGPELV TLHNLKDDSP KLMEQYDVLI
60 70 80 90 100
LGIPTWDFGE IQEDWEAVWD QLDDLNLEGK IVALYGLGDQ LGYGEWFLDA
110 120 130 140 150
LGMLHDKLST KGVKFVGYWP TEGYEFTSPK PVIADGQLFV GLALDETNQY
160 170
DLSDERIQSW CEQILNEMAE HYA
Length:173
Mass (Da):19,700
Last modified:October 25, 2005 - v1
Checksum:i89338715D106A68C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151F → C in CAA88140 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48060 Genomic DNA. Translation: CAA88140.1.
U28375 Genomic DNA. Translation: AAA83076.1.
U00096 Genomic DNA. Translation: AAC75933.1.
AP009048 Genomic DNA. Translation: BAE76960.1.
PIRiG65073.
RefSeqiNP_417371.1. NC_000913.3.
WP_001055874.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75933; AAC75933; b2895.
BAE76960; BAE76960; BAE76960.
GeneIDi947361.
KEGGiecj:JW2863.
eco:b2895.
PATRICi32121202. VBIEscCol129921_2989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48060 Genomic DNA. Translation: CAA88140.1.
U28375 Genomic DNA. Translation: AAA83076.1.
U00096 Genomic DNA. Translation: AAC75933.1.
AP009048 Genomic DNA. Translation: BAE76960.1.
PIRiG65073.
RefSeqiNP_417371.1. NC_000913.3.
WP_001055874.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MT9NMR-A1-173[»]
2MTBNMR-A1-173[»]
ProteinModelPortaliP0ABY4.
SMRiP0ABY4. Positions 3-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262340. 10 interactions.
IntActiP0ABY4. 8 interactions.
STRINGi511145.b2895.

Proteomic databases

PaxDbiP0ABY4.
PRIDEiP0ABY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75933; AAC75933; b2895.
BAE76960; BAE76960; BAE76960.
GeneIDi947361.
KEGGiecj:JW2863.
eco:b2895.
PATRICi32121202. VBIEscCol129921_2989.

Organism-specific databases

EchoBASEiEB2559.
EcoGeneiEG12697. fldB.

Phylogenomic databases

eggNOGiENOG41071R3. Bacteria.
COG0716. LUCA.
HOGENOMiHOG000030543.
InParanoidiP0ABY4.
KOiK03840.
OMAiILGISTW.
OrthoDBiEOG6C5RTW.
PhylomeDBiP0ABY4.

Enzyme and pathway databases

BioCyciEcoCyc:FLAVODOXIN2-MONOMER.
ECOL316407:JW2863-MONOMER.

Miscellaneous databases

PROiP0ABY4.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR001226. Flavodoxin_CS.
IPR010086. Flavodoxin_lc.
IPR029039. Flavoprotein-like_dom.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038996. FldA. 1 hit.
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01752. flav_long. 1 hit.
PROSITEiPS00201. FLAVODOXIN. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Putative second gene (fldB) for flavodoxin in Escherichia coli."
    Hayes F.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiFLAW_ECOLI
AccessioniPrimary (citable) accession number: P0ABY4
Secondary accession number(s): P41050, Q2M9U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.