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Protein

Uncharacterized fimbrial-like protein SfmA

Gene

sfmA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G6290-MONOMER.
ECOL316407:JW0519-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein SfmA
Alternative name(s):
Type-1A pilin
Gene namesi
Name:sfmA
Ordered Locus Names:b0530, JW0519
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13881. sfmA.

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 180158Uncharacterized fimbrial-like protein SfmAPRO_0000009174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 81Curated

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0ABW5.

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259878. 15 interactions.
IntActiP0ABW5. 13 interactions.
STRINGi511145.b0530.

Structurei

3D structure databases

ProteinModelPortaliP0ABW5.
SMRiP0ABW5. Positions 29-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108WDE. Bacteria.
ENOG4111P69. LUCA.
HOGENOMiHOG000260127.
InParanoidiP0ABW5.
KOiK07352.
OMAiATFVMKY.
OrthoDBiEOG63VC1D.
PhylomeDBiP0ABW5.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ABW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRFISSAL AAALFAATGS YAAVVDGGTI HFEGELVNAA CSVNTDSADQ
60 70 80 90 100
VVTLGQYRTD IFNAVGNTSA LIPFTIQLND CDPVVAANAA VAFSGQADAI
110 120 130 140 150
NDNLLAIASS TNTTTATGVG IEILDNTSAI LKPDGNSFST NQNLIPGTNV
160 170 180
LHFSARYKGT GTSASAGQAN ADATFIMRYE
Length:180
Mass (Da):18,475
Last modified:October 25, 2005 - v1
Checksum:i2D5CDA1585FC6EA9
GO

Sequence cautioni

The sequence AAB40283.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40283.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73632.2.
AP009048 Genomic DNA. Translation: BAE76307.1.
PIRiA64785.
RefSeqiNP_415063.4. NC_000913.3.
WP_000776555.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73632; AAC73632; b0530.
BAE76307; BAE76307; BAE76307.
GeneIDi945522.
KEGGiecj:JW0519.
eco:b0530.
PATRICi32116220. VBIEscCol129921_0551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA. Translation: AAB40283.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73632.2.
AP009048 Genomic DNA. Translation: BAE76307.1.
PIRiA64785.
RefSeqiNP_415063.4. NC_000913.3.
WP_000776555.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABW5.
SMRiP0ABW5. Positions 29-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259878. 15 interactions.
IntActiP0ABW5. 13 interactions.
STRINGi511145.b0530.

Proteomic databases

PaxDbiP0ABW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73632; AAC73632; b0530.
BAE76307; BAE76307; BAE76307.
GeneIDi945522.
KEGGiecj:JW0519.
eco:b0530.
PATRICi32116220. VBIEscCol129921_0551.

Organism-specific databases

EchoBASEiEB3640.
EcoGeneiEG13881. sfmA.

Phylogenomic databases

eggNOGiENOG4108WDE. Bacteria.
ENOG4111P69. LUCA.
HOGENOMiHOG000260127.
InParanoidiP0ABW5.
KOiK07352.
OMAiATFVMKY.
OrthoDBiEOG63VC1D.
PhylomeDBiP0ABW5.

Enzyme and pathway databases

BioCyciEcoCyc:G6290-MONOMER.
ECOL316407:JW0519-MONOMER.

Miscellaneous databases

PROiP0ABW5.

Family and domain databases

Gene3Di2.60.40.1090. 1 hit.
InterProiIPR008966. Adhesion_dom.
IPR000259. Adhesion_dom_fimbrial.
[Graphical view]
PfamiPF00419. Fimbrial. 1 hit.
[Graphical view]
SUPFAMiSSF49401. SSF49401. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-usher fimbriae with distinct surface specificities."
    Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.
    Environ. Microbiol. 12:1957-1977(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiSFMA_ECOLI
AccessioniPrimary (citable) accession number: P0ABW5
Secondary accession number(s): P77660, Q2MBP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: January 20, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.