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Protein

Uncharacterized fimbrial-like protein SfmA

Gene

sfmA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.1 Publication

Miscellaneous

The operon is cryptic under classical laboratory conditions, but is functional when constitutively expressed.1 Publication

GO - Biological processi

  • cell adhesion Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G6290-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial-like protein SfmA
Alternative name(s):
Type-1A pilin
Gene namesi
Name:sfmA
Ordered Locus Names:b0530, JW0519
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13881 sfmA

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Disruption phenotypei

Deletion of the operon under classical laboratory conditions does not result in any major effect on E.coli capacity to form biofilms compared with the wild-type strain.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000917423 – 180Uncharacterized fimbrial-like protein SfmAAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 81Curated

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP0ABW5
PRIDEiP0ABW5

Expressioni

Inductioni

Expression is negatively regulated by H-NS and subjected to cAMP receptor protein (CRP)-mediated catabolite repression.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259878, 15 interactors
IntActiP0ABW5, 13 interactors
STRINGi316385.ECDH10B_0486

Structurei

3D structure databases

ProteinModelPortaliP0ABW5
SMRiP0ABW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fimbrial protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108WDE Bacteria
ENOG4111P69 LUCA
HOGENOMiHOG000260127
InParanoidiP0ABW5
KOiK07352
OMAiATFVMKY
PhylomeDBiP0ABW5

Family and domain databases

Gene3Di2.60.40.1090, 1 hit
InterProiView protein in InterPro
IPR000259 Adhesion_dom_fimbrial
IPR036937 Adhesion_dom_fimbrial_sf
IPR008966 Adhesion_dom_sf
PfamiView protein in Pfam
PF00419 Fimbrial, 1 hit
SUPFAMiSSF49401 SSF49401, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0ABW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRFISSAL AAALFAATGS YAAVVDGGTI HFEGELVNAA CSVNTDSADQ
60 70 80 90 100
VVTLGQYRTD IFNAVGNTSA LIPFTIQLND CDPVVAANAA VAFSGQADAI
110 120 130 140 150
NDNLLAIASS TNTTTATGVG IEILDNTSAI LKPDGNSFST NQNLIPGTNV
160 170 180
LHFSARYKGT GTSASAGQAN ADATFIMRYE
Length:180
Mass (Da):18,475
Last modified:October 25, 2005 - v1
Checksum:i2D5CDA1585FC6EA9
GO

Sequence cautioni

The sequence AAB40283 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82664 Genomic DNA Translation: AAB40283.1 Different initiation.
U00096 Genomic DNA Translation: AAC73632.2
AP009048 Genomic DNA Translation: BAE76307.1
PIRiA64785
RefSeqiNP_415063.4, NC_000913.3
WP_000776555.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73632; AAC73632; b0530
BAE76307; BAE76307; BAE76307
GeneIDi945522
KEGGiecj:JW0519
eco:b0530
PATRICifig|1411691.4.peg.1748

Similar proteinsi

Entry informationi

Entry nameiSFMA_ECOLI
AccessioniPrimary (citable) accession number: P0ABW5
Secondary accession number(s): P77660, Q2MBP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health