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Protein

3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit

Gene

hcaC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol), respectively. This protein seems to be a 2Fe-2S ferredoxin.

Pathwayi: 3-phenylpropanoate degradation

This protein is involved in the pathway 3-phenylpropanoate degradation, which is part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the pathway 3-phenylpropanoate degradation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi42Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi44Iron-sulfur (2Fe-2S); via pros nitrogenSequence analysis1
Metal bindingi62Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi65Iron-sulfur (2Fe-2S); via pros nitrogenSequence analysis1

GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: EcoCyc
  • iron-sulfur cluster binding Source: EcoliWiki
  • metal ion binding Source: UniProtKB-KW
  • oxidoreductase activity Source: InterPro

GO - Biological processi

  • 3-phenylpropionate catabolic process Source: EcoCyc

Keywordsi

Biological processAromatic hydrocarbons catabolism, Electron transport, Transport
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:HCAC-MONOMER
MetaCyc:HCAC-MONOMER
BRENDAi3.7.1.14 2026
UniPathwayiUPA00714

Names & Taxonomyi

Protein namesi
Recommended name:
3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit
Gene namesi
Name:hcaC
Synonyms:hcaA3, phdB, yfhW
Ordered Locus Names:b2540, JW2524
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13458 hcaC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002016881 – 1063-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunitAdd BLAST106

Proteomic databases

PaxDbiP0ABW0
PRIDEiP0ABW0

Interactioni

Subunit structurei

This dioxygenase system consists of four proteins: the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD).

Protein-protein interaction databases

BioGridi4261575, 12 interactors
IntActiP0ABW0, 4 interactors
STRINGi316385.ECDH10B_2707

Structurei

3D structure databases

ProteinModelPortaliP0ABW0
SMRiP0ABW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 99RieskeAdd BLAST96

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105VQD Bacteria
COG2146 LUCA
HOGENOMiHOG000128541
InParanoidiP0ABW0
KOiK05710
OMAiCWLHGSR
PhylomeDBiP0ABW0

Family and domain databases

Gene3Di2.102.10.10, 1 hit
HAMAPiMF_01650 HcaC, 1 hit
InterProiView protein in InterPro
IPR023739 HcaC
IPR017941 Rieske_2Fe-2S
IPR036922 Rieske_2Fe-2S_sf
PfamiView protein in Pfam
PF00355 Rieske, 1 hit
SUPFAMiSSF50022 SSF50022, 1 hit
PROSITEiView protein in PROSITE
PS51296 RIESKE, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRIYACPVA DVPEGEALRI DTSPVIALFN VGGEFYAIND RCSHGNASMS
60 70 80 90 100
EGYLEDDATV ECPLHAASFC LKTGKALCLP ATDPLTTYPV HVEGGDIFID

LPEAQP
Length:106
Mass (Da):11,329
Last modified:October 25, 2005 - v1
Checksum:iB83149F4126BB72D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11070 Genomic DNA Translation: CAA71950.1
U00096 Genomic DNA Translation: AAC75593.1
AP009048 Genomic DNA Translation: BAA16443.1
PIRiC65031
RefSeqiNP_417035.1, NC_000913.3
WP_001080102.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75593; AAC75593; b2540
BAA16443; BAA16443; BAA16443
GeneIDi947015
KEGGiecj:JW2524
eco:b2540
PATRICifig|1411691.4.peg.4194

Similar proteinsi

Entry informationi

Entry nameiHCAC_ECOLI
AccessioniPrimary (citable) accession number: P0ABW0
Secondary accession number(s): O08099, P77266
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health