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Protein

Tol-Pal system protein TolR

Gene

tolR

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Protein family/group databases

TCDBi1.A.30.2.2 the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Tol-Pal system protein TolRUniRule annotation
Gene namesi
Name:tolRUniRule annotation
Ordered Locus Names:Z0906, ECs0773
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicCuratedAdd BLAST17
Transmembranei18 – 38HelicalUniRule annotationAdd BLAST21
Topological domaini39 – 142PeriplasmicCuratedAdd BLAST104

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001291411 – 142Tol-Pal system protein TolRAdd BLAST142

Proteomic databases

PRIDEiP0ABV8

Interactioni

Subunit structurei

The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z0906

Structurei

3D structure databases

ProteinModelPortaliP0ABV8
SMRiP0ABV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ExbD/TolR family.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105M8F Bacteria
COG0848 LUCA
HOGENOMiHOG000134906
KOiK03560
OMAiMMTHGVK

Family and domain databases

HAMAPiMF_02203 TolR, 1 hit
InterProiView protein in InterPro
IPR014168 Biopolymer_transpt_TolR
IPR003400 ExbD
PANTHERiPTHR30558 PTHR30558, 1 hit
PfamiView protein in Pfam
PF02472 ExbD, 1 hit
TIGRFAMsiTIGR02801 tolR, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARARGRGRR DLKSEINIVP LLDVLLVLLL IFMATAPIIT QSVEVDLPDA
60 70 80 90 100
TESQAVSSND NPPVIVEVSG IGQYTVVVEK DRLERLPPEQ VVAEVSSRFK
110 120 130 140
ANPKTVFLIG GAKDVPYDEI IKALNLLHSA GVKSVGLMTQ PI
Length:142
Mass (Da):15,383
Last modified:October 25, 2005 - v1
Checksum:i936FE0033172600B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG55074.1
BA000007 Genomic DNA Translation: BAB34196.1
PIRiE90725
F85576
RefSeqiNP_308800.1, NC_002695.1
WP_000090097.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG55074; AAG55074; Z0906
BAB34196; BAB34196; BAB34196
GeneIDi917504
KEGGiece:Z0906
ecs:ECs0773
PATRICifig|386585.9.peg.892

Similar proteinsi

Entry informationi

Entry nameiTOLR_ECO57
AccessioniPrimary (citable) accession number: P0ABV8
Secondary accession number(s): P05829
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health