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Protein

Protein TolR

Gene

tolR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the TonB-independent uptake of group A colicins (colicins A, E1, E2, E3, and K).

GO - Molecular functioni

GO - Biological processi

  • bacteriocin transport Source: EcoliWiki
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Bacteriocin transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11011-MONOMER.
ECOL316407:JW0728-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TolR
Gene namesi
Name:tolR
Ordered Locus Names:b0738, JW0728
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11011. tolR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Cytoplasmic1 PublicationAdd
BLAST
Transmembranei21 – 4020Helical; Signal-anchor for type II membrane proteinCuratedAdd
BLAST
Topological domaini41 – 142102Periplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • integral component of membrane Source: EcoliWiki
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoliWiki
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Protein TolRPRO_0000129140Add
BLAST

Proteomic databases

PaxDbiP0ABV6.

Interactioni

Protein-protein interaction databases

BioGridi4261829. 196 interactions.
DIPiDIP-48143N.
IntActiP0ABV6. 2 interactions.
STRINGi511145.b0738.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi52 – 576Combined sources
Beta strandi64 – 685Combined sources
Beta strandi74 – 785Combined sources
Beta strandi81 – 866Combined sources
Helixi88 – 10114Combined sources
Beta strandi107 – 1115Combined sources
Helixi117 – 12913Combined sources
Beta strandi136 – 1394Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5BY4X-ray1.70A36-142[»]
ProteinModelPortaliP0ABV6.
SMRiP0ABV6. Positions 37-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ExbD/TolR family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0848. LUCA.
HOGENOMiHOG000134906.
InParanoidiP0ABV6.
KOiK03560.
OMAiDNNTMFL.
OrthoDBiEOG6D2KWK.
PhylomeDBiP0ABV6.

Family and domain databases

InterProiIPR014168. Biopolymer_transpt_TolR.
IPR003400. ExbD.
[Graphical view]
PfamiPF02472. ExbD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02801. tolR. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARARGRGRR DLKSEINIVP LLDVLLVLLL IFMATAPIIT QSVEVDLPDA
60 70 80 90 100
TESQAVSSND NPPVIVEVSG IGQYTVVVEK DRLERLPPEQ VVAEVSSRFK
110 120 130 140
ANPKTVFLIG GAKDVPYDEI IKALNLLHSA GVKSVGLMTQ PI
Length:142
Mass (Da):15,383
Last modified:October 25, 2005 - v1
Checksum:i936FE0033172600B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16489 Genomic DNA. Translation: AAA83921.1.
U00096 Genomic DNA. Translation: AAC73832.1.
AP009048 Genomic DNA. Translation: BAA35404.1.
PIRiC25980. BVECTR.
RefSeqiNP_415266.1. NC_000913.3.
WP_000090097.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73832; AAC73832; b0738.
BAA35404; BAA35404; BAA35404.
GeneIDi945328.
KEGGiecj:JW0728.
eco:b0738.
PATRICi32116675. VBIEscCol129921_0770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16489 Genomic DNA. Translation: AAA83921.1.
U00096 Genomic DNA. Translation: AAC73832.1.
AP009048 Genomic DNA. Translation: BAA35404.1.
PIRiC25980. BVECTR.
RefSeqiNP_415266.1. NC_000913.3.
WP_000090097.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5BY4X-ray1.70A36-142[»]
ProteinModelPortaliP0ABV6.
SMRiP0ABV6. Positions 37-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261829. 196 interactions.
DIPiDIP-48143N.
IntActiP0ABV6. 2 interactions.
STRINGi511145.b0738.

Proteomic databases

PaxDbiP0ABV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73832; AAC73832; b0738.
BAA35404; BAA35404; BAA35404.
GeneIDi945328.
KEGGiecj:JW0728.
eco:b0738.
PATRICi32116675. VBIEscCol129921_0770.

Organism-specific databases

EchoBASEiEB1004.
EcoGeneiEG11011. tolR.

Phylogenomic databases

eggNOGiCOG0848. LUCA.
HOGENOMiHOG000134906.
InParanoidiP0ABV6.
KOiK03560.
OMAiDNNTMFL.
OrthoDBiEOG6D2KWK.
PhylomeDBiP0ABV6.

Enzyme and pathway databases

BioCyciEcoCyc:EG11011-MONOMER.
ECOL316407:JW0728-MONOMER.

Miscellaneous databases

PROiP0ABV6.

Family and domain databases

InterProiIPR014168. Biopolymer_transpt_TolR.
IPR003400. ExbD.
[Graphical view]
PfamiPF02472. ExbD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02801. tolR. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a gene cluster involved in entry of E colicins and single-stranded DNA of infecting filamentous bacteriophages into Escherichia coli."
    Sun T.-P., Webster R.E.
    J. Bacteriol. 169:2667-2674(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Membrane topologies of the TolQ and TolR proteins of Escherichia coli: inactivation of TolQ by a missense mutation in the proposed first transmembrane segment."
    Kampfenkel K., Braun V.
    J. Bacteriol. 175:4485-4491(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY.

Entry informationi

Entry nameiTOLR_ECOLI
AccessioniPrimary (citable) accession number: P0ABV6
Secondary accession number(s): P05829
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: March 16, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.