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Protein

Biopolymer transport protein ExbD

Gene

exbD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.

GO - Molecular functioni

  • energy transducer activity Source: EcoCyc
  • identical protein binding Source: IntAct
  • transporter activity Source: InterPro

GO - Biological processi

  • bacteriocin transport Source: UniProtKB-KW
  • protein stabilization Source: EcoCyc
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processBacteriocin transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG10272-MONOMER.
MetaCyc:EG10272-MONOMER.

Protein family/group databases

TCDBi1.A.30.2.1. the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Biopolymer transport protein ExbD
Gene namesi
Name:exbD
Ordered Locus Names:b3005, JW2973
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10272. exbD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22Cytoplasmic1 PublicationAdd BLAST22
Transmembranei23 – 43Helical; Signal-anchor for type II membrane proteinCuratedAdd BLAST21
Topological domaini44 – 141Periplasmic1 PublicationAdd BLAST98

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
  • plasma membrane protein complex Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001291171 – 141Biopolymer transport protein ExbDAdd BLAST141

Proteomic databases

PaxDbiP0ABV2.
PRIDEiP0ABV2.

Expressioni

Inductioni

Induced 2.1-fold by hydroxyurea.1 Publication

Interactioni

Subunit structurei

The accessory proteins ExbB and ExbD seem to form a complex with TonB.

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4261413. 243 interactors.
DIPiDIP-47973N.
IntActiP0ABV2. 4 interactors.
STRINGi316385.ECDH10B_3181.

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 41Combined sources18
Beta strandi65 – 69Combined sources5
Turni70 – 72Combined sources3
Beta strandi73 – 76Combined sources4
Beta strandi79 – 81Combined sources3
Helixi86 – 93Combined sources8
Beta strandi94 – 96Combined sources3
Beta strandi102 – 106Combined sources5
Helixi112 – 124Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PFUNMR-A44-141[»]
5SV1X-ray3.50Y/Z1-49[»]
ProteinModelPortaliP0ABV2.
SMRiP0ABV2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABV2.

Family & Domainsi

Sequence similaritiesi

Belongs to the ExbD/TolR family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZZF. Bacteria.
COG0848. LUCA.
HOGENOMiHOG000134906.
InParanoidiP0ABV2.
KOiK03559.
PhylomeDBiP0ABV2.

Family and domain databases

InterProiView protein in InterPro
IPR003400. ExbD.
IPR014170. TonB_ExbD_1.
PfamiView protein in Pfam
PF02472. ExbD. 1 hit.
TIGRFAMsiTIGR02803. ExbD_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMHLNENLD DNGEMHDINV TPFIDVMLVL LIIFMVAAPL ATVDVKVNLP
60 70 80 90 100
ASTSTPQPRP EKPVYLSVKA DNSMFIGNDP VTDETMITAL NALTEGKKDT
110 120 130 140
TIFFRADKTV DYETLMKVMD TLHQAGYLKI GLVGEETAKA K
Length:141
Mass (Da):15,527
Last modified:October 25, 2005 - v1
Checksum:i25A539A2FAEB9F6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28819 Genomic DNA. Translation: AAA23733.1.
U28377 Genomic DNA. Translation: AAA69172.1.
U00096 Genomic DNA. Translation: AAC76041.1.
AP009048 Genomic DNA. Translation: BAE77063.1.
PIRiJV0030. BVECED.
RefSeqiNP_417478.1. NC_000913.3.
WP_001240712.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76041; AAC76041; b3005.
BAE77063; BAE77063; BAE77063.
GeneIDi946345.
KEGGiecj:JW2973.
eco:b3005.
PATRICifig|1411691.4.peg.3724.

Similar proteinsi

Entry informationi

Entry nameiEXBD_ECOLI
AccessioniPrimary (citable) accession number: P0ABV2
Secondary accession number(s): P18784, Q2M9J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families