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Protein

Biopolymer transport protein ExbD

Gene

exbD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.

GO - Molecular functioni

  • energy transducer activity Source: EcoCyc
  • identical protein binding Source: IntAct
  • transporter activity Source: InterPro

GO - Biological processi

  • bacteriocin transport Source: UniProtKB-KW
  • protein stabilization Source: EcoCyc
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Bacteriocin transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG10272-MONOMER.
ECOL316407:JW2973-MONOMER.
MetaCyc:EG10272-MONOMER.

Protein family/group databases

TCDBi1.A.30.2.1. the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Biopolymer transport protein ExbD
Gene namesi
Name:exbD
Ordered Locus Names:b3005, JW2973
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10272. exbD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Cytoplasmic1 PublicationAdd
BLAST
Transmembranei23 – 4321Helical; Signal-anchor for type II membrane proteinCuratedAdd
BLAST
Topological domaini44 – 14198Periplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Biopolymer transport protein ExbDPRO_0000129117Add
BLAST

Proteomic databases

EPDiP0ABV2.
PaxDbiP0ABV2.

Expressioni

Inductioni

Induced 2.1-fold by hydroxyurea.1 Publication

Interactioni

Subunit structurei

The accessory proteins ExbB and ExbD seem to form a complex with TonB.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-6417016,EBI-6417016
exbBP0ABU72EBI-6417016,EBI-6399986
tonBP029293EBI-6417016,EBI-6399993

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4261413. 243 interactions.
DIPiDIP-47973N.
IntActiP0ABV2. 4 interactions.
STRINGi511145.b3005.

Structurei

Secondary structure

1
141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi65 – 695Combined sources
Turni70 – 723Combined sources
Beta strandi73 – 764Combined sources
Beta strandi79 – 813Combined sources
Helixi86 – 938Combined sources
Beta strandi94 – 963Combined sources
Beta strandi102 – 1065Combined sources
Helixi112 – 12413Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PFUNMR-A44-141[»]
ProteinModelPortaliP0ABV2.
SMRiP0ABV2. Positions 43-141.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0ABV2.

Family & Domainsi

Sequence similaritiesi

Belongs to the ExbD/TolR family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZZF. Bacteria.
COG0848. LUCA.
HOGENOMiHOG000134906.
InParanoidiP0ABV2.
KOiK03559.
OMAiGIEKIGM.
PhylomeDBiP0ABV2.

Family and domain databases

InterProiIPR003400. ExbD.
IPR014170. TonB_ExbD_1.
[Graphical view]
PfamiPF02472. ExbD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02803. ExbD_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMHLNENLD DNGEMHDINV TPFIDVMLVL LIIFMVAAPL ATVDVKVNLP
60 70 80 90 100
ASTSTPQPRP EKPVYLSVKA DNSMFIGNDP VTDETMITAL NALTEGKKDT
110 120 130 140
TIFFRADKTV DYETLMKVMD TLHQAGYLKI GLVGEETAKA K
Length:141
Mass (Da):15,527
Last modified:October 25, 2005 - v1
Checksum:i25A539A2FAEB9F6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28819 Genomic DNA. Translation: AAA23733.1.
U28377 Genomic DNA. Translation: AAA69172.1.
U00096 Genomic DNA. Translation: AAC76041.1.
AP009048 Genomic DNA. Translation: BAE77063.1.
PIRiJV0030. BVECED.
RefSeqiNP_417478.1. NC_000913.3.
WP_001240712.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76041; AAC76041; b3005.
BAE77063; BAE77063; BAE77063.
GeneIDi946345.
KEGGiecj:JW2973.
eco:b3005.
PATRICi32121426. VBIEscCol129921_3100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28819 Genomic DNA. Translation: AAA23733.1.
U28377 Genomic DNA. Translation: AAA69172.1.
U00096 Genomic DNA. Translation: AAC76041.1.
AP009048 Genomic DNA. Translation: BAE77063.1.
PIRiJV0030. BVECED.
RefSeqiNP_417478.1. NC_000913.3.
WP_001240712.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PFUNMR-A44-141[»]
ProteinModelPortaliP0ABV2.
SMRiP0ABV2. Positions 43-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261413. 243 interactions.
DIPiDIP-47973N.
IntActiP0ABV2. 4 interactions.
STRINGi511145.b3005.

Protein family/group databases

TCDBi1.A.30.2.1. the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily.

Proteomic databases

EPDiP0ABV2.
PaxDbiP0ABV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76041; AAC76041; b3005.
BAE77063; BAE77063; BAE77063.
GeneIDi946345.
KEGGiecj:JW2973.
eco:b3005.
PATRICi32121426. VBIEscCol129921_3100.

Organism-specific databases

EchoBASEiEB0268.
EcoGeneiEG10272. exbD.

Phylogenomic databases

eggNOGiENOG4108ZZF. Bacteria.
COG0848. LUCA.
HOGENOMiHOG000134906.
InParanoidiP0ABV2.
KOiK03559.
OMAiGIEKIGM.
PhylomeDBiP0ABV2.

Enzyme and pathway databases

BioCyciEcoCyc:EG10272-MONOMER.
ECOL316407:JW2973-MONOMER.
MetaCyc:EG10272-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0ABV2.
PROiP0ABV2.

Family and domain databases

InterProiIPR003400. ExbD.
IPR014170. TonB_ExbD_1.
[Graphical view]
PfamiPF02472. ExbD. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02803. ExbD_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEXBD_ECOLI
AccessioniPrimary (citable) accession number: P0ABV2
Secondary accession number(s): P18784, Q2M9J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.