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Protein

Tol-Pal system protein TolQ

Gene

tolQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity (PubMed:1683466, PubMed:17233825). Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction (PubMed:11722743). Is also involved in the uptake of group A colicins (colicins A, E1, E2, E3, and K) and in the uptake of filamentous phage DNA (PubMed:1683466, PubMed:3294803). The Tol-Pal system is also required for polar localization of chemoreceptors clusters (PubMed:24720726).1 Publication5 Publications

GO - Biological processi

  • bacteriocin transport Source: EcoCyc
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • protein import Source: EcoliWiki

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciEcoCyc:EG11010-MONOMER

Protein family/group databases

TCDBi1.A.30.2.2 the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Tol-Pal system protein TolQUniRule annotationCurated
Gene namesi
Name:tolQ1 PublicationUniRule annotation
Synonyms:fii1 Publication
Ordered Locus Names:b0737, JW0727
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11010 tolQ

Subcellular locationi

  • Cell inner membrane UniRule annotation2 Publications; Multi-pass membrane protein UniRule annotation1 Publication1 Publication
  • Note: Accumulates at cell constriction sites. Recruitment to the division site is dependent on FtsN activity.1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15Periplasmic1 Publication1 PublicationAdd BLAST15
Transmembranei16 – 36HelicalUniRule annotationAdd BLAST21
Topological domaini37 – 138Cytoplasmic1 Publication1 PublicationAdd BLAST102
Transmembranei139 – 159HelicalUniRule annotationAdd BLAST21
Topological domaini160 – 170Periplasmic1 Publication1 PublicationAdd BLAST11
Transmembranei171 – 191HelicalUniRule annotationAdd BLAST21
Topological domaini192 – 230Cytoplasmic1 Publication2 PublicationsAdd BLAST39

GO - Cellular componenti

  • cell division site Source: EcoCyc
  • cell envelope Source: EcoCyc
  • integral component of membrane Source: EcoliWiki
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutants lacking the tol-pal cluster suffer delayed outer membrane invagination and contain large outer membrane blebs at constriction sites and cell poles.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi177A → V: Significantly reduces TolA-Pal interaction. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458221 – 230Tol-Pal system protein TolQAdd BLAST230

Proteomic databases

PaxDbiP0ABU9
PRIDEiP0ABU9

Interactioni

Subunit structurei

The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer (PubMed:17233825). TolQ interacts with the N-terminal domain of TolA and with TolR (PubMed:7744737, PubMed:10419942).1 Publication2 Publications

Protein-protein interaction databases

BioGridi4259453, 275 interactors
DIPiDIP-11008N
STRINGi316385.ECDH10B_0804

Structurei

3D structure databases

ProteinModelPortaliP0ABU9
SMRiP0ABU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ExbB/TolQ family.UniRule annotationCurated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105E02 Bacteria
COG0811 LUCA
HOGENOMiHOG000134795
InParanoidiP0ABU9
KOiK03562
OMAiSWTYIFR
PhylomeDBiP0ABU9

Family and domain databases

HAMAPiMF_02202 TolQ, 1 hit
InterProiView protein in InterPro
IPR002898 MotA_ExbB_proton_chnl
IPR014163 Tol-Pal_TolQ
PfamiView protein in Pfam
PF01618 MotA_ExbB, 1 hit
TIGRFAMsiTIGR02796 tolQ, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDMNILDLF LKASLLVKLI MLILIGFSIA SWAIIIQRTR ILNAAAREAE
60 70 80 90 100
AFEDKFWSGI ELSRLYQESQ GKRDNLTGSE QIFYSGFKEF VRLHRANSHA
110 120 130 140 150
PEAVVEGASR AMRISMNREL ENLETHIPFL GTVGSISPYI GLFGTVWGIM
160 170 180 190 200
HAFIALGAVK QATLQMVAPG IAEALIATAI GLFAAIPAVM AYNRLNQRVN
210 220 230
KLELNYDNFM EEFTAILHRQ AFTVSESNKG
Length:230
Mass (Da):25,598
Last modified:October 25, 2005 - v1
Checksum:iF4356F6C5B0F753C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16489 Genomic DNA Translation: AAA83919.1
U00096 Genomic DNA Translation: AAC73831.1
AP009048 Genomic DNA Translation: BAA35403.1
PIRiB25980 BVECTQ
RefSeqiNP_415265.1, NC_000913.3
WP_000131314.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73831; AAC73831; b0737
BAA35403; BAA35403; BAA35403
GeneIDi948900
KEGGiecj:JW0727
eco:b0737
PATRICifig|1411691.4.peg.1535

Similar proteinsi

Entry informationi

Entry nameiTOLQ_ECOLI
AccessioniPrimary (citable) accession number: P0ABU9
Secondary accession number(s): P05828
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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