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Protein

Biopolymer transport protein ExbB

Gene

exbB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB.

GO - Molecular functioni

  • energy transducer activity Source: EcoCyc
  • identical protein binding Source: EcoCyc
  • protein transporter activity Source: InterPro
  • substrate-specific transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • bacteriocin transport Source: UniProtKB-KW
  • protein stabilization Source: EcoCyc

Keywordsi

Biological processBacteriocin transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG10271-MONOMER.
MetaCyc:EG10271-MONOMER.

Protein family/group databases

TCDBi1.A.30.2.1. the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Biopolymer transport protein ExbB
Gene namesi
Name:exbB
Ordered Locus Names:b3006, JW2974
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10271. exbB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15PeriplasmicCuratedAdd BLAST15
Transmembranei16 – 39HelicalCuratedAdd BLAST24
Topological domaini40 – 127CytoplasmicCuratedAdd BLAST88
Transmembranei128 – 155HelicalCuratedAdd BLAST28
Topological domaini156 – 161PeriplasmicCurated6
Transmembranei162 – 194HelicalCuratedAdd BLAST33
Topological domaini195 – 244CytoplasmicCuratedAdd BLAST50

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
  • plasma membrane protein complex Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001457991 – 244Biopolymer transport protein ExbBAdd BLAST244

Proteomic databases

PaxDbiP0ABU7.
PRIDEiP0ABU7.

Expressioni

Inductioni

Induced 2.4-fold by hydroxyurea.1 Publication

Interactioni

Subunit structurei

The accessory proteins ExbB and ExbD seem to form a complex with TonB.

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4261412. 969 interactors.
DIPiDIP-47841N.
IntActiP0ABU7. 29 interactors.
STRINGi316385.ECDH10B_3182.

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 16Combined sources5
Helixi21 – 62Combined sources42
Helixi68 – 75Combined sources8
Turni79 – 81Combined sources3
Helixi83 – 97Combined sources15
Turni98 – 100Combined sources3
Helixi104 – 107Combined sources4
Helixi110 – 126Combined sources17
Turni127 – 129Combined sources3
Helixi130 – 159Combined sources30
Turni160 – 163Combined sources4
Helixi167 – 169Combined sources3
Helixi171 – 232Combined sources62

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5SV0X-ray2.60A/B/C/D/E/F/G/H/I/J1-244[»]
5SV1X-ray3.50A/B/C/D/E/F/G/H/I/J1-244[»]
ProteinModelPortaliP0ABU7.
SMRiP0ABU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ExbB/TolQ family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CWK. Bacteria.
COG0811. LUCA.
HOGENOMiHOG000134793.
InParanoidiP0ABU7.
KOiK03561.
PhylomeDBiP0ABU7.

Family and domain databases

InterProiView protein in InterPro
IPR002898. MotA_ExbB_proton_chnl.
IPR014164. TonB_ExbB_1.
PfamiView protein in Pfam
PF01618. MotA_ExbB. 1 hit.
TIGRFAMsiTIGR02797. exbB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNNLMQTDL SVWGMYQHAD IVVKCVMIGL ILASVVTWAI FFSKSVEFFN
60 70 80 90 100
QKRRLKREQQ LLAEARSLNQ ANDIAADFGS KSLSLHLLNE AQNELELSEG
110 120 130 140 150
SDDNEGIKER TSFRLERRVA AVGRQMGRGN GYLATIGAIS PFVGLFGTVW
160 170 180 190 200
GIMNSFIGIA QTQTTNLAVV APGIAEALLA TAIGLVAAIP AVVIYNVFAR
210 220 230 240
QIGGFKAMLG DVAAQVLLLQ SRDLDLEASA AAHPVRVAQK LRAG
Length:244
Mass (Da):26,287
Last modified:October 25, 2005 - v1
Checksum:iCEB63893A80BA71F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51Q → L in AAA23732 (PubMed:2670903).Curated1
Sequence conflicti236R → A in AAA23732 (PubMed:2670903).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28819 Genomic DNA. Translation: AAA23732.1.
U28377 Genomic DNA. Translation: AAA69173.1.
U00096 Genomic DNA. Translation: AAC76042.1.
AP009048 Genomic DNA. Translation: BAE77064.1.
PIRiD65087. BVECXB.
RefSeqiNP_417479.1. NC_000913.3.
WP_000527844.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76042; AAC76042; b3006.
BAE77064; BAE77064; BAE77064.
GeneIDi945420.
KEGGiecj:JW2974.
eco:b3006.
PATRICifig|1411691.4.peg.3723.

Similar proteinsi

Entry informationi

Entry nameiEXBB_ECOLI
AccessioniPrimary (citable) accession number: P0ABU7
Secondary accession number(s): P18783, Q2M9J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families