P0ABU7 (EXBB_ECOLI) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 52.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Biopolymer transport protein exbB | ||||
| Gene names |
| ||||
| Organism | Escherichia coli (strain K12) | ||||
| Taxonomic identifier | 83333 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 244 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in the tonB-dependent energy-dependent transport of various receptor-bound substrates. Protects exbD from proteolytic degradation and functionally stabilizes tonB. |
| Subunit structure | The accessory proteins exbB and exbD seem to form a complex with tonB. |
| Subcellular location | |
| Sequence similarities | Belongs to the exbB/tolQ family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Bacteriocin transport Protein transport Transport |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | bacteriocin transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein transporter activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 244 | 244 | Biopolymer transport protein exbB | PRO_0000145799 | |||||
Regions | |||||||||
| Topological domain | 1 – 15 | 15 | Periplasmic Probable | ||||||
| Transmembrane | 16 – 39 | 24 | Helical; Probable | ||||||
| Topological domain | 40 – 127 | 88 | Cytoplasmic Probable | ||||||
| Transmembrane | 128 – 155 | 28 | Helical; Probable | ||||||
| Topological domain | 156 – 161 | 6 | Periplasmic Probable | ||||||
| Transmembrane | 162 – 194 | 33 | Helical; Probable | ||||||
| Topological domain | 195 – 244 | 50 | Cytoplasmic Probable | ||||||
Experimental info | |||||||||
| Sequence conflict | 51 | 1 | Q → L in AAA23732. Ref.1 | ||||||
| Sequence conflict | 236 | 1 | R → A in AAA23732. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Import of biopolymers into Escherichia coli: nucleotide sequences of the exbB and exbD genes are homologous to those of the tolQ and tolR genes, respectively." Eick-Helmerich K., Braun V. J. Bacteriol. 171:5117-5126(1989) [PubMed: 2670903] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12. |
| [2] | "The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076. |
| [3] | "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911. |
| [4] | "Topology of the ExbB protein in the cytoplasmic membrane of Escherichia coli." Kampfenkel K., Braun V. J. Biol. Chem. 268:6050-6057(1993) [PubMed: 8449962] [Abstract] Cited for: TOPOLOGY. |
| [5] | "Global topology analysis of the Escherichia coli inner membrane proteome." Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G. Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: K12 / MG1655 / ATCC 47076. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M28819 Genomic DNA. Translation: AAA23732.1. U28377 Genomic DNA. Translation: AAA69173.1. U00096 Genomic DNA. Translation: AAC76042.1. AP009048 Genomic DNA. Translation: BAE77064.1. |
| PIR | BVECXB. D65087. |
| RefSeq | NP_417479.1. NC_000913.2. |
3D structure databases | |
| ProteinModelPortal | P0ABU7. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-47841N. |
Protein family/group databases | |
| TCDB | 1.A.30.2.1. H+- or Na+-translocating bacterial flagellar motor/ExbBD outer membrane transport energizer (Mot/Exb) superfamily. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBESCT00000003846; EBESCP00000003846; EBESCG00000003142. EBESCT00000018349; EBESCP00000017640; EBESCG00000017403. |
| GeneID | 945420. |
| GenomeReviews | Gene locus JW2974 in contig AP009048_GR. Gene locus b3006 in contig U00096_GR. |
| KEGG | ecj:JW2974. eco:b3006. |
| PATRIC | 32121428. VBIEscCol129921_3101. |
Organism-specific databases | |
| EchoBASE | EB0267. |
| EcoGene | EG10271. exbB. |
Phylogenomic databases | |
| eggNOG | COG0811. |
| GeneTree | EBGT00050000010126. |
| HOGENOM | HBG681852. |
| OMA | DDNNGIK. |
| PhylomeDB | P0ABU7. |
| ProtClustDB | PRK10414. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:EG10271-MONOMER. |
Gene expression databases | |
| Genevestigator | P0ABU7. |
Family and domain databases | |
| InterPro | IPR002898. MotA_ExbB_proton_chnl. IPR014164. TonB_ExbB_1. [Graphical view] |
| KO | K03561. |
| Pfam | PF01618. MotA_ExbB. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR02797. ExbB. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | EXBB_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P0ABU7 Secondary accession number(s): P18783, Q2M9J2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| SIMILARITY comments Index of protein domains and families |

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