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Protein

Biopolymer transport protein ExbB

Gene

exbB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB.

GO - Molecular functioni

  • energy transducer activity Source: EcoCyc
  • protein transporter activity Source: InterPro

GO - Biological processi

  • bacteriocin transport Source: UniProtKB-KW
  • protein stabilization Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Bacteriocin transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG10271-MONOMER.
ECOL316407:JW2974-MONOMER.
MetaCyc:EG10271-MONOMER.

Protein family/group databases

TCDBi1.A.30.2.1. the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Biopolymer transport protein ExbB
Gene namesi
Name:exbB
Ordered Locus Names:b3006, JW2974
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10271. exbB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515PeriplasmicCuratedAdd
BLAST
Transmembranei16 – 3924HelicalCuratedAdd
BLAST
Topological domaini40 – 12788CytoplasmicCuratedAdd
BLAST
Transmembranei128 – 15528HelicalCuratedAdd
BLAST
Topological domaini156 – 1616PeriplasmicCurated
Transmembranei162 – 19433HelicalCuratedAdd
BLAST
Topological domaini195 – 24450CytoplasmicCuratedAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Biopolymer transport protein ExbBPRO_0000145799Add
BLAST

Proteomic databases

EPDiP0ABU7.
PaxDbiP0ABU7.
PRIDEiP0ABU7.

Expressioni

Inductioni

Induced 2.4-fold by hydroxyurea.1 Publication

Interactioni

Subunit structurei

The accessory proteins ExbB and ExbD seem to form a complex with TonB.

Binary interactionsi

WithEntry#Exp.IntActNotes
exbDP0ABV22EBI-6399986,EBI-6417016
tonBP029292EBI-6399986,EBI-6399993

Protein-protein interaction databases

BioGridi4261412. 969 interactions.
DIPiDIP-47841N.
IntActiP0ABU7. 3 interactions.
STRINGi511145.b3006.

Structurei

3D structure databases

ProteinModelPortaliP0ABU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ExbB/TolQ family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CWK. Bacteria.
COG0811. LUCA.
HOGENOMiHOG000134793.
InParanoidiP0ABU7.
KOiK03561.
OMAiMAHDLSP.
PhylomeDBiP0ABU7.

Family and domain databases

InterProiIPR002898. MotA_ExbB_proton_chnl.
IPR014164. TonB_ExbB_1.
[Graphical view]
PfamiPF01618. MotA_ExbB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02797. exbB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0ABU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNNLMQTDL SVWGMYQHAD IVVKCVMIGL ILASVVTWAI FFSKSVEFFN
60 70 80 90 100
QKRRLKREQQ LLAEARSLNQ ANDIAADFGS KSLSLHLLNE AQNELELSEG
110 120 130 140 150
SDDNEGIKER TSFRLERRVA AVGRQMGRGN GYLATIGAIS PFVGLFGTVW
160 170 180 190 200
GIMNSFIGIA QTQTTNLAVV APGIAEALLA TAIGLVAAIP AVVIYNVFAR
210 220 230 240
QIGGFKAMLG DVAAQVLLLQ SRDLDLEASA AAHPVRVAQK LRAG
Length:244
Mass (Da):26,287
Last modified:October 25, 2005 - v1
Checksum:iCEB63893A80BA71F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511Q → L in AAA23732 (PubMed:2670903).Curated
Sequence conflicti236 – 2361R → A in AAA23732 (PubMed:2670903).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28819 Genomic DNA. Translation: AAA23732.1.
U28377 Genomic DNA. Translation: AAA69173.1.
U00096 Genomic DNA. Translation: AAC76042.1.
AP009048 Genomic DNA. Translation: BAE77064.1.
PIRiD65087. BVECXB.
RefSeqiNP_417479.1. NC_000913.3.
WP_000527844.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76042; AAC76042; b3006.
BAE77064; BAE77064; BAE77064.
GeneIDi945420.
KEGGiecj:JW2974.
eco:b3006.
PATRICi32121428. VBIEscCol129921_3101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28819 Genomic DNA. Translation: AAA23732.1.
U28377 Genomic DNA. Translation: AAA69173.1.
U00096 Genomic DNA. Translation: AAC76042.1.
AP009048 Genomic DNA. Translation: BAE77064.1.
PIRiD65087. BVECXB.
RefSeqiNP_417479.1. NC_000913.3.
WP_000527844.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261412. 969 interactions.
DIPiDIP-47841N.
IntActiP0ABU7. 3 interactions.
STRINGi511145.b3006.

Protein family/group databases

TCDBi1.A.30.2.1. the h(+)- or na(+)-translocating bacterial flagellar motor/exbbd outer membrane transport energizer (mot/exb) superfamily.

Proteomic databases

EPDiP0ABU7.
PaxDbiP0ABU7.
PRIDEiP0ABU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76042; AAC76042; b3006.
BAE77064; BAE77064; BAE77064.
GeneIDi945420.
KEGGiecj:JW2974.
eco:b3006.
PATRICi32121428. VBIEscCol129921_3101.

Organism-specific databases

EchoBASEiEB0267.
EcoGeneiEG10271. exbB.

Phylogenomic databases

eggNOGiENOG4105CWK. Bacteria.
COG0811. LUCA.
HOGENOMiHOG000134793.
InParanoidiP0ABU7.
KOiK03561.
OMAiMAHDLSP.
PhylomeDBiP0ABU7.

Enzyme and pathway databases

BioCyciEcoCyc:EG10271-MONOMER.
ECOL316407:JW2974-MONOMER.
MetaCyc:EG10271-MONOMER.

Miscellaneous databases

PROiP0ABU7.

Family and domain databases

InterProiIPR002898. MotA_ExbB_proton_chnl.
IPR014164. TonB_ExbB_1.
[Graphical view]
PfamiPF01618. MotA_ExbB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02797. exbB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEXBB_ECOLI
AccessioniPrimary (citable) accession number: P0ABU7
Secondary accession number(s): P18783, Q2M9J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.