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Protein

Probable cystine transporter YijE

Gene

yijE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in response to cystine. Overexpression confers tolerance to excess cystine.1 Publication

GO - Molecular functioni

  • sulfur amino acid transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • amino acid transmembrane transport Source: GOC
  • sulfur amino acid transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG11902-MONOMER.
ECOL316407:JW5557-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cystine transporter YijECurated
Gene namesi
Name:yijE
Ordered Locus Names:b3943, JW5557
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11902. yijE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 88CytoplasmicCurated
Transmembranei9 – 2921HelicalSequence analysisAdd
BLAST
Topological domaini30 – 389PeriplasmicCurated
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Topological domaini60 – 7112CytoplasmicCuratedAdd
BLAST
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Topological domaini93 – 986PeriplasmicCurated
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Topological domaini120 – 1278CytoplasmicCurated
Transmembranei128 – 14821HelicalSequence analysisAdd
BLAST
Topological domaini149 – 1502PeriplasmicCurated
Transmembranei151 – 17121HelicalSequence analysisAdd
BLAST
Topological domaini172 – 18514CytoplasmicCuratedAdd
BLAST
Transmembranei186 – 20621HelicalSequence analysisAdd
BLAST
Topological domaini207 – 21812PeriplasmicCuratedAdd
BLAST
Transmembranei219 – 23921HelicalSequence analysisAdd
BLAST
Topological domaini240 – 2456CytoplasmicCurated
Transmembranei246 – 26621HelicalSequence analysisAdd
BLAST
Topological domaini267 – 2682PeriplasmicCurated
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST
Topological domaini290 – 30112Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deletion increases the sensitivity to cystine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Probable cystine transporter YijEPRO_0000108175Add
BLAST

Proteomic databases

PaxDbiP0ABT8.

Expressioni

Inductioni

Up-regulated by cystine.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261103. 85 interactions.
STRINGi511145.b3943.

Structurei

3D structure databases

ProteinModelPortaliP0ABT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 141129EamA 1Sequence analysisAdd
BLAST
Domaini152 – 289138EamA 2Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the EamA transporter family.Curated
Contains 2 EamA domains.Sequence analysis

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108Q5Y. Bacteria.
ENOG410Y0KE. LUCA.
HOGENOMiHOG000277404.
InParanoidiP0ABT8.
OMAiWIVMLIR.
OrthoDBiEOG651SW4.
PhylomeDBiP0ABT8.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0ABT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAGKSNPL AISGLVVLTL IWSYSWIFMK QVTSYIGAFD FTALRCIFGA
60 70 80 90 100
LVLFIVLLLR GRGMRPTPFK YTLAIALLQT CGMVGLAQWA LVSGGAGKVA
110 120 130 140 150
ILSYTMPFWV VIFAALFLGE RLRRGQYFAI LIAAFGLFLV LQPWQLDFSS
160 170 180 190 200
MKSAMLAILS GVSWGASAIV AKRLYARHPR VDLLSLTSWQ MLYAALVMSV
210 220 230 240 250
VALLVPQREI DWQPTVFWAL AYSAILATAL AWSLWLFVLK NLPASIASLS
260 270 280 290 300
TLAVPVCGVL FSWWLLGENP GAVEGSGIVL IVLALALVSR KKKEAVSVKR

I
Length:301
Mass (Da):32,866
Last modified:October 25, 2005 - v1
Checksum:i1A822058FDA28696
GO

Sequence cautioni

The sequence AAC43049.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43049.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76925.2.
AP009048 Genomic DNA. Translation: BAE77367.1.
PIRiI78664.
RefSeqiNP_418378.4. NC_000913.3.
WP_001271242.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76925; AAC76925; b3943.
BAE77367; BAE77367; BAE77367.
GeneIDi948445.
KEGGiecj:JW5557.
eco:b3943.
PATRICi32123407. VBIEscCol129921_4064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA. Translation: AAC43049.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76925.2.
AP009048 Genomic DNA. Translation: BAE77367.1.
PIRiI78664.
RefSeqiNP_418378.4. NC_000913.3.
WP_001271242.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0ABT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261103. 85 interactions.
STRINGi511145.b3943.

Proteomic databases

PaxDbiP0ABT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76925; AAC76925; b3943.
BAE77367; BAE77367; BAE77367.
GeneIDi948445.
KEGGiecj:JW5557.
eco:b3943.
PATRICi32123407. VBIEscCol129921_4064.

Organism-specific databases

EchoBASEiEB1847.
EcoGeneiEG11902. yijE.

Phylogenomic databases

eggNOGiENOG4108Q5Y. Bacteria.
ENOG410Y0KE. LUCA.
HOGENOMiHOG000277404.
InParanoidiP0ABT8.
OMAiWIVMLIR.
OrthoDBiEOG651SW4.
PhylomeDBiP0ABT8.

Enzyme and pathway databases

BioCyciEcoCyc:EG11902-MONOMER.
ECOL316407:JW5557-MONOMER.

Miscellaneous databases

PROiP0ABT8.

Family and domain databases

InterProiIPR000620. EamA_dom.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes."
    Blattner F.R., Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.
    Nucleic Acids Res. 21:5408-5417(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Induction of the Escherichia coli yijE gene expression by cystine."
    Yamamoto K., Nonaka G., Ozawa T., Takumi K., Ishihama A.
    Biosci. Biotechnol. Biochem. 79:218-222(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: K12 / BW25113.

Entry informationi

Entry nameiYIJE_ECOLI
AccessioniPrimary (citable) accession number: P0ABT8
Secondary accession number(s): P32667, Q2M8N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: January 20, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.