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Protein

Probable cystine transporter YijE

Gene

yijE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in response to cystine. Overexpression confers tolerance to excess cystine.1 Publication

GO - Molecular functioni

  • sulfur amino acid transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • sulfur amino acid transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EG11902-MONOMER
MetaCyc:EG11902-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cystine transporter YijECurated
Gene namesi
Name:yijE
Ordered Locus Names:b3943, JW5557
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11902 yijE

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicCurated8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 38PeriplasmicCurated9
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 71CytoplasmicCuratedAdd BLAST12
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Topological domaini93 – 98PeriplasmicCurated6
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 127CytoplasmicCurated8
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 150PeriplasmicCurated2
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 185CytoplasmicCuratedAdd BLAST14
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Topological domaini207 – 218PeriplasmicCuratedAdd BLAST12
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 245CytoplasmicCurated6
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 268PeriplasmicCurated2
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 301Cytoplasmic1 PublicationAdd BLAST12

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deletion increases the sensitivity to cystine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001081751 – 301Probable cystine transporter YijEAdd BLAST301

Proteomic databases

PaxDbiP0ABT8
PRIDEiP0ABT8

Expressioni

Inductioni

Up-regulated by cystine.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261103, 89 interactors
STRINGi316385.ECDH10B_4132

Structurei

3D structure databases

ProteinModelPortaliP0ABT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 141EamA 1Sequence analysisAdd BLAST129
Domaini152 – 289EamA 2Sequence analysisAdd BLAST138

Sequence similaritiesi

Belongs to the EamA transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108Q5Y Bacteria
ENOG410Y0KE LUCA
HOGENOMiHOG000277404
InParanoidiP0ABT8
OMAiGLNWPVM
PhylomeDBiP0ABT8

Family and domain databases

InterProiView protein in InterPro
IPR000620 EamA_dom
PfamiView protein in Pfam
PF00892 EamA, 2 hits

Sequencei

Sequence statusi: Complete.

P0ABT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAGKSNPL AISGLVVLTL IWSYSWIFMK QVTSYIGAFD FTALRCIFGA
60 70 80 90 100
LVLFIVLLLR GRGMRPTPFK YTLAIALLQT CGMVGLAQWA LVSGGAGKVA
110 120 130 140 150
ILSYTMPFWV VIFAALFLGE RLRRGQYFAI LIAAFGLFLV LQPWQLDFSS
160 170 180 190 200
MKSAMLAILS GVSWGASAIV AKRLYARHPR VDLLSLTSWQ MLYAALVMSV
210 220 230 240 250
VALLVPQREI DWQPTVFWAL AYSAILATAL AWSLWLFVLK NLPASIASLS
260 270 280 290 300
TLAVPVCGVL FSWWLLGENP GAVEGSGIVL IVLALALVSR KKKEAVSVKR

I
Length:301
Mass (Da):32,866
Last modified:October 25, 2005 - v1
Checksum:i1A822058FDA28696
GO

Sequence cautioni

The sequence AAC43049 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00006 Genomic DNA Translation: AAC43049.1 Different initiation.
U00096 Genomic DNA Translation: AAC76925.2
AP009048 Genomic DNA Translation: BAE77367.1
PIRiI78664
RefSeqiNP_418378.4, NC_000913.3
WP_001271242.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76925; AAC76925; b3943
BAE77367; BAE77367; BAE77367
GeneIDi948445
KEGGiecj:JW5557
eco:b3943
PATRICifig|1411691.4.peg.2761

Similar proteinsi

Entry informationi

Entry nameiYIJE_ECOLI
AccessioniPrimary (citable) accession number: P0ABT8
Secondary accession number(s): P32667, Q2M8N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health