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Protein

DNA polymerase III subunit theta

Gene

holE

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).By similarity
The exact function of the theta subunit is unknown.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase III subunit theta (EC:2.7.7.7)
Gene namesi
Name:holE
Ordered Locus Names:Z2891, ECs2552
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001055231 – 76DNA polymerase III subunit thetaAdd BLAST76

Interactioni

Subunit structurei

The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau. The composition of the holoenzyme is, therefore: (alpha,epsilon,theta)[2]-(gamma/tau)[3]-delta,delta', psi,chi-beta[4] (By similarity).By similarity

Protein-protein interaction databases

STRINGi155864.Z2891

Structurei

3D structure databases

ProteinModelPortaliP0ABT0
SMRiP0ABT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105MPK Bacteria
ENOG4111UZC LUCA
HOGENOMiHOG000219272
KOiK02345
OMAiFRERYNM

Family and domain databases

Gene3Di1.20.58.250, 1 hit
InterProiView protein in InterPro
IPR009052 DNA_pol_III_theta_bac
IPR036745 PolIII_theta_sf
PfamiView protein in Pfam
PF06440 DNA_pol3_theta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD057609 DNA_pol_III_theta_bac, 1 hit

Sequencei

Sequence statusi: Complete.

P0ABT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKNLAKLDQ TEMDKVNVDL AAAGVAFKER YNMPVIAEAV EREQPEHLRS
60 70
WFRERLIAHR LASVNLSRLP YEPKLK
Length:76
Mass (Da):8,846
Last modified:October 25, 2005 - v1
Checksum:i3667D87327E96556
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA Translation: AAG56832.1
BA000007 Genomic DNA Translation: BAB35975.1
PIRiD85796
H90947
RefSeqiNP_310579.1, NC_002695.1
WP_000916763.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG56832; AAG56832; Z2891
BAB35975; BAB35975; BAB35975
GeneIDi913059
KEGGiece:Z2891
ecs:ECs2552
PATRICifig|386585.9.peg.2675

Similar proteinsi

Entry informationi

Entry nameiHOLE_ECO57
AccessioniPrimary (citable) accession number: P0ABT0
Secondary accession number(s): P28689
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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